基于互信息量和模糊梯度相似性的医学图像配准

本文分析了基于互信息量的医学图像配准算法中存在的鲁棒性问题,提出创建图像的模糊梯度场及建立模糊梯度相似性测度,并将其结合到互信息量配准算法当中.实验证明,本方法很好的解决了传统基于互信息量的方法中存在的鲁棒性问题,能够快速稳定地实现医学图像配准.     

A protocol for evaluation of similarity measures for rigid registration

The accuracy and robustness of a registration method depend on a number of factors, such as imaging modality, image content and image degrading effects, the class of spatial transformation used for registration, similarity measure, optimization, and numerous implementation details. The complex interdependence of these factors makes the assessment of the influence of a particular factor on registration difficult, although it is often desirable to have some estimate of such influences prior to registration. The similarity measure used to create the cost function is one of the factors that most influences the quality of registration. Traditionally, limited information on the behavior of a similarity measure is obtained either by studying the quality of the final registration or by drawing plots of similarity measure values obtained by translating or rotating one image relative to the "gold standard." In this paper, we present a protocol for a more thorough, optimization-independent, and systematic statistical evaluation of similarity measures. This protocol estimates a similarity measure's capture range, the number, location and extent of local optima, and the accuracy and distinctiveness of the global optimum. To show that the proposed evaluation protocol is viable, we have conducted several experiments with nine similarity measures and real computed tomography and magnetic resonance (MR) images of a spine phantom, MR brain images, and MR and positron emission tomography brain images, for which "gold standard" registrations were available. We have also studied the impact of histogram bin size on the behavior of nine similarity measures. The proposed evaluation protocol is useful for selecting the best similarity measure and corresponding optimization method for a particular application, as well as for studying the influence of sampling, interpolation, histogram bin size, partial image overlap, and image degradation, such as noise, intensity inhomogeneity, and geometrical distortions on the behavior of a similarity measure.     

红外与可见光图像配准算法

提出把二阶互信息与对齐度相结合作为相似度函数,通过Hough变换提取两幅图像中一致性较高的直线,计算它们的对齐度,最后针对不同的图像特点,调整对齐度在新相似度函数中所占比例进行配准.实验结果表明.新算法与其他几种测度函数相比有更高的精确性和鲁棒性.     

一种图像快速配准算法的研究

在基于小波分解和互信息测度的图像配准方法的基础上,提出一种改进的快速图像配准算法。首先,对图像进行小波分解,以分解后的图像的近似分量进行配准,利用互信息最大化作为相似性测度,并结合粒子群优化算法和鲍威尔算法为优化策略搜索最优配准参数。实验结果显示,此方法在得到较高的配准精度和鲁棒性的情况下,还大大减少了运算量,提高了配准的速度。     

医学图像配准中的数据抽样方法研究

针对在基于灰度的医学图像配准中,传统数据抽样方法在过抽样时产生较多的局部极值点问题,提出了基于浮动图像灰度概率分布和其梯度信息的抽样方法.通过对人体脑部的刚体配准实验,从函数曲线和收敛性能方面,对比分析了五种数据抽样方法.实验结果表明,新抽样方法可以有效地减少局部极值点,提高归一化互信息测度的收敛性能.     

基于边界距离场互信息的图像配准方法

基于图像边界平均Hausdorff距离的配准方法实现简单、速度快、有较大应用价值,但对图像边界不完全对应的情况配准效果不好。提出了一种以图像边界距离场互信息作为相似度函数的图像配准方法,以参考边界的距离场和浮动二值边界为两个离散概率分布,将其互信息作为相似度函数进行配准。实验结果表明,该算法对图像内容完全一致和内容不完全对应的图像均可得到良好的配准结果。     

对数极坐标变换域下互信息图像配准方法

当待配准中的图像中存在较大的尺度变换时,传统的图像互信息配准方法对图像尺度变换参数很敏感,易于在优化搜索时陷入局部极值点,配准效果不好。文中提出基于对数极坐标（log—polar）域的图像配准方法,它较好地分离了图像缩放参数和图像旋转参数的相互影响。仿真结果表明,该方法在大尺度图像配准场合应用时比通常的互信息方法有更高的精度和鲁棒性。     

基于归一化互信息的CT-MRI脑图像配准

医学图像配准研究有非常重要的临床应用价值。针对现在流行的基于最大互信息量的配准方法展开分析和研究。在此基础上对比研究了归一化互信息配准法。通过对一组CT-MR脑图像配准的仿真研究,证明归一化互信息配准法的配准效果很好。特别是在图像重叠区域较小的情况下,比最大互信息配准法效果优越。     

基于互信息的紫外成像仪中图像配准研究

紫外成像仪为实现放电点定位和电气设备故障诊断,需要对来自不同传感器的紫外与可见光图像进行配准。针对紫外与可见光图像成像原理差异较大,特征点提取及匹配困难的问题,文章提出一种基于互信息的紫外与可见光图像配准算法并将其应用到紫外成像仪中完成实时配准。首先计算紫外与可见光图像中的互信息,将互信息作为相似性测度,采用刚体变换模型对图像进行变换,然后通过1+1进化算法求取最优相似性测度时的空间变换参数而完成图像配准,并通过仿真和紫外成像仪样机验证了所提算法的有效性。     

基于简单Schur凹函数的图像配准测度研究

 使用互信息或归一化互信息进行图像配准时,由于噪声、模态、插值等影响,测度函数存在许多局部极值,收敛范围较窄,有可能导致误配准.该文根据一个简单的Schur凹函数,充分利用它的特殊上凸性来消除噪声等引起的小概率分布,并由Jensen-Schur测度、广义距离测度和 f 信息测度的定义,构造了六种新测度.从运算时间、收敛性能、抗噪鲁棒性方面,对这六种测度、互信息和归一化互信息进行了比较和分析.实验结果表明,Jensen-Schur-beta和D-beta测度的收敛性能优于其它测度,抗噪声能力强于其它测度,运算速度快于互信息和归一化互信息.     

基于SIFT的图像配准方法

针对大尺度图像配准和不同传感器图像配准问题,介绍了一种基于SIFT的图像配准方法。首先提取图像中适应尺度变化的不变特征点,在提取过程中加入多尺度Harris检测算子,提高了匹配点对的重复率,通过聚类和归一化互信息准则对候选匹配点对的角度、尺度和位置特征进行迭代筛选,删除错误的匹配点对,最后得到正确的匹配点对,对图像进行配准。实验结果表明：该方法能处理相似变换的图像配准。     

基于互信息和梯度的红外与可见光图像配准新方法

红外与可见光图像配准是常见的多传感器图像配准,在军事、遥感等领域有着广泛的应用。提出了一种基于互信息和图像梯度的红外与可见光图像的自动配准方法：首先,获得图像的梯度信息,然后根据定义的扩展结构获得边缘区域图像,选择最大归一化互信息作为相似性测度,使用Powell算法获得最佳配准参数。实验结果证明,本文方法较传统的基于互信息和梯度的配准方法,提高了配准的速度和精度,可以作为一种有效的粗配准的方法。     

Quantitative evaluation of image-based distortion correction in diffusion tensor imaging

A statistical method for the evaluation of image registration for a series of images based on the assessment of consistency properties of the registration results is proposed. Consistency is defined as the residual error of the composition of cyclic registrations. By combining the transformations of different algorithms the consistency error allows a quantitative comparison without the use of ground truth, specifically, it allows a determination as to whether the algorithms are compatible and hence provide comparable registrations. Consistency testing is applied to evaluate retrospective correction of eddy current-induced image distortion in diffusion tensor imaging of the brain. In the literature several image transformations and similarity measures have been proposed, generally showing a significant reduction of distortion in side-by-side comparison of parametric maps before and after registration. Transformations derived from imaging physics and a three-dimensional affine transformation as well as mutual information (MI) and local correlation (LC) similarity are compared to each other by means of consistency testing. The dedicated transformations could not demonstrate a significant difference for more than half of the series considered. LC similarity is well-suited for distortion correction providing more consistent registrations which are comparable to MI.     

采用改进梯度互信息和粒子群优化算法的红外与可见光图像配准算法

针对传统互信息图像配准容易产生局部极值,以及传统梯度互信息配准方法计算量大等问题,在互信息和梯度方法基础上构建了一种改进的梯度互信息方法,该方法直接统计梯度图像的互信息,有效地将图像梯度信息和灰度信息结合起来,不仅保证了配准精度,而且较传统梯度互信息方法减少了计算量。在参量优化的过程中,针对传统粒子群优化算法易陷入局部极值的缺点,提出了改进的粒子群优化算法,该算法在传统粒子群优化算法基础上引入混沌优化思想和遗传算法中的杂交思想,不仅能够有效抑制局部极值,而且加快了收敛速度。多种红外与可见光图像配准实验结果证明,文中提出的算法能够有效提高配准精度和速度。     

A deformable registration method for automated morphometry of MRI brain images in neuropsychiatric research

Image registration methods play a crucial role in computational neuroanatomy. This paper mainly contributes to the field of image registration with the use of nonlinear spatial transformations. Particularly, problems connected to matching magnetic resonance imaging (MRI) brain image data obtained from various subjects and with various imaging conditions are solved here. Registration is driven by local forces derived from multimodal point similarity measures which are estimated with the use of joint intensity histogram and tissue probability maps. A spatial deformation model imitating principles of continuum mechanics is used. Five similarity measures are tested in an experiment with image data obtained from the Simulated Brain Database and a quantitative evaluation of the algorithm is presented. Results of application of the method in automated spatial detection of anatomical abnormalities in first-episode schizophrenia are presented.     

A comparison of similarity measures for use in 2-D-3-D medicalimage registration

A comparison of six similarity measures for use in intensity-based two-dimensional-three-dimensional (2-D-3-D) image registration is presented. The accuracy of the similarity measures are compared to a “gold-standard” registration which has been accurately calculated using fiducial markers. The similarity measures are used to register a computed tomography (CT) scan of a spine phantom to a fluoroscopy image of the phantom. The registration is carried out within a region-of-interest in the fluoroscopy image which is user defined to contain a single vertebra. Many of the problems involved in this type of registration are caused by features which were not modeled by a phantom image alone. More realistic “gold-standard” data sets were simulated using the phantom image with clinical image features overlaid. Results show that the introduction of soft-tissue structures and interventional instruments into the phantom image can have a large effect on the performance of some similarity measures previously applied to 2-D-3-D image registration. Two measures were able to register accurately and robustly even when soft-tissue structures and interventional instruments were present as differences between the images. These measures were pattern intensity and gradient difference. Their registration accuracy, for all the rigid-body parameters except for the source to film translation, was within a root-mean-square (rms) error of 0.53 mm or degrees to the “gold-standard” values. No failures occurred while registering using these measures     

基于IPSO和综合信息的医学图像配准新方法

针对医学图像配准中采用互信息作为配准相似度函数存在配准精度不高和收敛速度慢等问题,根据图像灰度和空间结构信息,构造了一种新的基于互信息和改进型形态学梯度算子的信息配准测度函数,采用一种适用于医学图像自动配准的改进型粒子群优化(IPSO)算法,给出了一种新的基于IPSO的医学图像配准算法。实验结果表明,该配准算法稳定性好、收敛速度快,在多模态医学图像自动配准中是可行的。     

F-information measures in medical image registration

A measure for registration of medical images that currently draws much attention is mutual information. The measure originates from information theory, but has been shown to be successful for image registration as well. Information theory, however, offers many more measures that may be suitable for image registration. These all measure the divergence of the joint distribution of the images' grey values from the joint distribution that would have been found had the images been completely independent. This paper compares the performance of mutual information as a registration measure with that of other F-information measures. The measures are applied to rigid registration of positron emission tomography (PET)/magnetic resonance (MR) and MR/computed tomography (CT) images, for 35 and 41 image pairs, respectively. An accurate gold standard transformation is available for the images, based on implanted markers. The registration performance, robustness and accuracy of the measures are studied. Some of the measures are shown to perform poorly on all aspects. The majority of measures produces results similar to those of mutual information. An important finding, however, is that several measures, although slightly more difficult to optimize, can potentially yield significantly more accurate results than mutual information.     

Image Registration Using Adaptive Polar Transform

Image registration is an essential step in many image processing applications that need visual information from multiple images for comparison, integration, or analysis. Recently, researchers have introduced image registration techniques using the log-polar transform (LPT) for its rotation and scale invariant properties. However, it suffers from nonuniform sampling which makes it not suitable for applications in which the registered images are altered or occluded. Inspired by LPT, this paper presents a new registration algorithm that addresses the problems of the conventional LPT while maintaining the robustness to scale and rotation. We introduce a novel adaptive polar transform (APT) technique that evenly and effectively samples the image in the Cartesian coordinates. Combining APT with an innovative projection transform along with a matching mechanism, the proposed method yields less computational load and more accurate registration than that of the conventional LPT. Translation between the registered images is recovered with the new search scheme using Gabor feature extraction to accelerate the localization procedure. Moreover an image comparison scheme is proposed for locating the area where the image pairs differ. Experiments on real images demonstrate the effectiveness and robustness of the proposed approach for registering images that are subjected to occlusion and alteration in addition to scale, rotation, and translation.     

一种基于对称性边缘的多光谱图像配准方法

多光谱成像技术是遥感领域的一项重要技术。多光谱图像配准技术可以提高遥感图像的应用效率和能力。基于边缘结构在多光谱图像中较为稳定这一特性,提出了一种基于对称性边缘的多光谱图像配准方法,该方法主要包含“图像比例调整”、“对称性边缘提取”和“互信息配准”等三个步骤。基于天宫二号宽波段成像仪的遥感数据设计了一种多子图配准方案,验证了所提方法在可见光、短波红外和长波红外三个谱段之间图像配准的有效性。设置对比实验,将所提配准方法与其他多光谱图像配准方法进行比较,结果表明该方法在天宫二号宽波段遥感图像的配准中具有较高的精度。