稀土、苯氧乙酸、1,10-邻菲罗啉配合物的合成及抑菌

在乙醇水溶液中合成了六种苯氧乙酸(HPOA)-邻菲罗啉(Phen)-稀土三元固体配合物,采用元素分析,红外光谱,差热热重等测试方法进行表征,确定配合物的化学组成为RE(POA)3Phen(RE=La3+,Pr3+,Nd3+,Sm3+,Gd3+,Dy3+)。研究了稀土配合物的抑菌活性,结果表明稀土三元配合物的抑菌效果较单独的稀土氯化物、邻菲罗啉和苯氧乙酸好。     

邻菲啰啉-水杨酸-稀土三元配合物的合成与表征

在无水乙醇溶液中 ,以邻菲啉 ( Phen) ,水杨酸 ( HSal)为配体 ,合成了 7种稀土三元固体配合物。通过元素分析 ,红外光谱、紫外光谱、摩尔电导确定了配合物的化学组成为 RE( Phen) 2 ( Sal) 2 Cl· H2 O( RE=La3+ ,Nd3+ ,Sm3+ ,Eu3+ ,Gd3+ ,Tb3+ ,Dy3+ ) ,红外光谱表明稀土配合物中存在 RE— O和 RE— N配位键     

L-蛋氨酸多吡啶铜(Ⅱ)三元配合物的合成及与DNA的相互作用

文章合成了三种L-蛋氨酸多吡啶铜(II)三元混配配合物,[Cu(Met)(Phen)(ClO4)](ClO4)(1)(Phen=1,10-菲咯啉),[Cu(Met)(IP)(ClO4)](ClO4)(2)(IP=咪唑并[4,5-f]1,10-菲咯啉)和[Cu(Met)(PIP)(ClO4)](ClO4)(3)(PIP=2-苯基-咪唑并[4,5-f]1,10-菲咯啉)。采用电子吸收光谱和荧光光谱等方法研究了配合物与小牛胸腺DNA的相互作用,用凝胶电泳方法研究了配合物对pBR322DNA的氧化切割活性。结果表明,虽配合物与DNA的作用较弱,但多吡啶配体的平面大小可直接影响到配合物与DNA的相互作用,而氨基酸辅助配体可起到进一步的调控作用。     

柠檬酸-邻菲啰啉-稀土三元配合物的合成与表征

在无水乙醇溶液中,以邻菲啰啉(Phen)、柠檬酸(H3Cit)为配体,合成了7种稀土三元固体配合物.通过元素分析、摩尔电导率测定、红外光谱和热重差热分析等手段确定配合物的组成为RE(Cit)·Phen·2H2O(RE=La3+,Pr3+,Nd3+,Sm3+, Eu3+,Tb3+,Dy3+).     

镧、钇掺杂铕-樟脑酸-1,10-菲咯啉三元配合物的合成及荧光性能

实验合成了单核铕-樟脑酸-1,10-菲咯啉三元配合物和La、Y掺杂异核铕-樟脑酸-1,10-菲咯啉三元配合物。通过配位滴定、元素分析和红外光谱等测试,确定其组成为RE2(CA)3(phen)2(RE为Eu、La和Y;CA为樟脑酸;phen为1,10-菲咯啉);通过三维荧光光谱图确定其最佳激发波长为330.0 nm,即在330.0 nm激发光下的发射光谱图中均显示出Eu3+离子5D0→7F0(579nm),5D0→7F1(594 nm)和5D0→7F2(612 nm)等三条特征谱线,其中5D0→7F2(612 nm)为最强跃迁峰。荧光强度变化研究表明,适量镧和钇离子的掺杂并没有降低铕离子的荧光强度,说明镧和钇对铕离子荧光发射有敏化作用。     

柠檬酸-邻菲哕啉-稀土三元配合物的合成与表征

在无水乙醇溶液中,以邻菲哆啉（Phen）、柠檬酸（H3Cit）为配体,合成了7种稀土三元固体配合物。通过元素分析、摩尔电导率测定、红外光谱和热重差热分析等手段确定配合物的组成为RE（Cit）·Phen·2H2O（RE=La^3＋,Pr^3＋,Nd^3＋,Sm^3＋,Eu^3＋,Tb^3＋,Dy^3＋）。     

二氰基二硫纶·邻菲咯啉-5,6-二酮混配锰(Ⅱ)、铁(Ⅱ)、钴(Ⅱ)配合物的感光氧化特性

测定了二氰基二硫纶·邻菲咯啉-5,6-二酮混配锰(Ⅱ)、铁(Ⅱ)、钴(Ⅱ)配合物MLL'(M=Mn2+、Fe2+、Co2+；L=mnt2-,1,2-二氰基乙烯-1,2-二硫醇离子；L'=phen-5,6-dione,1,10-邻菲咯啉-5,6-二酮)在二甲基亚砜(DMSO)、丙酮(Acet)和氯仿(CHCl3)中的电子...     

Tb3+、Eu3+,N-苯基邻氨基苯甲酸-1,10-邻菲咯啉配合物的发光性能研究

合成了一种新型的稀土Eu3+、Tb3+的N-苯基邻氦基苯甲酸-1,10-邻菲咯啉异多核配合物,通过红外光谱对其配位情况进行了表征,并用荧光光谱详细研究了其发光性能,讨论了配合物的分子内能量传递过程和电子转移之间的竞争.     

二氰基二硫纶·邻菲咯啉-5,6-二酮混配镍(Ⅱ)、铜(Ⅱ)、锌(Ⅱ)配合物的感光氧化特性

测定了二氰基二硫纶.邻菲咯啉-5,6-二酮混配镍(Ⅱ)、铜(Ⅱ)、锌(Ⅱ)配合物MLL′(L=mnt2-,1,2-二氰基乙烯-1,2-二硫醇离子L′=phen-5,6-dione,1,10-邻菲咯啉-5,6-二酮)在二甲基甲酰胺(DMF),丙酮(Acet.)和氯仿(CHCl3)中的电子吸收光谱,研究了电子光谱吸收带在相关分子轨道能级图中的对应跃迁关系,探讨了它们在DMF中的感光氧化特性。     

二环己酮草酰二腙桥联的双核钴(Ⅱ)配合物的合成、表征及电化学行为

合成了二种含二环己酮草酰二腙桥的双核钴配合物 [Co2 ( BCO) ( Mephen) 4]( Cl O4 ) 4( 1 )和[Co2 ( BCO) ( Me2 phen) 4]( Cl O4 ) 4( 2 )。BCO=二环己酮草酰二腙 ,Mephen=5-甲基 - 1 ,1 0 -邻菲咯啉 ,Me2 phen=2 ,9-二甲基 - 1 ,1 0 -邻菲咯啉。使用元素分析、摩尔电导以及红外光谱和电子光谱手段对配合物进行了表征 ,推定了配合物的组成和结构。并用循环伏安法研究了配合物 [Co2 ( BCO)( Mephen) 4]( Cl O4 ) 4的电化学行为     

Synthesis, characterization and antitumor activity of a series of polypyridyl complexes

A series of polypyridyl complexes have been synthesized. All polypyridyl complexes and some of the soluble ligands have been assayed for antitumor activity in vitro against the HL-60 (the human leucocytoma) cells, BEL-7402 (the human liver carcinoma) cells, KB (the human nasopharyngeal carcinoma) cells and HELA (the human adenocarcinoma of cervix) cells. The results indicate that several complexes have relative activity against different cell lines. Especially, the complexes [Co(bpy)(2)(pip)](3+), [Co(phen)(2)(pip)](3+), [Ru(bpy)(2)(pztp)](2+) and [Ru(pztp)(2)(bpy)](2+) show relative high activity against four tumor cell lines. Moreover, they are slightly more effective than cisplatin. At the concentration of 100 mug/mL, the complexes show inhibitory rate of 72 approximately 86% for the cancer cells and have no toxicity for MDCK and Vero cells. It is indicated that these complexes can inhibit cancer cells selectively.     

Transition and group IIb metal complexes with "active aldehyde" derivatives of thiamine

The Zn(2+), Cd(2+), Hg(2+), Co(2+) and Ni(2+) ions produce zwitterionic type complexes with the ligands (L), 2-(alpha-hydroxy-benzyl)thiamine=HBT and 2-(alpha-hydroxy-cyclohexyl-methyl)thiamine = HCMT, of the type MLCl(3). The ligands are in the S conformation, the metals are bound to N(1), of the pyrimidine moiety of thiamine and the complexes have a trigonally distorted tetrahedral structure, as the crystal structure of the complex Zn(HCMT)Cl(3) (orthorombic, a=14.4 b=14.1 c=17.4 beta=105.6(O) V=3392A(3) R=13.8%), the one and two dimensional (1)H nmr spectra of the Zn(2+), Cd(2+) and Hg(2+) complexes and the electronic spectra of the Co(2+) and Ni(2+) complexes show. A brief review of the previous techniques (structure of the Hg(HBT)Cl(3) complex, IR-Raman spectra, (13)C nmr in solution and solid state etc) used to characterize these complexes, is also given here and the proper conclusions drawn.     

Metal ion-binding properties of the diphosphate ester analogue, methylphosphonylphosphate, in aqueous solution

The stability constants of the 1:1 complexes formed between methylphosphonylphosphate (MePP(3-)), CH(3)P(O)(-) (2)-O-PO3(2-), and Mg(2+), Ca(2+), Sr(2+), Ba(2+), Mn(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+), or Cd(2+) (M(2+)) were determined by potentiometric pH titration in aqueous solution (25 degrees C; l = 0.1 M, NaNO(3)). Monoprotonated M(H;MePP) complexes play only a minor role. Based on previously established correlations for M(2+)-diphosphate monoester complex-stabilities and diphosphate monoester beta-group. basicities, it is shown that the M(Mepp)(-) complexes for Mg(2+) and the ions of the second half of the 3d series, including Zn(2+) and Cd(2+), are on average by about 0.15 log unit more stable than is expected based on the basicity of the terminal phosphate group in MePP(3-). In contrast, Ba(Mepp)(-) and Sr(Mepp)(-) are slightly less stable, whereas the stability for Ca(Mepp)(-) is as expected, based on the mentioned correlation. The indicated increased stabilities are explained by an increased basicity of the phosphonyl group compared to that of a phosphoryl one. For the complexes of the alkaline earth ions, especially for Ba(2+), it is suggested that outersphere complexation occurs to some extent. However, overall the M(Mepp)(-) complexes behave rather as expected for a diphosphate monoester ligand.     

Properties of Binuclear Rhodium(II) Complexes and Their Antibacterial Activity

Binuclear rhodium(II) complexes [Rh(2)Cl(2)(mu-OOCR)(2)(N-N)(2)], [Rh(2)(mu-OOCR)(2)(N-N)(2)(H(2)O)(2)](RCOO)(2) and [Rh(2)Cl(2)(mu-OOCCH(3))(terpy)(2)](H(3)O)Cl(2).9H(2)O (R = H, Me, Bu(n), ph, PhCHOH; N-N = 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-phenanthroline (dmp) and 6,7-dimethyl-2,3- di(2-pyridyl)quinoxaline (dmpq); terpy 2,2':6',2'-terpyridine) have been synthesized and their structure and properties have been studied by electronic, IR and (1)H NMR spectroscopy. Antibacterial activity of these complexes against Staphylococcus aureus and Escherichia coli has been investigated. The most active antibacterial agents against S. aureus were [Rh(2)(OOCPh)(2)(phen)(2)(H(2)O)(2)](2+), [Rh(2)(OOCPh)(2)(dmpq)(2)(H(2)O)(2)](2+), [Rh(2)(OOCBu)(2)(phen)(2)(H(2)O)(2)](2+) and [Rh(2)-(OOCBu)(2)(bpy)(2)(H(2)O)(2)](2+) which were considerably more active than the appropriate nitrogen ligands. The complexes show rather low activity against E. coli.     

钴(Ⅱ)、镍(Ⅱ)、铜(Ⅱ)与2,4-二羟基二苯甲酮配合物的合成与表征

以2,4-二羟基二苯甲酮(BP)为配体与M2+(M=Co,Ni,Cu)合成了几种新的配合物,研究了配合物的热稳定性。通过元素分析、IR、UV、TG-DTA和电导分析对配合物进行了表征。结果表明配合物的组成为M(BP)2.nH2O,配体中羰基氧和邻位羟基氧与中心离子配位构成平面正方形结构,三种配合物的热稳定性为:Co(Ⅱ)>Ni(Ⅱ)>Cu(Ⅱ)。     

Site-specific labelling of proteins with a rigid lanthanide-binding tag

This paper describes a generic method for the site-specific attachment of lanthanide complexes to proteins through a disulfide bond. The method is demonstrated by the attachment of a lanthanide-binding peptide tag to the single cysteine residue present in the N-terminal DNA-binding domain of the Escherichia coli arginine repressor. Complexes with Y(3+), Tb(3+), Dy(3+), Ho(3+), Er(3+), Tm(3+) and Yb(3+) ions were formed and analysed by NMR spectroscopy. Large pseudocontact shifts and residual dipolar couplings were induced by the lanthanide-binding tag in the protein NMR spectrum, a result indicating that the tag was rigidly attached to the protein. The axial components of the magnetic susceptibility anisotropy tensors determined for the different lanthanide ions were similarly but not identically oriented. A single tag with a single protein attachment site can provide different pseudocontact shifts from different magnetic susceptibility tensors and thus provide valuable nondegenerate long-range structure information in the determination of 3D protein structures by NMR spectroscopy.     

甘蔗汁酒精废液的色素稳定性

以色素吸光度的变化定量方法对以甘蔗汁酒精废液为原料提取得到的色素的稳定性进行了研究。结果表明,甘蔗汁酒精废液色素对Ca²⁺、Al³⁺、Mg²⁺、热、蔗糖、山梨酸钾以及柠檬酸具有良好的稳定性;而Fe³⁺、Fe²⁺、Cu²⁺、Zn²⁺、高pH值以及还原剂亚硝酸钠对色素具有不同程度的增色效果,其吸光度分别增加了72.72%、99.00%、21.73%、19.11%、13.31%、19.49%;氧化剂双氧水、还原剂维生素C、紫外光均可使色素产生不同程度的褪色,其吸光度较原来分别下降了87.56%、90.06%、30.54%。     

Solution Equilibria between Aluminum(III) Ion and L-histidine or L-tyrosine

Toxic effects due to high aluminum body loads were observed in a number of conditions following ingestion of Al-containing antacids. Bio-availability of aluminum depends not only on the solubility of the ingested salt but also on the physico-chemical properties of the soluble Al complexes formed in body fluids. Amino acids may, upon interaction with Al-salts, form absorbable Al-complexes. Hence, complex formation equilibria between Al(3+) and either, L- histidine or L-tyrosine were studied by glass electrode potentiometric (0.1 mol/L LiCl ionic medium, 298 K), proton NMR and uv spectrophotometric measurements. Non linear least squares treatment of the potentiometric data indicates that in the concentration ranges: 0.5相似文献   

Determination of biotransformation products of platinum drugs in rat and human urine

Cisplatin is an extremely effective cancer chemotherapeutic agent, but its use is often accompanied by toxicity. Second generation drugs such as carboplatin are becoming more widely used because of reduced toxicity. Since biotransformation products have been implicated in the toxic responses, we have begun to investigate the reactions of cisplatin and carboplatin with potential biological ligands. Reaction products were characterized using HPLC with inductively coupled plasma - mass spectrometry (HPLC-ICP-MS), (1)H and (13)C NMR and fast atom bombardment - mass spectrometry (FAB-MS). Three Pt-creatinine complexes, cis-[Pt(NH(3))(2)Cl(Creat)](+), cis-[Pt(NH(3))(2)(H(2)O)(Creat)](2+) and cis-[Pt(NH(3))(2)(Creat)(2)](2+), were synthesized and the platinum was shown to coordinate to the ring nitrogen, N(3). Human urine samples from patients on cisplatin chemotherapy were shown to contain cisplatin, its hydrolysis product and biotransformation products containing Pt-creatinine, Pt-urea and Pt-uric acid complexes. Urine from carboplatin patients shows fewer biotransformation products. Studies with control and diabetic (protected against cisplatin toxicity) rats showed systematic differences in the biotransformation products formed on administration of cisplatin.