快速灵敏的LC-MS/MS法测定人血浆中阿莫西林并应用于两种制剂的一致性评价

目的: 建立快速灵敏的LC-MS/MS法测定人血浆中阿莫西林浓度，并用于两种阿莫西林胶囊的一致性评价。方法: 采用岛津公司LCMS-8060型LC-MS/MS仪，以MRM模式测定阿莫西林（m/z 366.00/114.00）的浓度，d4-阿莫西林作内标（m/z 370.10/114.05），离子源为ESI源。色谱柱选用Waters ACQUITY BEH C18（2.1×50 mm，1.7 μm），梯度洗脱。血浆样本加入内标，经甲醇沉淀蛋白后取上清液进样检测。结果: 所建方法经验证，其线性、准确度、精密度、最低定量限、提取回收率、特异性、基质效应、稳定性等各项指标均符合CFDA的指导原则及最新核查标准要求，并较文献报道中的方法有处理简单、灵敏度高、色谱峰形好的优点。结论: 所建方法快速、灵敏，适用于人血浆中阿莫西林浓度的检测。用于一致性评价的样本实测，两种制剂生物等效。     

The sub-rating channel assignment strategy for PCS hand-offs

A new personal communications services (PCS) hand-off scheme is proposed. This scheme provides for hand-off to radio ports on which there is no free channel by “sub-rating” an existing connection. With sub-rating, an occupied full-rate channel is temporarily divided into two half-rate channels: one to serve the existing call and the other to serve the hand-off request. The blocking probabilities (combined forced terminations of existing calls and blocking of new call attempts) of this new scheme compare favorably with the standard scheme (nonprioritizing) and the previously proposed prioritizing schemes. The costs for this scheme are presented and discussed, as well as the additional procedural complexity of implementing on-the-fly sub-rating and the impact of continuing the conversation on a lower rate channel (which may lower speech quality of increase battery drain). Analytical models and simulations investigating the traffic impacts are presented, as are the results that show that even in the highest offered load considered a 3-min conversation in the busy hour experiences less than half a second of sub-rated conversation on average and only about 3% of the calls experience more than 5.12 s of sub-rated conversation. This scheme can increase capacity by 8-35% for systems with 1% call incompletion probability     

A push mechanism for GPRS supporting private IP addresses

The General Packet Radio Service (GPRS) provides a packet switched data service for mobile users. However, the existing GPRS specification does not provide the push mechanism and it is difficult to support GPRS services such as call termination (incoming call) for wireless voice over IP (VoIP). Based on the short message service, this paper proposes a push mechanism for GPRS supporting private IP addresses. Our approach does not need to modify the existing GPRS structure.     

Thermal Characterization of 1.3 μm InAsP/InGaAsP Ridge Waveguide MQW Lasers Based on Spectroscopy Method

An experimental way to analyze the thermal characterization of semiconductor lasers based on spectroscopy method under pulse driving conditions has been developed. By using this way the thermal characteristics of strain compensated 1.3 μm InAsP/InGaAsP ridge waveguide MQW laser diodes have been investigated. Results show that by measuring and analyzing the lasing spectra under appropriate driving parameters and temperature ranges, the thermal resistance of the laser diodes could be deduced easily. A higher thermal resistance of 640 K/W has been measured on a narrow ridge laser chip without soldering. Other thermal and spectral properties of the lasers have also been measured and discussed.     

Implicit deregistration in a PCS network

Registration/deregistration is required in a PCS network when a portable moves between registration areas. Several schemes were proposed to deregister a portable after it moves out of a registration area (RA). A simple scheme called implicit deregistration totally eliminates network traffic due to deregistration. However, this scheme may delete valid registration records. Thus, the size of a registration database must be sufficiently large to ensure low probability that a valid registration record is deleted. This paper describes an analytic model to determine the size k of the registration database for an RA in the implicit deregistration scheme. If the expected number of portables in an RA is N, then our study indicates that good performance can be achieved if k≃5N     

A comparison study of the two-tier and the single-tier personal communications services systems

A two-tier PCS system integrates the high tier PCS system and the low tier PCS systems into a single system to provide the advantages of both tiers. Such a system is expected to provide better service (more available and more cost effective to the users) at the expense of the extra tier switching management. We compare the performance of the two-tier PCS system and the single low tier system in two aspects: the registration traffic and the service availability. Because of the tier management, the two-tier system generates more registration traffic than the single low tier system. Under the range of the input parameters in our study, we show that the two-tier system generates less than 10% extra registration traffic than the single low tier system in most cases and generates less than 20% registration traffic in the worst cases. It is clear that for the service availability, the two-tier system is better than the single one tier system. We also study the probability that a call is forced terminated in the single low tier system because the low tier becomes unavailable during the call (such a call can be continued in the two-tier system).     

《C语言程序设计》教学中问题和改进方法的探讨

《C语言程序设计》是计算机专业学习中的一门基础的课程．是培养学生对计算机学习兴趣的关键课程。提出C语言教学过程中存在的一些问题。对问题进行分析,提出解决问题的方法。根据笔者的多年的教学实践,阐述一些教学方法和教学经验,对教师在教学思路和方法上有一定的指导意义,能够更好地提高教学水平。     

智能交通信号控制系统初探

城市交通拥挤是当今世界普遍关注的问题,它所带来的严重危害日益影响到人们的日常生活和社会经济的发展,而城市交通信号控制系统对解决这一问题发挥着不可替代的作用。从高性能智能交通信号控制系统的要求出发,针对目前我国城市交通问题的现状．对智能交通信号协调控制系统进行初步的研究和探讨。     

基于ATmega128单片机的汽车太阳能充电控制器

利用车上太阳能电池驱动换风扇并作为汽车电瓶辅助充电电源。由ATmega128为核心构成太阳能电池驱动换风扇和电瓶充电的控制系统。这个控制器测量车内外温度、太阳能电池电压、汽车电瓶电压,根据车内外温差自动控制换气风扇工作,根据太阳能电池输出状态和电瓶状态控制充电过程。最后,基于给出的软硬件设计构建了实验系统,进行了实验和总结。     

基于智能变电站远动通信的自动对点调试系统

基于远动通信框架,采用模块化思想,以四遥、图像及告警信息为对象,本文将厂站仿真实验平台、调度主站平台的功能分成不同的模块,可直观体现出自动对点的行为逻辑.其中,每一个模块独立开发且互不干扰,相互之间具有可借鉴性,在很大程度上降低了开发难度.在校验检测中,本文采用循环冗余算法,其与和校验法相比略复杂,但准确度更高.由此构建出一套智能变电站远动快速自动对点系统,以保证智能变电站的可靠运行.