Application of iot medical image detection and prenatal genetic testing in obstetric clinic

The use of new techniques and methods can be significantly improved during prenatal examination and screening of fetal genetic abnormalities. Expanding the number of vectors in screening and screening for single-cell gene diseases in fetal DNA will increase the probability of success of the whole screening test.Recently, sub chromosomal abnormalities have been introduced into prenatal care. The lack of suitable tools makes it very difficult to obtain information about collection, management, and prenatal genetic testing. The purpose of this study is to improve the accessibility of nutritional information by using the advantages of advanced medical image detection and integrating the IoT (Internet of Things) and prenatal genetic testing platforms in obstetric outpatient clinics. Records are kept that the platform will allow IoT to interact with sensor practitioners and provide immediate access to medical images prior to delivery. This proposed system provides an IoT application for managing obstetric outpatient information and prenatal genetic testing requirements. The requirement for establishment is the realization of the development of an IoT platform for complete medical image detection information management with IoT input required for integration with existing medical information systems. In response, the purpose of the study is to use integrated IoT applications to help nutrition professionals, researchers, patients, and especially mothers, to enhance their collection of medical imaging and prenatal genetic testing IoT sensor based information transfer.     

基于“CDIO”的“1+2”新教学模式研究

“CDIO”教学是将工程思维训练融合在教学各个环节当中,本文采用“CDIO”与“案例教学、启发教学”进行融合,组合成为一个新的“1+2”教学模式,以医学信息工程学院课程作为应用载体,将传统教学升华到工程思维教学、团队教学上,转变教师授课形式,激励和引导学生自主学习,为学生提供思维的空间和意境,帮助学生在学习时发现问题,发现、解决值得解决的问题,掌握计算在问题解决过程中发挥的作用,获得构建自身学科知识体系,终身自我学习的能力,滋生创新能力,达到学科知识与工程思维能力互相促进,共同提高的目的。     

医学信息工程专业毕业设计过程质量控制的研究

毕业设计是实践教学的重要环节,由于其教学进度涉及的时间跨度较长,且教学过程多数贯穿在学生实习、考研及就业准备过程中,加之异地化的指导和管理较为困难,若缺乏行之有效的监督极易发生质量问题。本文以医学信息工程专业的毕业设计为例,从毕业设计各阶段的过程质量控制具体措施,配合线上教学管理平台的质量监督体系来研究切实提高毕业设计过程质量的有效办法。     

Degradability and biocompatibility of bioglass/poly(amino acid) composites with different surface bioactivity as bone repair materials

Bioglass (BG) possesses excellent bioactivity and has been widely used in the manufacture of biomaterials. In this study, a composite with different surface bioactivity was fabricated via in situ melting polymerization by incorporating BG and poly(amino acid) (PAA) at a suitable ratio. The structure of the composite was characterized by Fourier transform infrared spectroscopy and XRD. The compressive strength of the BG/PAA composites was 139 MPa (BG:PAA = 30:70). The BG/PAA composites were degradable, and higher BG in composite showed higher weight loss after 4 weeks of incubation in simulated body fluid. In addition, the BG/PAA composite maintained adequate residual compressive strength during the degradation period. The SEM results showed the differences in surface bioactivities of the composites directly, and 30BG/PAA composite showed thicker apatite layer and higher Ca/p than 15BG/PAA. in vitro MG-63 cell culture experiments showed that the composite was noncytotoxic and thus allows cells to adhere, proliferate, and differentiate. This indicates that the composite has good biocompatibility. The implantations in the bone defects of rabbits for 4 and 12 weeks were studied. The composites had good biocompatibility and were capable of guiding new bone formation without causing any inflammation. The composite may be successfully used in the development of bone implants.     

Influence of CuO addition to BaSm2Ti4O12 microwave ceramics on sintering behavior and dielectric properties

Microwave dielectric ceramics of tungsten–bronze-type BaSm₂Ti₄O₁₂ were prepared by doping CuO (up to 2 wt.%) as the liquid-phase sintering aid. The effects of CuO additive on the densification, micro structure and dielectric properties were investigated. Due to the liquid-phase effect, the sintering temperature of BaSm₂Ti₄O₁₂ ceramics with 1 wt.% CuO addition can be effectively reduced to 1160 °C, about 200 °C lower than that of pure BaSm₂Ti₄O₁₂ ceramics, while good microwave dielectric properties of ɛ_r = 75.8, Q*f = 4914.6 GHz and τ_f = −7.65 ppm/°C were still achieved.     

The rapid selecting of precursor ions and product ions of thirty-four kinds of pesticide for content determination by GC–EI/MS/MS

Pesticide residues caused great threat to human body health, and all countries protected the health of human body by specifying its upper limit. However, pesticide residues were generally very low, similar to trace analysis and as low as millionth or less, the content determination of pesticide residues was a troublesome problem. With the application and promotion of tandem mass spectrometry, it was able to do trace analysis. GC–EI/MS/MS was a common method for the determination of pesticide residues. The multiple reaction monitoring (MRM) mode was the most common quantitative method used in GC–EI/MS/MS. It has the characteristics of high sensitivity, good reproducibility, high accuracy, strong anti-interference and high ion flux. Multiple-twin precursor ions, product ions and collision energy of thirty-four pesticides were provided for MRM. It could play an important role in developing MRM method for the quantifying of 34 kinds of pesticide. Meanwhile, the development of MRM method for the quantifying of other compounds could also refer to this paper.     

Quality evaluation of Hanyuan Zanthoxylum bungeanum Maxim. Using computer vision system combined with artificial neural network: A novel method

A novel technology based on computer vision system (CVS) and artificial neural network (ANN) was developed for the quality evaluation of Hanyuan Zanthoxylum bungeanum Maxim (HZB). The quality evaluation of HZB mainly depended on its colour, odour substances, and impurities. In this study, the contents of volatile oil (VOC), total alkylamides (TALC) and impurities (IMC) were determined and used as indices for quality control of HZB. Furthermore, CVS was also performed to determine the colour parameters (RGB values) and further transforms to CIE L*, a^*, and b*. Then, ANN was carried out to analyse the correlations between colour values obtained by CVS and quality parameters of HZB (VOC, TALC, and IMC). Higher performance and stability were presented by using CVS for determining the coloristic values of HZB. In addition, the present results also showed that the established method based on ANN could be used to predict the VOC, TALC, and IMC of HZB with the R² values of 0.9991, 0.9995, and 0.9998, respectively. This novel technology based on CVS combined with ANN could be used for the rapid, non-destructive, and effective evaluation of the quality of HZB.     

A reliable and sensitive time-resolved fluorescent immunochromatographic assay (TRFICA) for ochratoxin A in agro-products

Immunochromatographic assays (ICAs) are considered as a suitable diagnostic tool for the detection of mycotoxins. Mycotoxins and especially, ochratoxin A are analytes with more demanding sensitivity requirements. To enhance the sensitivity of current immunochromatographic assays for ochratoxin A (OTA), a novel sensitive ICA was developed in this study. In the assay, microspheres enclosing fluorescent europium (III) [Eu(III)] nanoparticles (EuNPs) were used as a label for OTA monoclonal antibody (OTA-mAb) conjugation. Accordingly, assay was called time-resolved fluorescent immunochromatographic assay (TRFICA). The test strip was composed of three parts: a sample pad, nitrocellulose membrane and an absorbent pad. As for detection, a proper concentration of conjugated microspheres was pipetted into the microtube and sample extract was added to it. Then the strip was inserted into the tube and the fluid flow along the strip. The TRFICA results were obtained in 8 min and read by a portable TRFICA strip reader. The established method allows quantitative determination of OTA with limit of detection as low as 1.0 μg kg⁻¹ in the samples. For validation, spiked samples including wheat, maize, soybean and rice were respectively assayed by TRFICA and a standard high performance liquid chromatography equipped with a fluorescence detector (HPLC-FLD), and good agreement of results was obtained between two methods.     

Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis

Plant lectins have been investigated to elucidate their complicated mechanisms due to their remarkable anticancer activities. Although plant lectins seems promising as a potential anticancer agent for further preclinical and clinical uses, further research is still urgently needed and should include more focus on molecular mechanisms. Herein, a Naïve Bayesian model was developed to predict the protein-protein interaction (PPI), and thus construct the global human PPI network. Moreover, multiple sources of biological data, such as smallest shared biological process (SSBP), domain-domain interaction (DDI), gene co-expression profiles and cross-species interolog mapping were integrated to build the core apoptotic PPI network. In addition, we further modified it into a plant lectin-induced apoptotic cell death context. Then, we identified 22 apoptotic hub proteins in mesothelioma cells according to their different microarray expressions. Subsequently, we used combinational methods to predict microRNAs (miRNAs) which could negatively regulate the abovementioned hub proteins. Together, we demonstrated the ability of our Naïve Bayesian model-based network for identifying novel plant lectin-treated cancer cell apoptotic pathways. These findings may provide new clues concerning plant lectins as potential apoptotic inducers for cancer drug discovery.     

Elasticity and adhesion of thin films by a mechanical resonance method

We describe a simple experimental apparatus capable of simultaneous measurements of elastic and anelastic properties of film/substrate composites in controlled atmospheres (10^-6-10⁴ Pa) from 25 to 1000°C. The apparatus employs the technique of dynamic resonance in which the mechanical response of a material can be determined over a wide range of frequency (0.1–100 kHz) with a resolution of ±1 μHz. We present experimental results for thin films (approximately 100 nm) of nickel and gold on sapphire substrates. These results demonstrate the sensitivity of the apparatus to both the adhesion and the elasticity of the supported film.