Validation of performance of real-time kinematic PPP. A possible tool for deformation monitoring

Structural failures (bridge or building collapses) and geohazards (landslides, ground subsidence or earthquakes) are worldwide problems that often lead to significant economic and loss of life. Monitoring the deformation of both natural phenomena and man-made structures is a major key to assessing structural dynamic responses. Actually, this monitoring process is under real-time demand for developing warning and alert systems.One of the most used techniques for real-time deformation monitoring is the Global Navigation Satellite System (GNSS) real-time procedure, where the relative positioning approach, using a well-known reference station, has been applied.This study was conducted to evaluate the actual quality of the real-time kinematic Precise Point Positioning (PPP) GNSS solution for deformation monitoring, where it can be concluded that a promise tool is under development and should be taken into account on actual and near future real-time deformation monitoring studies and applications.     

3S技术应用现状与发展趋势

3S技术出现至今,已在诸多领域成功运用并产生了巨大的价值。文章简单介绍了3S三大组成部分:GIS、RS、GNSS的基本概念,分析了3S技术目前在农业、生态环境监测、土地资源管理以及智慧城市方面的应用现状以及对其在该方面未来的发展趋势进行展望。最后对目前3S在应用中遇到的一些问题进行了探讨,给未来3S技术的发展提供一些参考。     

Extracellular Vesicles in CNS Developmental Disorders

The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics.     

The high-resolution time-of-flight spectrometer TOFTOF

The TOFTOF spectrometer is a multi-disc chopper time-of-flight spectrometer for cold neutrons at the research neutron source Heinz Maier-Leibnitz (FRM II). After five reactor cycles of routine operation the characteristics of the instrument are reported in this article. The spectrometer features an excellent signal to background ratio due to its remote position in the neutron guide hall, an elaborated shielding concept and an s-shaped curved primary neutron guide which acts i.a. as a neutron velocity filter. The spectrometer is fed with neutrons from the undermoderated cold neutron source of the FRM II leading to a total neutron flux of 10¹⁰n/cm²/s in the continuous white beam at the sample position distributed over a continuous and particularly broad wavelength spectrum. A high energy resolution is achieved by the use of high speed chopper discs made of carbon-fiber-reinforced plastic. In the combination of intensity, resolution and signal to background ratio the spectrometer offers new scientific prospects in the fields of inelastic and quasielastic neutron scattering.     

惯性导航装置虚拟检测仪设计

惯性导航装置是一种很重要且精密的设备,故障检测和诊断是设备维修的前提,综合采用现在的虚拟检测技术,对惯性导航装置的故障检测方法进行了研究,设计了虚拟检测仪的硬件设备,开发了虚拟检测仪的软件,完成了整个虚拟检测仪的设计。     

多模卫星信号模拟器设计与实现

应用卫星导航、软件无线电、计算机控制、电磁兼容等技术,研制了基于"工控机+DSP+FPGA"架构的多模卫星信号模拟器;该模拟器在国内最先实现了GPS、GLONASS和北斗一号信号的任意组合、时空同步仿真;详细论述了模拟器硬件方案,介绍了其软件构成和各模块功能,最后通过成熟商业多模接收机验证了模拟器所仿真信号的有效性和任意时空性;此外,该模拟器无需更改硬件即可在未来向北斗二号系统扩展。     

μC／OS—Ⅲ在Cortex—M3处理器上的移植

为了将μC／OS-Ⅲ移植到Cortex—M3处理器上,选用RealView MDK作为软件开发平台,针对Cortex—M3处理器特性编写了移植所需的C语言和汇编语言源代码,并验证了移植的正确性。移植后的μC／OS-Ⅲ能够稳定运行于Cortex～M3处理器上。该移植对大部分Cortex—M3处理器具有通用性,对其他架构处理器的μC／OS-Ⅲ移植具有参考作用。     

水平阻尼作为干扰的平台式惯导统一控制方程

研究惯导系统统一控制的优化设计。传统的统一控制采用一体化设计方案,通用性不强。为简捷高效地实现惯导计算机的程序编排,提出了将水平阻尼作为干扰项的平台式惯导统一控制。通过改变系统框图结构,将无阻尼惯导系统和阻尼网络人为分离,水平阻尼网络的输出可视为干扰项。系统控制方程始终采用无阻尼条件下的表达式,惯导系统控制和阻尼网络可以实现模块化设计,使控制的实现形式和推导过程大为简化。给出了惯导计算机的运算流程,并分别在静、动基座条件下,对无阻尼、内水平阻尼和外水平阻尼状态的惯导系统做了仿真。结果表明新的统一控制模型有效体现了惯导系统的参数变化,且设计简便,具有更好的实用性。     

曲线运动SAR成像算法研究

研究合成孔径雷达曲线运动时的优化成像质量问题。提出了一种结合了惯导加速度参数和根据回波数据两种运动补偿曲线运动合成孔径雷达成像算法,提高了成像质量。首先研究了合成孔径雷达曲线运动时的目标模型,分析了惯性导航系统的原理,并以频谱分析的子孔径成像为基础,加入运动补偿等辅助处理。进行仿真,根据一组仿真参数和曲线轨迹生成仿真回波数据,证明仿真成像算法的有效性。系统运算简单,可为曲线运动时的合成孔径雷达实时信号处理系统系统设计提供依据。     

Advances in Applying Computer-Aided Drug Design for Neurodegenerative Diseases

Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools.