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1.
Dong Liu Xia Ke Zhong-Ce Hu Yu-Guo Zheng 《Journal of Bioscience and Bioengineering》2021,131(5):518-524
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Ava Kwong Cecilia Y. S. Ho Vivian Y. Shin Chun Hang Au Tsun Leung Chan Edmond S. K. Ma 《International journal of molecular sciences》2021,22(2)
The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe a patient who was a 48-year-old female identified with biallelic pathogenic mutations of the BRCA1 gene, with no or very subtle FA-features. She was diagnosed with ovarian cancer and breast cancer at the ages of 43 and 44 and had a strong family history of breast and gynecological cancers. 相似文献
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The uniaxial tension experiments are performed on thermoplastic polyurethane to investigate its mechanical behaviors and related potential mechanisms, and the loading strain rate is designing to be wide ranging from 0.0001 to 1 s−1. It is found that the polyurethane presents an obvious rate-dependence, and the stress strain curves share distinct strain hardening characteristics under the investigated strain rates. Furthermore, the strain hardening ratios are sharing nearly same trends and appear to be influenced by both strain rate and the induced adiabatic heating. Besides, the ratio is also strain-dependent on previous loading history. Then, a two-dimension unit cell model is built to investigate potential equivalent mechanisms, of which the hard phase as inclusion is equivalent with crystallization zone, crosslinking sites, and so forth. The simulation results facilitate to explain the distinct strain hardening ratios, even for the matrix from the extrapolated curves under super-low strain rate loading. Finally, the analogic mechanisms of equivalent hard inclusions are proposed, which can reasonably explain the strain rate- and strain-dependence characteristics of polyurethane mechanical behaviors. 相似文献
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《Food Control》2015
In this work a multicommuted flow system employing copper–4,4′- dipyridyl coordination compound as the solid-phase reagent for the spectrophotometric determination of reducing sugar was developed. The coordination compound was synthesized through a reaction of the 4,4′-dipyridyl and copper (II) nitrate, under hydrothermal conditions. The complex was characterized by infrared spectroscopy (FTIR), power X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectrometer (EDS) and thermogravimetric analysis (TGA). Based on the characterization, a multicommuted spectrophotometric procedure for the determination of reducing sugar using copper (II) complex as solid reagent is proposed. The proposed method was based on the redox reaction between a monosaccharide, such as fructose and glucose (reducing sugar) and Cu(II). This reaction, mediated in an alkaline medium, produces a yellow compound that can be determined by absorption electronic spectroscopy (λABS = 420 nm). Under optimum experimental conditions, a linear response ranging from 1.0 to 20.0 g L−1 (R = 0.9978 and n = 5), a detection (3σ criterion) and quantification (10σ criterion) limit estimated at 0.23 and 0.75 g L−1, respectively, a standard deviation relative of 4.7% (n = 7), for a reference solution of 10.0 g L−1 reducing sugar, and a sampling rate of 75 determinations per hour were achieved. The proposed system was applied to the determination of reducing sugars in coconut water and juices. The analysis of ten samples and the application of the t-test to the results found, and those obtained using reference procedures (AOAC), provided no significant differences at a 95% confidence level. This system enabled the analysis of reducing sugar with ease and simplicity, providing a significant economy of the solid reagent (600 μg per determination) and reducing effluent generation. 相似文献
7.
Lorena Rodríguez-López Myriam Rincón-Fontán Xanel Vecino Ana B. Moldes Jose M. Cruz 《Journal of surfactants and detergents》2020,23(1):79-90
Over the last few years, the global biosurfactant market has raised due to the increasing awareness among consumers, for the use of biological or bio-based products. Because of their composition, it can be speculated that these are more biocompatible and more biodegradable than their chemical homologous. However, at the moment, no studies exist in the literature about the biodegradability of biosurfactants. In this work, a biosurfactant contained in a crude extract, obtained from a corn wet-milling industry stream that ferments spontaneously in the presence of lactic acid bacteria, was subjected to a biodegradation study, without addition of external microbial biomass, under different conditions of temperature (5–45 °C), biodegradation time (15–55 days), and pH (5–7). For that, a Box–Behnken factorial design was applied, which allowed to predict the percentage of biodegradation for the biosurfactant contained in the crude extract, between the range of the independent variables selected in the study, obtaining biodegradation values between 3 and 80%. The percentage of biodegradation for the biosurfactant was calculated based on the increase in the surface tension of samples of the crude extract. Furthermore, it was also possible to predict the variation in t1/2 for the biosurfactant (time to achieve the 50% of biodegradation) under different conditions. 相似文献
8.
以钙系生料釉为基础,引入结晶剂CuO、MnO2制备无铅CuO-MnO2系金属光泽釉;结合XRD、SEM-EDS进行物相组成定性分析和显微结构表征,系统探究外加TiO2、V2O5以及玻璃粉对金属光泽釉釉面分相的影响。研究表明:一定量的TiO2、V2O5引入能有效促进釉面的分相,将玻璃粉部分替换基础釉中的钾长石能使得釉熔体的高温粘度降低,并进一步加剧釉面分相,促进CuMn2O4铜锰尖晶石在釉层表面的析出和富集;当TiO2引入量为2%,V2O5引入量为1%,玻璃粉引入量为25%(同为质量分数)时,金属光泽釉釉面效果最佳。 相似文献
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针对卫星激光通信粗跟踪系统的跟踪稳定精度指标要求高的特点,建立了基于永磁同步电机直接驱动的粗跟踪系统模型并进行了跟踪稳定误差分析。在采用传统PID控制策略存在跟踪误差较大、动态性能较差等不足的基础上,提出了一种基于粗跟踪系统的改进型前馈复合控制策略。从理论上分析了前馈复合控制策略提高了粗跟踪系统的动态性能,为降低跟踪稳定误差提供了改善方案。地面实验验证结果表明,与传统控制策略相比,改进型复合控制策略极大地降低了系统的动态跟踪误差,动态跟踪误差由606μrad降低至13μrad(1δ)。进一步的在轨实验也验证了改进型复合控制策略的合理性和先进性,总体指标满足了卫星激光通信终端的极高精度要求。本文所提出的控制策略对其他高性能跟踪伺服系统设计也具有较大的借鉴意义。 相似文献