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采用超高效液相色谱-线性离子阱-串联静电轨道阱高分辨质谱(UHPLC-LTQ-Orbitrap HRMS)法对薄荷水提物中4种类群化学成分进行分析鉴定。选取Acquity UPLC~BEH C18色谱柱(2.1mm×100mm×1.7μm),以乙腈-0.1%甲酸水溶液为流动相,流速0.30mL/min,梯度洗脱分析。根据高分辨质谱提供的准分子离子峰和碎片离子信息,获取目标化合物的相对分子质量和结构信息,并结合保留时间、对照品分析、参考文献数据和ClogP值等相关信息,鉴定了85种化学成分,包括38种黄酮、16种酚酸、7种苯丙素和24种萜类。结果表明,采用UHPLC-LTQ-Orbitrap HRMS技术能够提高中药化学成分的分析效率,该方法可为合理开发薄荷的药用和食用价值奠定化学基础。 相似文献
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以得到淫羊藿黄酮苷酶解产物中的未知次生苷为目的,利用大孔吸附树脂SP207对淫羊藿黄酮苷酶解产物进行分离.结果表明,用70%的乙醇洗脱,可大量富集目标产物;目标产物经硅胶柱层析,最终得到目标产物单体0.161 g,经高效液相色谱测定,纯度达到99%. 相似文献
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用正交实验法优化采用超临界CO2技术萃取车前草中熊果酸的工艺条件。在单因素实验基础上,采取L9(3^3)探讨萃取压力、萃取温度、CO2流量对萃取车前草熊果酸的得率的影响情况,确定了超临界CO2萃取车前草中熊果酸的适宜条件。超临界萃取最优条件为:萃取压力35MPa,萃取温度为40℃,选择无水乙醇为夹带剂,夹带剂质量分数为20%,萃取时间2h,CO2流量为20L/h,产品的出膏率为3.58%,萃取物中熊果酸的含量为6.93%。该法与传统方法相比,具有操作简便快速,溶剂用量少,有效成分提取率高等优点。 相似文献
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Analysis of volatile components in herbal pair (HP) herba schizonepetae-ramulus cinnamomi (HS-RC), single herb HS and RC was carried out by gas chromatography-mass spectrometry (GC-MS) data and chemometric resolution method (CRM). The two-dimensional data obtained from GC-MS instruments were resolved into a pure chromatogram and a mass spectrum of each chemical compound by CRM. In total, 47, 61 and 51 chemical components in volatile oil of HS, RC, and HP HS-RC were respectively determined qualitatively and quantitatively, accounting for 90.52%, 88.37%, and 88.72% total contents of volatile oil of HS, RC, and HP HS-RC, respectively. The number of the volatile components of HP HS-RC is almost the addition of that of two single herbs, but their relative contents are changed. 相似文献
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随着现代生活水平的不断提高,人们对于化妆品的质量和性能要求也越来越高,希望研发出对人体健康无害,同时又具有美容保健作用的天然护肤化妆品。结合中药益母草的结构特性,阐述了其通过清除人体内的过氧化物和自由基,使人体细胞免受伤害,在养颜美容、抗衰老以及防辐射等方面具有显著的功效。近年来随着研究的不断拓展,益母草在药妆品领域将会拥有广阔的应用前景。 相似文献
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综述了对白花蛇舌草的抗肿瘤成分、作用机制、药理、临床应用等方面的研究进展,为进一步研究白花蛇舌草提供理论和实验指导。 相似文献
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旱莲草对酪氨酸酶激活作用的动力学研究 总被引:10,自引:0,他引:10
酪氨酸酶是黑素生物合成途径中的主要限速酶,旱莲草有促进酪氨酸酶活性的作用。通过对旱莲草的水提液和乙醇提取液促进酪氨酸酶活性作用的观察研究及旱莲草提高酪氨酶活性的动力学观察研究,得到lineweaver-burk曲线,动力学回归方程及米氏Km值。为进一步研究中药用效成分能使白发变黑的分子机理奠定了基础。 相似文献
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Maya B. Kostova Kalina I. Alipieva Simeon S. Popov Nedyalka V. Handjieva 《仪器科学与技术》2013,41(6):691-702
Abstract Five C10 iridoid glycosides (shanzhiside methyl ester, lamalbide, lamiide, sesamoside, and 5‐desoxysesamoside) were examined by electrospray ionization mass spectrometry (ESI‐MS). Considerable differences were observed in positive ion and negative ion mode. Only the positive ion spectra were useful for molecular mass determination on the basis of molecular alkali metal adducts, with the exception of two iridoids containing all 5β‐OH, 7β‐OH and 8β‐OH groups. Fragment characteristics for distinct functionalities were observed. Chelation studies of each iridoid with three different alkali metals were also conducted. 相似文献