Granulation Tissue Enhanced with Aspirin and Omega-3 PUFAs as a Local Adjunct to the Surgical Treatment of Periodontitis

The topical application of aspirin and omega-3 polyunsaturated fatty acids (PUFAs) may trigger the resolution of inflammation by inducing the biosynthesis of pro-resolvers such as lipoxins and resolvins while also avoiding the side effects of systemic aspirin intake. This study assessed the effect of enhanced granulation tissue (EGT) on periodontal tissue regeneration through the local application of aspirin and omega-3 PUFAs directly to granulation tissue (GT) during periodontal surgery. This randomized controlled experiment assesses 38 pockets in 19 patients. In every patient, two similar intrabony periodontal defects are treated with an open flap debridement, one with EGT (GT extracted, enhanced with aspirin and omega-3 PUFAs, and replaced) and the other with standard GT removal. Clinical attachment level (CAL) and probing pocket depth (PPD) are assessed at baseline and 2 and 6 months after surgery. The experimental protocol (EGT) results in a greater CAL gain as compared to that in the controls at 6 months (p < 0.05), while PPD reduction is not affected. The retained GT does not compromise healing. EGT is proposed as a promising, inexpensive, and simple method that may improve the outcome of periodontal regenerative treatment. However, the described protocol requires optimization and further assessment. Practical Applications : The biosynthesis of mediators including resolvins and lipoxins triggered by aspirin and omega-3 PUFAs promote the resolution of inflammation, eventually leading to faster regeneration of inflamed tissues. While granulation tissue is a necessary component in wound healing, enhancing granulation tissue with aspirin and omega-3 PUFAs results in CAL gain in the surgical treatment of periodontal defects. Retained granulation tissue does not compromise periodontal healing. The EGT strategy is an inexpensive and simple method that may improve the clinical outcomes of regenerative periodontal procedures.     

Twin screw granulation – review of current progress

Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but generally with little comparison of results. A certain degree of confidence has been developed through these studies related to how process variables and many attributes of machinery configuration will affect granulation but some major challenges still lay ahead related to scalability, variations in the processing regimes related to degree of channel fill and the impact of wetting and granulation of complex powder formulations. This review examines the current literature for wet granulation processes studied in twin screw extrusion machinery, summarizing the influences of operational and system parameters affecting granule properties as well as strives to provide some practical observations to newly interested users of the technique.     

Preparation of CaO granules using the granulation method

ABSTRACT

Improving the hydration resistance of CaO particle in manufacturing and application of free CaO-containing materials has practical significance. In this study, CaO granules was made from Ca(OH)₂ particles, which were fabricated by the granulation method. The results showed that the hydration resistance of the CaO granules which was prepared under 1700?r?min^?1 was the best, the CaO granules was sintered well in calcination process, the shell of CaO granules was relatively dense, which improves the hydration resistance of CaO granules, and the rate of hydration weight increment was 0.58% after placed in the air for 20 days under a temperature of 10–14°C and a relative humidity of 57–81%.     

大颗粒尿素造粒工艺简介

介绍了大颗粒尿素造粒工艺，着重介绍了荷兰NSM公司的流化床造粒技术和法国K－T公司的流化床转鼓造粒（FDG）技术。     

Synthesis and characterization of zeolite NaY from rice husk silica

Rice husk silica (RHS) in amorphous phase with 98% purity was prepared from a waste rice husk from rice milling by leaching with hydrochloric acid and calcination. The RHS was used effectively as a silica source for the synthesis of zeolite Y in sodium form (NaY). The zeolite in pure phase was obtained from a two-step synthetic route in which the starting gels were mixed, aged for 24 h at room temperature and crystallized for 24 h at 90 °C. The diameter of single crystal particles from a scanning electron microscope was approximately 1.0 μm, whereas the average particle diameter from laser diffraction particle size analyzer was approximately 10 μm because of the agglomeration of small crystals. Longer crystallization time in this route resulted in a mixed phase containing NaY and zeolite P in sodium form (NaP). In addition, a one-step synthetic route (no aging) was studied and the product was also a mixed phase zeolite.     

广钢3#高炉大修炉渣处理工艺探讨与分析

本文对处理高炉炉渣的图拉法工艺设计进行了总结，并对广钢3#高炉使用中出现的问题做了分析，生产实践表明，该工艺安全可靠，水渣质量好，而且有利于环境保护。     

丙酮低压一步法合成甲基异丁基酮催化剂体系研究进展

对丙酮低压一步法合成甲基异丁基酮所需要的催化剂体系及反失活机理进行了详尽的综述，并对近年来的研究工作进行了系统地分析与比较，提出了未来的研究方向。     

尿素熔融喷浆造粒工艺在复合肥生产过程中存在的问题及对策

介绍在团粒法工艺的基础上，将尿素熔融成尿液进行喷浆造粒生产复合肥的过程中，存在的问题，原因及解决的对策。     

Characterization of one-step,chromate-free,primer systems using liquid-state Si and C NMR

Coatings derived from organofunctional silanes have been investigated as possible replacements for the chromate-based systems used in the aerospace industry. In this study, organofunctional silanes [bis-(triethoxysilylpropyl)ethane and bis(triethoxysilylpropyl) tetrasulfide] were reacted with commercially available acrylate (ECO-CRYL™ 9790) and epoxy (EPI-REZ™ WD-510) resins, resulting in a one-step, low-VOC, chromate-free primer. Liquid-state ²⁹Si and ¹³C NMR were used to determine structural characteristics of various optimized formulations.     

Optimal control of nonlinear systems to given orbits

Using optimal control techniques we derive and demonstrate the use of an explicit single-step control method for directing a nonlinear system to a target orbit and keeping it there. We require that control values remain near the uncontrolled settings. The full nonlinearity of the problem in state space variables is retained. The “one-step” of the control is typically a composition of known or learned maps over (a) the time required to learn the state, (b) the time to compute the control and (c) the time to apply the control. No special targeting is required, yet the time to control is quite rapid. Working with the dynamics of a well-studied nonlinear electrical circuit, we show how this method works efficiently and accurately in two situations: when the known circuit equations are used, and when control is performed only on a Poincaré section of the reconstructed phase space. In each case, because the control rule is known analytically, the control strategy is computationally efficient while retaining high accuracy. The target locations on the selected target trajectory at each control stage are determined dynamically by the initial conditions and the system dynamics, and the target trajectory is an approximation to an unstable periodic orbit of the uncontrolled system. A linear stability analysis shows that dissipation in the dynamical system is essential for reaching a controllable state.