TiO2/MXene-Assisted LDI-MS for Urine Metabolic Profiling in Urinary Disease

Cancer remains an intractable medical problem. Rapid diagnosis and identification of cancer are critical to differentiate it from nonmalignant diseases. High-throughput biofluid metabolic analysis has potential for cancer diagnosis. Nevertheless, the present metabolite analysis method does not meet the demand for high-throughput screening of diseases. Herein, a high-throughput, cost-effective, and noninvasive urine metabolic profiling method based on TiO₂/MXene-assisted laser desorption/ionization mass spectrometry (LDI-MS) is presented for the efficient screening of bladder cancer (BC) and nonmalignant urinary disease. Combined with machine learning, TiO₂/MXene-assisted LDI-MS enables high diagnostic accuracy (96.8%) for the classification of patient groups (including 47 BC and 46 ureteral calculus (UC) patients) from healthy controls (113 cases). In addition, BC patients can also be identified from noncancerous UC individuals with an accuracy of 88.3% in the independent test cohort. Furthermore, metabolite variations between BC and UC individuals are investigated based on relative quantification, and related pathways are also discussed. These results suggest that this method, based on urine metabolic patterns, provides a potential tool for rapidly distinguishing urinary diseases and it may pave the way for precision medicine.     

变长线扫描选择性激光烧结快速成型工艺的质量和效率优势分析

本文分析变长线扫描选择性激光烧结快速成型工艺对点扫描工艺的质量和效率优势.对二者光学系统结构作分析对比,对焦斑和线束上的功率密度作计算对比.变长线扫描系统采用的扫描方式和聚焦元件使线束宽度小且恒定,线束功率密度与点扫描焦斑的相当.变长线扫描选择性激光烧结快速成型工艺的质量优势是明显的,效率比点扫描工艺提高一倍左右.     

大窝山隧道进口围岩快速掘进施工组织与管理

结合工程概况及工程特点,从机械设备配置、劳动力组织、现场管理等方面介绍了大窝山隧道进口Ⅱ级,Ⅲ级围岩段的快速掘进施工组织与管理措施,为类似隧道的快速掘进施工组织与管理提拱了相关经验.     

EFFECT OF STREAMLINE CURVATURE AND SOME OTHER CONDITIONS ON THE TURBULENT STRUCTURES IN THE OTHER REGION OF AN OBSTACLE

ＥＦＦＥＣＴＯＦＳＴＲＥＡＭＬＩＮＥＣＵＲＶＡＴＵＲＥＡＮＤＳＯＭＥＯＴＨＥＲＣＯＮＤＩＴＩＯＮＳＯＮＴＨＥＴＵＲＢＵＬＥＮＴＳＴＲＵＣＴＵＲＥＳＩＮＴＨＥＯＴＨＥＲＲＥＧＩＯＮＯＦＡＮＯＢＳＴＡＣＬＥＬｉｕＳｈｉ－ｈｅ（ＷｕｈａｎＵｎｉｖｅｒｓｉｔ...     

房屋建筑结构无损检测方法的分析与展望

通过对现有的结构无损检测方法的总结和分析,讨论了各种方法的优缺点.并结合现场测试的要求,展望结构检测技术的发展方向与趋势.     

Extracting Electron Densities in N-Type GaAs From Raman Spectra: Theory

In this paper, we present the theory for calculating Raman line shapes as functions of the Fermi energy and finite temperatures in zinc blende, n-type GaAs for donor densities between 10¹⁶ cm⁻³ and 10¹⁹ cm⁻³. Compared to other theories, this theory is unique in two respects: 1) the many-body effects are treated self-consistently and 2) the theory is valid at room temperature for arbitrary values of the ratio R = (Q²/α), where Q is the magnitude of the normalized wave vector and α is the normalized frequency used in the Raman measurements. These calculations solve the charge neutrality equation self-consistently for a two-band model of GaAs at 300 K that includes the effects of high carrier concentrations and dopant densities on the perturbed densities of states used to calculate the Fermi energy as a function of temperature. The results are then applied to obtain the carrier concentrations from Fermi energies in the context of line shapes in Raman spectra due to the coupling between longitudinal optical phonons and plasmons. Raman measurements have been proposed as a non-destructive method for wafer acceptance tests of carrier density in semiconductor epilayers. The interpretation of Raman spectra to determine the majority electron density in n-type semiconductors requires an interdisciplinary effort involving experiments, theory, and computer-based simulations and visualizations of the theoretical calculations.     

隧道二次衬砌混凝土快速施工技术

结合某隧道施工实例，阐述了混凝土快速施工方案，探索了采用机械化混凝土输送系统配合整体液压衬砌台车进行混凝土快速施工技术，并提出了系统的设计、选形与配套措施。     

某半导体产品的设计和快速实现研究

研究了产品开发及快速实现过程中任务获取、任务分配、进度的协调、信息传输等相关问题,并以某半导体产品为例,进行了产品的设计和快速实现,为缩短产品开发和上市周期、提高产品的市场竞争力积累经验。     

Structure of rapidly solidified aluminum alloys

This paper is a summary of an extensive research program carried out by the authors on the structure of rapidly solidified aluminum alloys; and a comparison with the work of others also involved in this field. The paper discusses the changes in the dendritic and non-dendritic structure of the matrix at cooling rates from 10^–3 to 10¹⁰ K/s and discusses the hetergeneity of the structure caused by interdendritic-segretion during solidification.     

深过冷熔体激发快速定向凝固

阐述了深过冷的方法，深过冷的遗传性，深过冷度的理论极限以及深过冷熔体激发发快速定向凝固的试验方法及其凝固过程，给出了深过冷熔体（Ｃｕ－５ｗｔ％）激发快速定向凝固与铸态试验激发快速定向凝固的初步试验结果。