Antibacterial activity and action target of phenyllactic acid against Staphylococcus aureus and its application in skim milk and cheese

Phenyllactic acid (PLA) has been demonstrated to possess antibacterial activity and capacity to prolong food shelf life. However, studies on the performance of PLA in inhibiting Staphylococcus aureus and its effectiveness when applied to dairy products are largely lacking. Here, antibacterial activity (planktonic and biofilm states) of PLA against S. aureus CICC10145 (S. aureus_45) were investigated. The results showed that PLA inhibited growth of S. aureus_45 and formation of S. aureus_45 biofilm. Next, the antibacterial action target of PLA was uncovered from both physiological and phenotypic perspectives. The results showed that PLA decreased cell metabolic activity and cell viability, damaged cell membrane integrity, triggered leakage of intracellular contents (DNA, proteins, and ATP), and caused oxidative stress damage and morphological deformation of S. aureus_45. In practical application, the antibacterial activity of PLA against S. aureus_45 cells was further confirmed in skim milk and cheese as dairy food models, and the antibacterial effects can be adequately maintained during storage for 21 d, at least at 4°C. These findings suggested that PLA could be a potential candidate for controlling S. aureus outgrowth in dairy foods.     

Advancements in the Development of non-BET Bromodomain Chemical Probes

The bromodomain and extra terminal (BET) family of bromodomain-containing proteins (BCPs) have been the subject of extensive research over the past decade, resulting in a plethora of high-quality chemical probes for their tandem bromodomains. In turn, these chemical probes have helped reveal the profound biological role of the BET bromodomains and their role in disease, ultimately leading to a number of molecules in active clinical development. However, the BET subfamily represents just 8/61 of the known human bromodomains, and attention has now expanded to the biological role of the remaining 53 non-BET bromodomains. Rapid growth of this research area has been accompanied by a greater understanding of the requirements for an effective bromodomain chemical probe and has led to a number of new non-BET bromodomain chemical probes being developed. Advances since December 2015 are discussed, highlighting the strengths/caveats of each molecule, and the value they add toward validating the non-BET bromodomains as tractable therapeutic targets.     

High-resolution ISAR imaging of fast rotating targets based on pattern-coupled Bayesian strategy for multiple measurement vectors

Very high resolution inverse synthetic aperture radar (ISAR) imaging of fast rotating targets is a complicated task. There may be insufficient pulses or may introduce migration through range cells (MTRC) during the coherent processing interval (CPI) when we use the conventional range Doppler (RD) ISAR technique. With compressed sensing (CS) technique, we can achieve the high-resolution ISAR imaging of a target with limited number of pulses. Sparse representation based method can achieve the super resolution ISAR imaging of a target with a short CPI, during which the target rotates only a small angle and the range migration of the scatterers is small. However, traditional CS-based ISAR imaging method generally faced with the problem of basis mismatch, which may degrade the ISAR image. To achieve the high resolution ISAR imaging of fast rotating targets, this paper proposed a pattern-coupled sparse Bayesian learning method for multiple measurement vectors, i.e. the PC-MSBL algorithm. A multi-channel pattern-coupled hierarchical Gaussian prior is proposed to model the pattern dependencies among neighboring range cells and correct the MTRC problem. The expectation-maximization (EM) algorithm is used to infer the maximum a posterior (MAP) estimate of the hyperparameters. Simulation results validate the effectiveness and superiority of the proposed algorithm.     

基于微博用户兴趣话题的相似用户挖掘

相似用户挖掘是提高社交网络服务质量的重要途径，在面向大数据的社交网络时代，准确的相似用户挖掘对于用户和互联网企业等都有重要的意义，而根据用户自己的兴趣话题挖掘的相似用户更符合相似用户的要求。提出了一种基于用户兴趣话题进行相似用户挖掘的方法。该方法首先使用TextRank话题提取方法对用户进行兴趣话题提取，再对用户发表内容进行训练，计算出所有词之间的相似度。提出CP（Corresponding Position similarity）、CPW（Corresponding Position Weighted similarity）、AP（All Position similarity）、APW（All Position Weighted similarity）四种用户兴趣话题词相似度计算方法，通过用户和相似用户间关注、粉丝重合率验证相似用户挖掘效果，APW similarity的相似用户的关注/粉丝重合百分比为1.687%，优于提出的其他三种算法，分别提高了26.3%、2.8%、12.4%，并且比传统的文本相似度方法Jaccard相似度、编辑距离算法、余弦相似度分别提高了20.4%、21.2%、45.0%。因此APW方法可以更加有效地挖掘出用户的相似用户。     

基于分段加权的反向稀疏跟踪算法研究

为提高稀疏表示跟踪模型性能，提出一种分段加权的反向稀疏跟踪算法，将跟踪问题转化为在贝叶斯框架下寻找概率最高的候选对象问题，构造不同的分段权重函数来分别度量候选目标与正负模板的判别特征系数。通过池化来降低跟踪结果的不确定性干扰，选择正负模板加权系数差值最大的候选表示作为跟踪结果。实验表明，在光照变化、遮挡、快速运动、运动模糊情况下，所提出的算法可以确保跟踪结果的准确性和鲁棒性。     

Collective institutional work: the case of Airbnb in Amsterdam,London and New York

ABSTRACT

Given that online platforms disrupt established industries and challenge existing institutions, they can only be successful if their innovation becomes both legal and legitimate. This requires ‘institutional work’ that changes perceptions and regulations within society. Rather than only focussing on the online platform as the sole agent engaging in institutional work, our study analyses institutional work as a collective process. We investigate the case of home-sharing platform Airbnb and the process of institutional change its introduction prompted regarding short-term rental in Amsterdam, London and New York. We find, contrary to the popular view of online platforms as disruptive entrepreneurs, that the platform mainly focusses on creating new institutions rather than disrupting existing ones, and that users and non-users undertake most of the institutional work activities. We also show that different types of actors carry out different types of institutional work suggesting that the process of institutional work is highly distributed.     

应用膨胀算法提取目标的直接定位算法

为了解决被动雷达系统中的多发射源定位问题，提出了一种基于多重信号分类(MUSIC)算法和图像膨胀(IE)算法的直接定位方法。该方法结合了谱分析中的MUSIC思想，通过对接收量测协方差矩阵进行特征分析求解目标的位置。首先，在目标个数未知的前提下，利用Akaike信息准则(AIC)来确定模型阶数；然后，推导了基于MUSIC的定位代价函数；之后，利用图像膨胀算法处理得到的代价函数平面；最后，膨胀处理后的输出为目标个数及目标位置的估计值。提出的算法有效地解决了目标检测及提取的问题，能够确定多个目标的位置坐标，为后续的定位性能分析提供可能性，也保证了算法的完整性。进一步地分析了多个临近目标情况下影响目标提取性能的主要因素。     

基于时空的弱点状运动目标检测技术

如何在复杂背景下持续有效地检测目标位置,一直是研究者们需要面对的主要挑战。本文在研究红外点状移动目标特征的基础上,根据目标无纹理,无形状的特性,提出一种改进的形态学目标增强算法,并利用目标连续时空不变性检测目标。首先,建立多尺度的图像金字塔,在每层上采用改进的形态学算法快速、粗糙定位小目标。然后进一步的根据目标在时空上的位置相关性,提出基于目标运动特征分析的精确检测方法。得到精确稳定的检测结果。最后实验结果表明与经典的形态学检测算法及其他算法相比,该技术能更有效地检测弱小目标,具有更高的鲁棒性。     

Influences of Ga concentration on performances of CuInGaSe2 cells fabricated by sputtering-based method with ceramic quaternary target

Copper Indium Gallium Selenide (Cu(In,Ga)Se₂, CIGSe) absorbers with different Ga contents were prepared by sputtering CIGSe ceramic targets and post-annealing. CIGSe solar cell devices were fabricated with other functional layers. The device performances and absorber properties were investigated. Increasing Ga content led to an increase in V_OC and a decrease in J_SC. Ga was supposed to diffuse towards back contact during the annealing process. The best performance was obtained as the ratio of Ga/(In + Ga) reaches 0.32 with the efficiency of 13.8% and a V_OC of 537 mV.     

山东栖霞—大柳行地区金矿找矿靶区地质评价及优选

栖霞—大柳行地区位于胶东中部栖霞—蓬莱金矿成矿带内，是胶东重要的金成矿区，成矿条件优越。为了对圈定靶区进行优选分类，通过对该区地质背景、找矿靶区评价、找矿靶区优选方面展开综合研究，并结合勘查工作程度和矿业权设置情况，划分出3类预测区，选定了5个靶区为今后优先部署勘查工作的方向。