超声波辅助合成离子液体及其性能研究

以超声波辅助法合成了离子液体1丁-基-3-甲基咪唑氟硼酸盐([BM Im]BF4),对产物进行了光谱分析、电导率和粘度测定,并考察了其酯化反应的催化性能.实验结果表明:该合成方法具有合成条件简单、反应时间短、能耗低、易纯化等优点.[BM Im]BF4在甲醇中的最大紫外吸收波长为213 nm,IR图谱与文献报道吻合;分别以丙酮、无水乙醇和乙酸乙酯为溶剂,测得[BM Im]BF4的极限摩尔电导率分别为237.94 S·cm2·mol -1、47.22 S·cm2·mol-1和1.5411 S·cm2·mol-1.     

Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors

1. Diadenosine hexaphosphate (AP6A) exerts vasoconstrictive effects. The purpose of this study was to investigate whether AP6A has any effect on cardiac function. 2. The effects of AP6A (0.1-100 microM) on cardiac contractility and frequency were studied in guinea-pig and human isolated cardiac preparations. Furthermore, the effects of AP6A on the amplitude of the L-type calcium current, on the adenosine 3':5'-cyclic monophosphate (cyclic AMP) content and on the phosphorylation of regulatory phosphoproteins, i.e. phospholamban and troponin inhibitor, were investigated in guinea-pig isolated ventricular myocytes. 3. In isolated spontaneously beating right atria of the guinea-pig AP6A exerted a negative chronotropic effect and reduced the rate of contraction maximally by 35% (IC20 = 35 microM). 4. In isolated electrically driven left atria of the guinea-pig AP6A exerted a negative inotropic effect and reduced force of contraction maximally by 23% (IC20 = 70 microM). 5. In isolated electrically driven papillary muscles of the guinea-pig AP6A alone was ineffective, but attenuated isoprenaline-stimulated force of contraction maximally by 23% (IC20 = 60 microM). Furthermore, AP6A attenuated the relaxant effect of isoprenaline. 6. In human isolated electrically driven ventricular preparations AP6A alone was ineffective, but attenuated isoprenaline-stimulated force of contraction by maximally 42% (IC20 = 18 microM). Moreover, AP6A attenuated the relaxant effect of isoprenaline. 7. All these effects of AP6A were abolished by the selective A1-adenosine receptor antagonist 1,3-dipropyl-cyclopentyl-xanthine (DPCPX, 0.3 microM), whereas the M-cholinoceptor antagonist atropine (10 microM) and the P2-purinoceptor antagonist suramin (300 microM) failed to abolish the effects of AP6A. 8. AP6A 100 microM had no effect on the amplitude of the L-type calcium current, but attenuated isoprenaline-stimulated L-type calcium current. The maximum of the current-voltage relationship (I-V curve) was shifted to the left by isoprenaline and additional application of AP6A shifted the I-V curve back to the right to the control value. The phosphorylation state of phospholamban and the troponin inhibitor was unchanged by AP6A alone, but was markedly attenuated by AP6A in the presence of isoprenaline. Cyclic AMP levels remained unchanged by AP6A, even after stimulation with isoprenaline. 9. In summary, AP6A exerts negative chronotropic and inotropic effects in guinea-pig and human cardiac preparations. These effects are mediated via A1-adenosine receptors as all effects were sensitive to the selective A1-adenosine receptor antagonist DPCPX. Furthermore, the effects of AP6A on cyclic AMP levels, protein phosphorylation and the L-type calcium current are in accordance with stimulation of A1-adenosine receptors.     

Unexpected return of spontaneous circulation after cessation of resuscitation (Lazarus phenomenon)

The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-beta]pyridine NPhIP) is a major dietary component in individuals eating cooked meats or fish. This heterocyclic amine requires biochemical activation, mainly through cytochrome P4501A2, and can be detoxified chiefly by 4'hydroxylation through other cytochromes, and be in turn converted through phase 2 enzymes to readily excreted conjugates. The active form of PhIP is mutagenic in Salmonella typhimurium TA98 and is a useful substrate to study the possible chemoprotective action of phytochemicals. We found that black and green tea depressed the mutagenicity of PhIP in dose-related fashion, and decaffeinated tea was less powerful an inhibitor. This led to the study of caffeine, that displayed effective dose-related inhibition of the mutagenicity of PhIP. Other antioxidants such as lycopene, the active antioxidant from tomatoes, and daidzein and genistein from soy products, also had a dose-related inhibition of the mutagenicity of PhIP. We conclude that PhIP is a good substrate found in several human foods to determine the protective effect of phytochemicals from vegetables, and beverages.     

浓缩~(235)U诱发免疫细胞凋亡的电镜和琼脂糖凝胶电泳研究

研究了浓缩235U内照射诱发人淋巴细胞白血病细胞株Molt－4细胞和巨噬细胞株Ana－1细胞的细胞调亡。估算了浓缩235U在不同阶段培养细胞中的辐射累积吸收剂量。通过电镜对免疫细胞的形态观察，发现Molt－4和Ana－1细胞在受235U内照射作用下可呈现核染质边聚，DNA链断裂和膜包裹的凋亡小体形成。对Molt－4和Ana－1细胞的DNA抽提，进行DNA琼脂糖凝胶电泳也显示出阶梯状条带形成的细胞调亡特征。从而证实了浓缩235U内照射可导致免疫细胞Molt－4和Ana－1细胞的凋亡发生。     

异步交叉轧制能耗特性研究

对异步交叉轧制的能耗特性进行了分析与实验验证.研究表明,随交叉角增大,轧制能耗下降,当交叉角(θ)增至临界值(θcr)时,能耗最小,交叉角θ＞θcr后,能耗基本不变;随异步比增大,能耗亦下降,当异步比(i)增至临界值(icr)时,能耗最小, i＞icr后,能耗则上升,且θ愈大, icr亦愈大.即当交叉角为θcr且异步比亦为icr时,异步交叉轧制综合能耗最小.     

基于小波分析的光纤陀螺信号处理

文章对光纤陀螺仪的实测信号进行了分析。为了抑制光纤陀螺随机噪声,利用五点三次平滑、数字滤波、小波变换分析法对光纤陀螺静态输出数据进行了滤波处理,通过对比滤波前后陀螺的输出曲线、标准差以及频谱图,可以发现:小波阈值滤波和五点三次平滑相结合的方法能够有效的补偿光纤陀螺的随机误差。     

基于模糊聚类的半自动跟踪技术研究

现有半自动跟踪系统将操作员等效为准线性环节,增大了训练的难度和成本,不适应复杂战场环境下多个快速机动目标的选取和跟踪.利用特征提取方法得到视场的“潜在目标”集,引入模糊聚类方法,通过对操作响应进行分类,建立操控意图与目标运动特征之间的关系模型.通过充分的仿真试验,对比研究了跟踪平稳性、快速性、准确性等指标,结果说明该方法能够有效提升整体跟踪性能.     

基于COM＋技术的Web服务封装研究

早期的信息管理系统都是用于实现企业特定的业务功能而建立的,包括对企业生产、供应、销售以及客户服务等的控制和管理。企业按照职能部门建立了各种企业信息系统,这些信息管理系统被其所在部门所使用,并在实际的工作生产中发挥了巨大作用。该文从整体考虑各个企业信息管理系统,并根据具体业务的需求对这些系统进行统一编排,通过一个合适的集成平台把现有企业信息管理系统进行有机的整合起来,使各＂信息孤岛＂联系起来。     

最坏情况下X3SAT最大海明距离问题最小上界

X3SAT最大海明距离问题是指对于一个X3SAT问题实例,寻找该问题的任意两组可满足赋值之间的最大海明距离。提出了一个基于DPLL的精确算法HMX来求解X3SAT最大海明距离问题,根据公式中某个变量在两组真值赋值中的不同取值进行分支。给出了多种化简规则,这些规则很好地提高了算法的时间效率。证明了该算法可以将X3SAT最大海明距离问题的最小上界由目前最好的O(1.7107n)缩小到O(1.6760n),其中n为公式中变量的数目。     

基于混沌PSO的动态可重构系统软硬件划分

软硬件划分是动态可重构系统软硬件协同设计中的关键技术之一,如何兼顾划分效率和划分效果,达到两者的最佳结合是软硬件划分的主要问题.在考虑动态部分重构及重构延时等特征的基础上,提出一种微粒群优化算法与混沌优化算法相结合的混沌微粒群软硬件划分方法.该算法使用基于实数编码的微粒群优化算法执行全局搜索,再根据搜索结果采用混沌优化算法执行局部搜索,具有较强的全局搜索和跳出局部最优的能力.仿真实验表明,该算法比标准微粒群算法和遗传算法具有更好的有效性和快速性,能够有效地实现应用任务图到可重构系统的时空映射.