电梯层门的定期检验及案例分析

层门属于电梯的重要部件之一,它把乘客和井道、轿厢进行有效隔离,让乘客拥有一个安全良好的使用空间,有效保障乘梯人员的安全性和舒适性.层门若在带病情况下运行,乘坐电梯的人员将面临严重的安全威胁,甚至造成剪切、坠落等事故,因此乘客的乘梯安全很大程度上取决于电梯层门是否处于正常使用状态.为确保层门能够充分发挥出自身功能,减少甚至避免因层门引起的事故发生,层门的安全检验成为主要的研究对象.简要阐述了层门的结构形式,重点介绍了层门检验的主要对象和检验细节,最后对检验过程中碰到的层门滑块与防脱钩装置不能契合、层门副门锁动作不可靠两则案例进行分析探讨,为后期的检验提供参考.     

全尾砂和废石联合胶结充填体最佳配比及应用

针对红岭铅锌矿分级充填骨料来源不足、地表废石堆积污染环境的情况,提出将该矿选厂产生的全尾砂和地表废石作为充填骨料的联合胶结充填方案。分别测试了全尾砂和地表废石的物理化学性质,验证了碎石和全尾砂作为联合充填骨料的可行性。通过充填配比试验,分析了不同配比全尾砂废石充填体强度特性,得出了最佳充填配比。结果表明,充填试块的强度随灰砂比减小而减小,随养护龄期增加呈增大趋势,随充填料浆质量浓度增大而增大,最佳配比为: 胶结充填灰砂比1∶8、普通充填灰砂比1∶12,全尾砂∶废石配比4∶6,质量浓度78%。根据研究结果,在红岭铅锌矿进行了全尾砂废石充填技术工业应用,证实该技术可行。     

In Silico Analysis and Experimental Validation of Active Compounds from Cichorium intybus L. Ameliorating Liver Injury

This study aimed at investigating the possible mechanisms of hepatic protective activity of Cichorium intybus L. (chicory) in acute liver injury. Pathological observation, reactive oxygen species (ROS) detection and measurements of biochemical indexes on mouse models proved hepatic protective effect of Cichorium intybus L. Identification of active compounds in Cichorium intybus L. was executed through several methods including ultra performance liquid chromatography/time of flight mass spectrometry (UPLC-TOF-MS). Similarity ensemble approach (SEA) docking, molecular modeling, molecular docking, and molecular dynamics (MD) simulation were applied in this study to explore possible mechanisms of the hepato-protective potential of Cichorium intybus L. We then analyzed the chemical composition of Cichorium intybus L., and found their key targets. Furthermore, in vitro cytological examination and western blot were used for validating the efficacy of the selected compounds. In silico analysis and western blot together demonstrated that selected compound 10 in Cichorium intybus L. targeted Akt-1 in hepatocytes. Besides, compound 13 targeted both caspase-1 and Akt-1. These small compounds may ameliorate liver injury by acting on their targets, which are related to apoptosis or autophagy. The conclusions above may shed light on the complex molecular mechanisms of Cichorium intybus L. acting on hepatocytes and ameliorating liver injury.