Cystic craniopharyngioma: long-term results after intracavitary irradiation with stereotactically applied colloidal beta-emitting radioactive sources

OBJECTIVE: Long-term follow-up data were analyzed to assess the value of intracavitary irradiation with stereotactically applied beta-emitting radioisotopes for the treatment of craniopharyngioma cysts. METHODS: Sixty-two of 70 consecutive patients with predominantly cystic craniopharyngiomas were selected for retrospective analysis. Beta-Emitting isotopes were injected intracystically using a computed tomography-guided and computer-assisted three-dimensional stereotactic treatment planning and application system (cumulative dose to the inner surface of the cyst wall, 200 Gy). RESULTS: The tumor response rate gained with yttrium-90-labeled silicate (66 of 78 cysts) or phosphorous-32-labeled chromic phosphate (8 of 78 cysts) was 79.5%. Four cysts treated with rhenium-186-labeled sulfate did not respond. Mean survival after intracavitary irradiation was 9.0 +/- 0.9 years (median follow-up, 11.9 yr). In patients with solitary cysts, the mean survival was 12.5 +/- 1.4 years (actuarial 5- and 10-yr survival rates, 80 and 64%, respectively). Six months postoperatively, visual deficits (38 of 62 patients) had improved in 23 patients and were stable in 15 patients. The side effects that occurred 6 to 12 months after treatment with yttrium-90 were complete blindness (three patients), worsening of visual field cuts (one patient), third nerve palsy (one patient), and diabetes insipidus and/or panhypopituitarism (three patients). CONCLUSIONS: Intracavitary irradiation using yttrium-90 or phosphorous-32 is highly effective in the treatment of cystic craniopharyngiomas. If applied as initial treatment in patients with solitary cysts, it is the only required therapy over a long period.     

Pulmonary hypertension in patients with obstructive sleep apnea syndrome

BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is associated with an increased cardiovascular morbidity, including pulmonary hypertension. Little is known about factors influencing the degree of pulmonary hypertension and left ventricular dysfunction in patients with OSAS, especially in the absence of concomitant lung disease. METHODS: Right heart catheterization, arterial blood gas analysis, and pulmonary function tests were performed in 92 consecutive patients (81 men and 11 women; mean +/- SD age, 53.1 +/- 11.0 years) with polysomnographically verified OSAS, in whom clinically significant lung disease was excluded. RESULTS: Eighteen patients (20%) had mild pulmonary hypertension; 8 (44%) of them also had increased pulmonary capillary wedge pressures (Ppew). Left ventricular dysfunction was associated with arterial hypertension. Only Ppcw (r = 0.51; P < .001) and the percentage of time during sleep spent with an oxygen saturation below 90% (as an indicator of the severity of OSAS) (r = 0.34; P = .003) were significantly and independently associated with pulmonary artery pressure. CONCLUSIONS: Obstructive sleep apnea syndrome can cause mild pulmonary hypertension, even in the absence of pulmonary disease. In these patients, pulmonary hypertension is of the postcapillary type, or-in patients with normal left ventricular function-strongly related to the severity of OSAS. Our findings indicate that OSAS may constitute an important, and independent, risk factor for pulmonary hypertension.     

Photorealistic 3D reconstruction from handheld cameras

One of the major challenges in the fields of computer vision and computer graphics is the construction and representation of life-like virtual 3D scenarios within a computer. The VISIRE project attempts to reconstruct photo-realistic 3D models of large scenarios using as input multiple freehand video sequences, while rendering the technology accessible to the non-expert. VISIRE is application oriented and hence must deal with multiple issues of practical relevance that were commonly overlooked in past experiences. The paper presents both an innovative approach for the integration of previously unrelated experiences, as well as a number of novel contributions, such as: an innovative algorithm to enforce closedness of the trajectories, a new approach to 3D mesh generation from sparse data, novel techniques dealing with partial occlusions and a method for using photo-consistency and visibility constrains to refine the 3D mesh. Tomas Rodriguez was born in Madrid in 1961. Bachelor in Physics and Master in Electronics by the Universidad Complutense de Madrid. He started his career in the private R&D sector in 1987, when he specialized in computer vision and parallel processing systems. In the early nineties he participated in the EVA project; one of the most outstanding traffic monitoring system of the time. For more than 10 years, he has been involved in international research projects within the ambit of EUREKA, ESPRIT, V and VI Framework programmes. During this time, he coordinated eight international projects (CAMELOT, CITRONE, ON-LIVE, SAID, VISIRE, EVENTS, ITALES, HOLONICS) and acted as principal investigator in two additional ones (CITRUS and VICTORIA). Since the early days, he had the opportunity to collaborate with some of the most prestigious research institutions in Europe: Franhoufer Inst., INRIA, CNRS, University of Oxford, University of Lund, DFKI, Siemens C-Lab, Philips Research Labs, etc. Evaluator of R&D projects for the Spanish Ministry for Science and reviewer of international scientific journals, he is currently the R&D manager and coordinator for European projects at Eptron SA. His recent interests include: computer vision, real time software, industrial control, parallel processing, iTV, and mobile technologies, etc.     

Cast iron-a predictable material

High strength compacted graphite iron (CGI) or alloyed cast iron components are substituting previously used non-ferrous castings in automotive power train applications.The mechanical engineering industry has recognized the value in substituting forged or welded structures with stiff and light-weight cast iron castings.New products such as wind turbines have opened new markets for an entire suite of highly reliable ductile iron cast components.During the last 20 years,casting process simulation has developed from predicting hot spots and solidification to an integral assessment tool for foundries for the entire manufacturing route of castings.The support of the feeding related layout of the casting is still one of the most important duties for casting process simulation.Depending on the alloy poured,different feeding behaviors and self-feeding capabilities need to be considered to provide a defect free casting.Therefore,it is not enough to base the prediction of shrinkage defects solely on hot spots derived from temperature fields.To be able to quantitatively predict these defects,solidification simulation had to be combined with density and mass transport calculations,in order to evaluate the impact of the solidification morphology on the feeding behavior as well as to consider alloy dependent feeding ranges.For cast iron foundries,the use of casting process simulation has become an important instrument to predict the robustness and reliability of their processes,especially since the influence of alloying elements,melting practice and metallurgy need to be considered to quantify the special shrinkage and solidification behavior of cast iron.This allows the prediction of local structures,phases and ultimately the local mechanical properties of cast irons,to asses casting quality in the foundry but also to make use of this quantitative information during design of the casting.Casting quality issues related to thermally driven stresses in castings are also gaining increasing attention.State-of-the-art tools allow the prediction of residual stresses and iron casting distortion quantitatively.Cracks in castings can be assessed,as well as the reduction of casting stresses during heat treatment.As the property requirements for cast iron as a material in design strongly increase,new alloys and materials such as ADI might become more attractive,where latest software developments allow the modeling of the required heat treatment.Phases can be predicted and parametric studies can be performed to optimize the alloy dependent heat treatment conditions during austenitization,quenching and ausferritization.All this quantitative information about the material’s performance is most valuable if it can be used during casting design.The transfer of local properties into the designer’s world,to predict fatigue and durability as a function of the entire manufacturing route,will increase the trust in this old but highly innovative material and will open new opportunities for cast iron in the future.The paper will give an overview on current capabilities to quantitatively predict cast iron specific defects and casting performance and will highlight latest developments in modeling the manufacture of cast iron and ADI as well as the prediction of iron casting stresses.     

Effects of packaging SrI2(Eu) scintillator crystals

Recent renewed emphasis placed on gamma-ray detectors for national security purposes has motivated researchers to identify and develop new scintillator materials capable of high energy resolution and growable to large sizes. We have discovered that SrI₂(Eu) has many desirable properties for gamma-ray detection and spectroscopy, including high light yield of ∼90,000 photons/MeV and excellent light yield proportionality. We have measured <2.7% FWHM at 662 keV with small detectors (<1 cm³) in direct contact with a photomultiplier tube, and ∼3% resolution at 662 keV is obtained for 1 in.³ crystals. Due to the hygroscopic nature of SrI₂(Eu), similar to NaI(Tl), proper packaging is required for field use. This work describes a systematic study performed to determine the key factors in the packaging process to optimize performance. These factors include proper polishing of the surface, the geometry of the crystal, reflector materials and windows. A technique based on use of a collimated ¹³⁷Cs source was developed to examine light collection uniformity. Employing this technique, we found that when the crystal is packaged properly, the variation in the pulse height at 662 keV from events near the bottom of the crystal compared to those near the top of the crystal could be reduced to <1%. This paper describes the design and engineering of our detector package in order to improve energy resolution of 1 in.³-scale SrI₂(Eu) crystals.     

Occurrence, distribution and fluxes of benzotriazoles along the German large river basins into the North Sea

Benzotriazole (BT) and tolyltriazole (TT) are high production volume chemicals which are used in various industrial and household applications. In this study, the distribution of benzotriazoles in the estuaries of different rivers of central Europe and in the North Sea was analyzed by solid-phase extraction (SPE) and liquid chromatography-mass spectrometry (HPLC-MS/MS). BT as well as TT was detected in all water samples. The concentrations for total benzotriazoles (BTs) ranged from 1.7 to 40 ng/L in the North Sea in costal areas. Concentrations in rivers are from 200 to 1250 ng/L, respectively. The mass flux of total benzotriazoles from the major rivers of central Europe into the North Sea was calculated to 78 t/a, dominated by the Rhine with an individual flux of 57 t/a of BTs. The analysis of the distribution profile in the North Sea showed that the decrease of the concentration was mostly caused by dilution and that the benzotriazoles are poorly degradable in the North Sea. This paper presents the first report of benzotriazoles in the marine environment.     

Process monitoring in real time: Empirical bayes approach—discrete case

In this paper an empirical Bayes model is developed to monitor and analyse discrete data generated in a manufacturing process for printed circuit boards. A key feature of this analysis is the use of the current observation at time t and the posterior estimates of the distribution of the proportion nonconforming at time t – 1 to obtain a new, updated estimate of the posterior distribution at time t. The derived approach is widely applicable to statistical process control and provides a simple and fast algorithm for updating.     

Linear matrix inequality formulation of spectral mask constraints with applications to FIR filter design

The design of a finite impulse response (FIR) filter often involves a spectral "mask" that the magnitude spectrum must satisfy. The mask specifies upper and lower bounds at each frequency and, hence, yields an infinite number of constraints. In current practice, spectral masks are often approximated by discretization, but in this paper, we derive a result that allows us to precisely enforce piecewise constant and piecewise trigonometric polynomial masks in a finite and convex manner via linear matrix inequalities. While this result is theoretically satisfying in that it allows us to avoid the heuristic approximations involved in discretization techniques, it is also of practical interest because it generates competitive design algorithms (based on interior point methods) for a diverse class of FIR filtering and narrowband beamforming problems. The examples we provide include the design of standard linear and nonlinear phase FIR filters, robust "chip" waveforms for wireless communications, and narrowband beamformers for linear antenna arrays. Our main result also provides a contribution to system theory, as it is an extension of the well-known positive-real and bounded-real lemmas.     

RTCVD growth and applications of epitaxial Si1−xGex alloys

Rapid thermal chemical vapor deposition (RTCVD) is a competing technology for the growth of Si_1?xGe_x strained-layer structures for the development of silicon-based heterojunctions. High-quality epitaxial films with growth temperatures as low as 600°C and 4.5 nm-period superlattices have been demonstrated without the use of ultrahigh-vacuum techniques. Narrow-bandgap-base heterojunction bipolar transistors made of Si/Si_1?xGe_x/Si have been shown to have superior characteristics compared to all-silicon homojunction devices, and extend the scaling limits of bipolar transistors. Finally, RTCVD strained Si_1?xGe_x films exhibit well-resolved band-edge photoluminescence—the first step on the way to developing silicon-based light-emitting devices.