Continuous cyclic zone adsorption

A theoretical study of a continuous version of the cyclic zone adsorption separation process, providing us with a new understanding of the parameters that determine the existence of a separation effect and its extent is presented. A mathematical model is proposed and then solved analytically. Conditions under which a separation effect can be achieved are established, leading to the definition of dimensionless parameters that control the process. Finally, optimal operating conditions are derived and discussed.     

Robust regression methods for computer vision: A review

Regression analysis (fitting a model to noisy data) is a basic technique in computer vision, Robust regression methods that remain reliable in the presence of various types of noise are therefore of considerable importance. We review several robust estimation techniques and describe in detail the least-median-of-squares (LMedS) method. The method yields the correct result even when half of the data is severely corrupted. Its efficiency in the presence of Gaussian noise can be improved by complementing it with a weighted least-squares-based procedure. The high time-complexity of the LMedS algorithm can be reduced by a Monte Carlo type speed-up technique. We discuss the relationship of LMedS with the RANSAC paradigm and its limitations in the presence of noise corrupting all the data, and we compare its performance with the class of robust M-estimators. References to published applications of robust techniques in computer vision are also given.     

On focusing matrices for wide-band array processing

A general class of transformation matrices for coherent signal-subspace processing is presented. These signal-subspace transformation (SST) matrices are shown to generate a sufficient statistic for maximum-likelihood bearing estimation. Two general forms for calculating SST matrices are presented, and the rotational signal-subspace (RSS) focusing matrices proposed by H. Hung and M. Kaveh (1988) are shown to be a special case of the SST matrices. An efficient procedure for computing a subset of the SST matrices, utilizing Householder transformations, is presented. The procedure reduces the computational load by a factor of 10, compared with that for the RSS matrices. The application of MUSIC to the coherently combined covariance matrix is also discussed, and Monte Carlo simulations comparing the performance of Householder SST matrices and RSS matrices are performed     

The diversity of potential cheese ripening characteristics of lactic acid starter bacteria: 2. The levels and subcellular distributions of peptidase and esterase activities

The levels and subcellular distributions of various peptidase and esterase activities in a range of lactococcal and Streptococcus thermophilus strains were investigated. There was no correlation between the levels of the enzymes in the different strains and the ability of the strains to produce acid when grown in milk. While considerable differences between individual strains were apparent, average levels of X-prolyldipeptidyl aminopeptidase, dipeptidase and tripeptidase were similar in the Lactococcus lactis subsp. lactis and L. lactis subsp. cremoris strains studied, while that of lysylaminopeptidase (i.e. activity assayed using lysine p-nitroanilide as substrate) in the L. lactis subsp. cremoris strains was approximately double that in the L. lactis subsp. lactis strains. The average levels of lysylaminopeptidase and X-prolyldipeptidyl aminopeptidase in the S. thermophilus strains studied were similar to those in the L. lactis subsp. cremoris strains, while the average levels of dipeptidase and tripeptidase were considerably lower. All peptidases studied were recovered predominantly in the cytoplasmic fraction, although in a few strains there was some evidence to suggest that a part of the tripeptidase activity may be associated with cell structures comprising the particulate fraction. The levels of esterase activity in the strains were considerably different between strains. However, the average level of esterase activity detected in the two lactococcal subspecies was similar, while that in the S. thermophilus strains was more than double the lactococcal average. The subcellular distribution of the esterase in all strains studied showed that a significant proportion of the activity is located on the cell surface.     

Archetypal organization of the amphioxus Hox gene cluster

Organization into gene clusters is an essential and diagnostic feature of Hox genes. Insect and nematode genomes possess single Hox gene clusters (split in Drosophila); in mammals, there are 38 Hox genes in four clusters on different chromosomes. A collinear relationship between chromosomal position, activation time and anterior expression limit of vertebrate Hox genes suggests that clustering may be important for precise spatiotemporal gene regulation and hence embryonic patterning. Hox genes have a wide phylogenetic distribution within the metazoa, and are implicated in the control of regionalization along the anteroposterior body axis. It has been suggested that changes in Hox gene number and genomic organization played a role in metazoan body-plan evolution, but identifying significant changes is difficult because Hox gene organization is known from only very few and widely divergent taxa (principally insects, nematodes and vertebrates). Here we analyse the complexity and organization of Hox genes in a cephalochordate, amphioxus, the taxon thought to be the sister group of the vertebrates. We find that the amphioxus genome has only one Hox gene cluster. It has similar genomic organization to the four mammalian Hox clusters, and contains homologues of at least the first ten paralogous groups of vertebrate Hox genes in a collinear array. Remarkably, this organization is compatible with that inferred for a direct ancestor of the vertebrates; we conclude that amphioxus is a living representative of a critical intermediate stage in Hox cluster evolution.     

Guidelines for the design and conduct of clinical trials on dentine hypersensitivity

Clinical trials on dentine hypersensitivity have been numerous and protocols varied. To date there is little consensus as to the conduct of studies on this poorly-understood yet common and painful dental condition. A committee of interested persons from academia and industry was convened to discuss the subject of clinical trials on dentine hypersensitivity and a consensus report is presented. A double-blind randomized parallel groups design is recommended, although cross-over designs may be used for the preliminary screening of agents. Subjects may have multiple sites scored. Sample size will be determined by estimating the variability in the study population, the effect to be detected and the power of the statistical test to be used. Subject selection is based on a clinical diagnosis of dentine hypersensitivity, excluding those with conflicting characteristics such as currently-active medical or dental therapy. The vestibular surfaces of incisors, cuspids and bicuspids are preferred as sites to be tested. A range of sensitivity levels should be included. Tactile, cold and evaporative air stimuli should be applied. Negative and benchmark controls should be incorporated. Most trials should last 8 weeks. Sensitivity may be assessed either in terms of the stimulus intensity required to evoke pain or the subjective evaluation of pain produced by a stimulus using a visual analog or other appropriate scale. The subject's overall assessment may be determined by questionnaire. Outcomes should be expressed in terms of clinically significant changes in symptoms. Follow-up evaluation is required to determine the persistence of changes. At least 2 independent trials should be conducted before a product receives approval.     

Heat pump assisted distillation. VIII: Design of a system for separating ethanol and water

A heat pump assisted distillation system has been designed for the separation of ethanol from 7 per cent aqueous mixtures to produce 93 per cent ethanol by weight. The distillation column has been designed on the basis of conventional design procedures. Valve trays were chosen to provide operational flexibility. R114 was chosen as the working fluid for the mechanical vapour compression heat pump. The heat pump system has been designed to match the heat loads determined for the column. Auxiliary heat exchangers have been provided to aid flexibility and control of column operation.     

Parasite immunology: pathways for expelling intestinal helminths

Helminth parasites induce strong immune responses that are initiated by cytokines, in the first instance interleukin-4 and interleukin-13. Recent studies of knockout mice deficient in these mediators or their shared receptor have revealed discrete pathways required for expulsion of different gut parasites.