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91.
Kodgirwar Vidya P. Deosarkar Shankar B. Joshi Kalyani R. 《Wireless Personal Communications》2020,110(1):423-444
Wireless Personal Communications - Applications of wireless sensor networks (WSNs) are increasing tremendously to facilitate and establish a link between the physical world and information system.... 相似文献
92.
Dr. Yuteng Wu Dr. M. Teresa Bertran James Rowley Dr. Ewen D. D. Calder Dhira Joshi Dr. Louise J. Walport 《ChemMedChem》2021,16(20):3185-3188
The major obstacle in applying peptides to intracellular targets is their low inherent cell permeability. Standard approaches to attach a fluorophore (e. g. FITC, TAMRA) can change the physicochemical properties of the parent peptide and influence their ability to penetrate and localize in cells. We report a label-free strategy for evaluating the cell permeability of cyclic peptide leads. Fluorescent tryptophan analogues 4-cyanotryptophan (4CNW) and β-(1-azulenyl)-L-alanine (AzAla) were incorporated into in vitro translated macrocyclic peptides by initiator reprogramming. We then demonstrate these efficient blue fluorescent emitters are good tools for monitoring peptide penetration into cells. 相似文献
93.
Babu R. Dawadi Danda B. Rawat Shashidhar R. Joshi Pietro Manzoni Martina M. Keitsch 《International Journal of Network Management》2021,31(4):e2145
This paper studies a problem for seamless migration of legacy networks of Internet service providers to a software-defined networking (SDN)-based architecture along with the transition to the full adoption of the Internet protocol version 6 (IPv6) connectivity. Migration of currently running legacy IPv4 networks into such new approaches requires either upgrades or replacement of existing networking devices and technologies that are actively operating. The joint migration to SDN and IPv6 network is considered to be vital in terms of migration cost optimization, skilled human resource management, and other critical factors. In this work, we first present the approaches of SDN and IPv6 migration in service providers' networks. Then, we present the common concerns of IPv6 and SDN migration with joint transition strategies so that the cost associated with joint migration is minimized to lower than that of the individual migration. For the incremental adoption of software-defined IPv6 (SoDIP6) network with optimum migration cost, a greedy algorithm is proposed based on optimal path and the customer priority. Simulation and empirical analysis show that a unified transition planning to SoDIP6 network results in lower migration cost. 相似文献
94.
Bharat Kumar Reddy Sanapalli Shivaramakrishnan Balasubramanian Jawahar Natarajan Uday Krishna Baruah 《Drug development and industrial pharmacy》2018,44(10):1650-1658
5-Aminosalicylic acid (5-ASA) is an aminosalicylate anti-inflammatory drug, which is also known as mesalazine or mesalamine. Currently employed in treating inflammatory bowel disease, ulcerative colitis, inflamed anus or rectum, and maintain remission in Crohn's disease. Evidence from the researchers highlighted its significant re-epithelization in allergic asthma, aphthous, and gastric ulcerative conditions. The objective of the study was to formulate the pluronic lecithin organogel (PLO) containing 5-ASA and evaluate its wound-healing ability in a full thickness excision wound rat model. The data obtained from in silico docking studies revealed 5-ASA is having an affinity towards the transforming growth factor-beta (TGF-β) specifically towards beta1. Among various formulations prepared (F1 to F8), F1, and F6 have shown a maximum in vitro drug release with optimum pH and viscosity. From MTT assay it was found that selected PLO formulations showed no toxicity and enhanced cell proliferation in HaCaT cell lines. In vivo wound-healing studies in albino Wistar rats has revealed that PLO accelerates wound closure and reepithelization to the statistically significant level on day 3 (p?.05) in comparison with untreated wounds. In conclusion, the overall results suggest that 5-ASA PLO gel is a potential therapeutic option for the treatments of wounds, however, further studies are highly warrened to determine the various mechanisms of 5-ASA in regulating the cell migration and reepithelization in wound healing to outspread its use in clinics. 相似文献
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97.
Pramod N. Jagadale Shivaji R. Kulal Meghanath G. Joshi Pramod P. Jagtap Sanjay M. Khetre Sambhaji R. Bamane 《Materials Science-Poland》2013,31(2):269-275
Here we report a successful preparation of nanostructured calcium silicate by wet chemical approach. The synthesized sample was characterized by various physico-chemical methods. Thermal stability was investigated using thermo-gravimetric and differential thermal analysis (TG-DTA). Structural characterization of the sample was carried out by the X-ray diffraction technique (XRD) which confirmed its single phase hexagonal structure. Transmission electron microscopy (TEM) was used to study the nanostructure of the ceramics while homogeneous grain distribution was revealed by scanning electron microscopy studies (SEM). The elemental analysis data obtained from energy dispersive X-ray spectroscopy (EDAX) were in close agreement with the starting composition used for the synthesis. Superhydrophilic nature of CaSiO3 was investigated at room temperature by sessile drop technique. Effect of porous nanosized CaSiO3 on early adhesion and proliferation of human bone marrow mesenchymal stem cells (BMMSCs) and cord blood mesenchymal stem (CBMSCs) cells was measured in vitro. MTT cytotoxicity test and cell adhesion test showed that the material had good biocompatibility and promoted cell viability and cell proliferation. It has been stated that the cell viability and proliferation are significantly affected by time and concentration of CaSiO3. These findings indicate that the CaSiO3 ceramics has good biocompatibility and that it is promising as a biomaterial. 相似文献
98.
Raju Kumar Gupta Bharat Panjwani N. Satyanarayana Sujeet K. Sinha M. P. Srinivasan 《Tribology Letters》2012,45(2):371-378
In this study, we have employed covalent molecular assembly to fabricate robust thin film structures comprising molecular
layers and have demonstrated its application in tribology. An anhydride-functionalized polymer (gantrez) was deposited over
an amine-functionalized silicon surface through covalent binding and employed as an intermediate layer between derivatized
silicon and perfluoropolyether (PFPE). X-ray photoelectron spectroscopy, atomic force microscopy, and ellipsometry were employed
to study the interfacial chemistry, morphology, and thickness of the assembled films. The films show excellent stability and
strength against sonication, which can be attributed to the covalent interlayer linkage. Such films showed wear life of >100,000
cycles in ball-on-disk sliding tests at a normal load of 0.5 N and a sliding rotation of 200 rpm at a track radius of 3.2 mm.
The performance was superior compared to that of PFPE-coated self assembled monolayers used as the lubricating layer. The
film systems and assembly technique can be employed as nano-lubrication in several technological applications, such as information
storage devices and micro-electro-mechanical systems. 相似文献
99.
A Combinatorial Approach for Assessing the Magnetic Properties of High Entropy Alloys: Role of Cr in AlCoxCr1–xFeNi 下载免费PDF全文
100.
S. Kumar V. Vidyasagar A. Jyothirmayi S. V. Joshi 《Journal of Thermal Spray Technology》2016,25(4):745-756
The cold-spray technique is of significant interest to deposit refractory metals with relatively high melting point for a variety of demanding applications. In the present study, mechanical properties of cold-sprayed tantalum coatings heat treated at different temperatures were investigated using microtensile testing, scratch testing, and nanoindentation. The corrosion performance of heat-treated coatings was also evaluated in 1 M KOH solution, and potentiodynamic polarization as well as impedance spectroscopy studies were carried out. Assessment of structure–property correlations was attempted based on microstructure, porosity, and intersplat bonding state, together with mechanical and corrosion properties of the heat-treated cold-sprayed tantalum coatings. Coatings annealed at 1500 °C, which is very close to the recrystallization temperature of tantalum, were found to perform almost as bulk tantalum, with exciting implications for various applications. 相似文献