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排序方式: 共有783条查询结果,搜索用时 171 毫秒
1.
Bharat Kumar Reddy Sanapalli Shivaramakrishnan Balasubramanian Jawahar Natarajan Uday Krishna Baruah 《Drug development and industrial pharmacy》2018,44(10):1650-1658
5-Aminosalicylic acid (5-ASA) is an aminosalicylate anti-inflammatory drug, which is also known as mesalazine or mesalamine. Currently employed in treating inflammatory bowel disease, ulcerative colitis, inflamed anus or rectum, and maintain remission in Crohn's disease. Evidence from the researchers highlighted its significant re-epithelization in allergic asthma, aphthous, and gastric ulcerative conditions. The objective of the study was to formulate the pluronic lecithin organogel (PLO) containing 5-ASA and evaluate its wound-healing ability in a full thickness excision wound rat model. The data obtained from in silico docking studies revealed 5-ASA is having an affinity towards the transforming growth factor-beta (TGF-β) specifically towards beta1. Among various formulations prepared (F1 to F8), F1, and F6 have shown a maximum in vitro drug release with optimum pH and viscosity. From MTT assay it was found that selected PLO formulations showed no toxicity and enhanced cell proliferation in HaCaT cell lines. In vivo wound-healing studies in albino Wistar rats has revealed that PLO accelerates wound closure and reepithelization to the statistically significant level on day 3 (p?.05) in comparison with untreated wounds. In conclusion, the overall results suggest that 5-ASA PLO gel is a potential therapeutic option for the treatments of wounds, however, further studies are highly warrened to determine the various mechanisms of 5-ASA in regulating the cell migration and reepithelization in wound healing to outspread its use in clinics. 相似文献
2.
Flexible materials with balanced dielectric as well as conductive characteristics have elucidated considerable demand in field of research where conventional dielectric or insulators can be replaced by recent advances in various electronics appliances. Our work describes the detailed analyses of dielectric properties like dielectric constant, losses, and electric modulus by means of broadband dielectric spectroscopy over frequency ranging from 0.1 Hz to 10 MHz and temperature ranging from 0 to 60 °C for poly(vinyl alcohol)‐polyaniline (PVA‐PANI) free standing electrospinning nonwoven mat. It has been contemplated that the dielectric constant was enhanced by increasing PANI concentration for complete range of frequency at room temperature. The enhanced dielectric constant value (5.14 at 0.1 Hz, 2.66 at 1 KHz, 2.58 at 10 KHz, and 2.19 at 10 MHz) was anticipated for 7 wt % loading of PANI which was attributed to the presence of dipoles and interfacial polarization enclosed by the polymers. The increased dielectric constant with PANI dosing as well as with temperature attributed to favorable interfacial polarization. Shifting of peak is noticed in the spectra of imaginary electric modulus with increase in temperature which indicates increased chain dynamics of polymers in the mat. Three‐dimensional analysis of the field emission scanning electron microscopy images was carried out by SPIP analytical software. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46121. 相似文献
3.
Dr. Richa Sharma Tulika Srivastava Alka Raj Pandey Dr. Tripti Mishra Dr. Bhagyashri Gupta Dr. Sabbu Sathish Reddy Dr. Suriya P. Singh Dr. Tadigoppula Narender Aradhya Tripathi Dr. Balasubramanian Chandramouli Dr. Koneni V. Sashidhara Dr. Smriti Priya Dr. Niti Kumar 《ChemMedChem》2021,16(13):2146-2156
Defective protein folding and accumulation of misfolded proteins is associated with neurodegenerative, cardiovascular, secretory, and metabolic disorders. Efforts are being made to identify small-molecule modulators or structural-correctors for conformationally destabilized proteins implicated in various protein aggregation diseases. Using a metastable-reporter-based primary screen, we evaluated pharmacological chaperone activity of a diverse class of natural products. We found that a flavonoid glycoside ( C-10 , chrysoeriol-7-O-β-D-glucopyranoside) stabilizes metastable proteins, prevents its aggregation, and remodels the oligomers into protease-sensitive species. Data was corroborated with additional secondary screen with disease-specific pathogenic protein. In vitro and cell-based experiments showed that C-10 inhibits α-synuclein aggregation which is implicated in synucleinopathies-related neurodegeneration. C-10 interferes in its structural transition into β-sheeted fibrils and mitigates α-synuclein aggregation-associated cytotoxic effects. Computational modeling suggests that C-10 binds to unique sites in α-synuclein which may interfere in its aggregation amplification. These findings open an avenue for comprehensive SAR development for flavonoid glycosides as pharmacological chaperones for metastable and aggregation-prone proteins implicated in protein conformational diseases. 相似文献
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Preethi Balasubramanian Teresa Büttner Valentina Miguez Pacheco Aldo R. Boccaccini 《Journal of the European Ceramic Society》2018,38(3):855-869
Boron is considered to influence the performance of several metabolic enzymes and boron deficiency is associated with impaired growth and abnormal bone development. As such, boron is a beneficial bioactive element for animals and humans. It is also well known that boron stimulates wound healing and improves bone health. The addition of boron in different proportions to bioactive glasses has significant effects on glass structure, glass processing parameters, biodegradability, biocompatibility, bioactivity and cytotoxicity. Different compositions of bioactive glasses (BGs) containing boron, including boron-doped, borosilicate and borate glasses, are being investigated for bone and soft tissue engineering under the premise that these BGs are suitable carriers of boron, indicating controlled release of B species in the biological environment. This paper reviews up to date research and applications of borate, borosilicate, and boron doped silicate and phosphate BGs focussing on their physical, structural, degradation and biological properties for hard and soft tissue regeneration. 相似文献
7.
Krishnan Balasubramanian 《Fullerenes, Nanotubes and Carbon Nanostructures》2020,28(9):687-696
AbstractWe have developed combinatorial generation function methods that combine M?bius inversion and character cycle indices for the enumeration of stereo, position and chiral isomers of icosahedral giant fullerenes C180 and C240. Techniques are also developed for the machine perception of symmetries of especially giant fullerenes. The techniques yield, symmetries, position, stereo and chiral isomers of giant fullerenes which we illustrate with applications to icosahedral C180(Ih), and C240(Ih). We have obtained combinatorial tables for the isomers of C180Xk and C240Xk. Our results point to errors in previous computations on C240 permutations. We have also outlined applications to NMR and ESR spectroscopy. 相似文献
8.
Balasubramanian Nagarajan Sylvie Castagne Zhongke Wang H.Y. Zheng Kartikeyan Nadarajan 《International Journal of Material Forming》2017,10(1):109-123
Flexible Pad Laser Shock Forming (FPLSF) is a new microforming process using laser-induced shock pressure and a hyperelastic flexible pad to induce high strain-rate (~105 s?1) plastic deformation on metallic foils to produce 3D microcraters. This paper studies the effect of two significant process parameters of FPLSF, flexible pad material and its thickness, on the deformation characteristics of the metal foils using experiments and finite element analysis. A finite element model is developed to simulate the FPLSF process. The stress-strain distribution across the foil and the flexible pad at different process stages of FPLSF are studied using FE analysis. Flexible pad materials including silicone rubber, polyurethane rubber, and natural rubber with thicknesses ranging between 300 μm and 3000 μm have been investigated in detail. Experimental results highlight that both the hardness and thickness of the flexible pad significantly influence the deformed crater geometry, thickness distribution across the formed crater and surface hardness at the crater surfaces. The experimental results are correlated with the stress-strain distributions from finite element analysis to study the underlying behaviors. 相似文献
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10.
Ummen Sabu G. Logesh Mohammad Rashad Anand Joy M. Balasubramanian 《Ceramics International》2019,45(6):6718-6722
Hydroxyapatite has been synthesized using eggshell membrane as bio-template along with the assistance of microwave heating. Eggshell membrane is infiltrated with calcium and phosphorous precursors before heating it in a domestic microwave oven. Hydroxyapatite formed retained the interwoven hierarchical structure of the eggshell membrane. Structural analysis was performed using X-ray diffraction, and the microstructural features are characterized by scanning electron microscopy. Distinct morphological features were present in microwave processed hydroxyapatite when compared to the conventionally processed one. Transmission electron microscopic investigations and BET surface area analysis were also carried out. 相似文献