Association between Single Nucleotide Polymorphism rs1044925 and the Risk of Coronary Artery Disease and Ischemic Stroke

The present study was performed to clarify the association between the acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) single nucleotide polymorphism (SNP) rs1044925 and the risk of coronary artery disease (CAD) and ischemic stroke (IS) in the Guangxi Han population. Polymerase chain reaction and restriction fragment length polymorphism was performed to determine the genotypes of the ACAT-1 SNP rs1044925 in 1730 unrelated subjects (CAD, 587; IS, 555; and healthy controls; 588). The genotypic and allelic frequencies of rs1044925 were significantly different between the CAD patients and controls (p = 0.015) and borderline different between the IS patients and controls (p = 0.05). The AC/CC genotypes and C allele were associated with a decreased risk of CAD and IS (CAD: p = 0.014 for AC/CC vs. AA, p = 0.022 for C vs. A; IS: p = 0.014 for AC/CC vs. AA; p = 0.017 for C vs. A). The AC/CC genotypes in the healthy controls, but not in CAD or IS patients, were associated with an increased serum high-density lipoprotein cholesterol (HDL-C) concentration. The present study shows that the C allele carriers of ACAT-1 rs1044925 were associated with an increased serum HDL-C level in the healthy controls and decreased risk in CAD and IS patients.     

Necessary and sufficient convergence conditions of the instrumental variable method for identification

The consistency of the instrumental variable method is considered for a system driven by independent identically distributed input signals with zero mean. Necessary and sufficient conditions for convergence are developed with respect to the given model structure. The sufficient and necessary conditions are established for cases with and without data prefiltering. In this paper we extend on existing results such that the requirements on the degree of the instrumental variables can be relaxed. Numerical examples supporting the theoretical results are provided.     

西气东输江都-如东线网络架构的优化

针对西气东输江都-如东线频繁出现网络故障的情况,基于江都-如东线现有网络架构,分析了网络系统存在的不足,对网络架构进行了优化,重新划分了局域网,处理了网络环网,禁用了路由器的多余广播,进行了风暴控制,优化了ESD系统参数,提出了在江都-如东线进行网络架构优化的方案。通过对思科交换机、思科路由器、SIXNET交换机和ESD系统的配置进行修改,以及为期1年的试运行,实现了网络故障零发生的目标,提高了网络通讯的质量,保证了系统的可靠性和安全性。     

4G环境下集中化业务支撑系统建设探讨

自4G商用以来,各运营商的4G发展遇到诸多挑战。在业务运营支撑方面,电信运营商原有的两级架构属于分散管理,全网业务难以快速推向市场,集中化运营缺乏有效支撑。本文从4G集中化建设目标出发,结合现有两级支撑架构,分析比对了四种集中化业务支撑思路并给出选择建议,对今后电信运营商集中化支撑系统建设具有一定的启发作用。     

Typoselectivity of Crude Geobacillus sp. T1 Lipase Fused with a Cellulose-Binding Domain and Its Use in the Synthesis of Structured Lipids

Typoselectivity of crude CBD-T1 lipase (Geobacillus sp. T1 lipase fused with a cellulose binding domain) was investigated. Multi-competitive reaction mixtures including a set of n-chain fatty acids (C8:0, C10:0, C12:0, C14:0, C18:1 n-9, C18:2 n-6 and C18:3 n-3) and tripalmitin-enriched triacylglycerols were studied in hexane. The crude CBD-T1 lipase discriminated strongly against C18:1 n-9 [competitive factor (α) = 0.23] and showed the highest preference for C8:0 (α = 1). Utilizing the catalytic properties of crude CBD-T1 lipase, acidolysis of soybean oil with C8:0 was selected as a model reaction to investigate the ability of the lipase to produce MLM-type (medium-long-medium) structured lipids. Several reaction parameters (added water amount, reaction temperature, substrate molar ratio and reaction time) examined for incorporating C8:0 into soybean oil, the optimum conditions were: 1:3 (soybean oil/C8:0) of molar ratio, 3 mL of hexane, 50 °C of temperature, 48 h of reaction time, 20 % of crude CBD-T1 lipase (w/w total substrates), and 7.5 % of water (w/w enzyme). Under these conditions, the incorporation of C8:0 was 29.6 mol%. The results suggest that crude CBD-T1 lipase, which showed different fatty acid specificity profiles, is a potential biocatalyst for the modification of fats and oils.     

某引水工程末端水池裂缝分析及处理措施

钢筋混凝土水池由于各种原因都会使水池产生裂缝,通过从工程设计方面、原材料方面及工程施工方面对某引水工程末端水池裂缝产生的原因进行了方析,并针对本工程的裂缝情况提出了合理化的处理措施。     

Web应用软件测试模型的研究和构建

随着Web应用软件的快速发展，作为保证Web质量和可靠性的重要手段，Web应用软件测试受到了人们越来越多的重视。本文对现有的一些典型web测试思想、技术和工具进行了一定的研究，首先描述了Web应用软件的特点，然后分析和比较了几种测试模型、策略和方法，最后提出了一种基于petri网的Web链接模型。     

多视点中不一致性的处理：一种基于认知逻辑的方法

衡量一个软件系统是否成功,一个基本的要素就是看该软件系统是否满足了用户的要求。软件系统需求工程(RE)就是一个通过标识涉众及其需求并将其文档化以便于进行分析的过程。RE是一个跨学科,以人为中心的过程。多视点需求工程是需求工程的一个分支。多视点需求工程就是希望复杂系统中的不同参与者分别从自己的角度出发对预期系统进行描述,从而形成更完备的需求规约。由于多视点方法的这种特性,导致多个涉众有可能对同一问题进行描述,从而形成重叠的需求。这些重叠的需求就是涉众之间的公共知识,对公共知识的不同解释是导致需求规约中不一致问题的根源。不一致性是多视点需求工程中一个必须解决的问题。本文提出了基于问题域的多视点需求建模框架,并利用认知逻辑对该框架进行解释和推理,希望可以用形式化的方法来发现和解决存在于不同视点间的不一致性。     

辅导学生报考报关员资格的实践

本通过对全国报关员统一考试多方面分析，提出在辅导学生中所使用的教学策略以及教学计划的建议，从而指导学生顺利通过全国报关员统一考试。