纳米药物非临床药代动力学的研究策略及关注要点

随着纳米技术的迅速发展，纳米药物的研发已成为目前药物创新的发展方向之一。纳米药物具有基于纳米结构的尺度效应，其药代动力学特征与普通药物相比存在明显差异，其药代动力学研究与普通药物相比也有其特殊性。本文着重探讨纳米药物的非临床药代动力学的研究策略及关注要点，包括受试物、体内/外试验、生物样本分析、数据评价分析等，期望为研发者提供参考。     

IP网络信源信道联合编码策略

面向IP网络,讨论了一种信源编码的失真估计模型,并用典型的视频编码器作了验证.提出了一种基于包的信道编码方法,并将该方法引入信道编码的失真估计中,对一种信道编码的失真估计模型作了改进.以前述内容为基础,提出了两种信源信道联合编码策略,实验结果表明,这两种策略得到的最优结果在很大程度上提高了视频重建质量.     

Effect of Pressure Gradient on Heat Transfer of Impinging Submerged Circular Jets

An experimental and numerical study have been carried out to investigate the distribution of radial local heat transfer coefficients of impinging submerged circular jets. Good agreement is achieved between the experimental results and the predicted value. Results show that the outer peak usually occurs at the radial location of r/d= 1.8~2.0, in which transition from laminar to turbulence happens resulting from disappeared pressure gradient abruptly, and that the inner peak appears rigidly at r/d=0.5, where the boundary layer has a minimum thickness because of elevating pressure gradient.     

Dye-sensitized solar cell based on nanocrystalline TiO<Subscript>2</Subscript> with 3–10 nm in diameter

Nanocrystalline TiO₂ with 3–10 nm in diameter was prepared with a surfactant-template method. Dye-sensitized solar cells were assembled using the prepared nanocrystalline TiO₂ with large surface area and high crystallinity, which achieved significant higher Jsc when compared to cells fabricated with bigger particles of 25 nm in diameter. In the cells with nanocrystalline TiO₂, the sintering temperature drastically affected the conversion performance of the cells.     

对完善公司物资供应管理体系的思考

针对经“债转股”和资产重组成立的北京东方石油化工有限公司物资供应管理特点和存在的问题，从供应管理模式、采购方式、采购过程监控、信息化管理、物资储备、人员结构等6个方面，分析了目前供应管理存在的问题和不足，并针对问题通过对物资供应管理体制的分析和思考，提出对策，为新的物资供应体制的建立提供参考。     

Fuzzy control of nitrogen removal in predenitrification process using ORP.

In order to meet increasingly stringent discharge standards, new applications and control strategies for the sustainable removal of nitrogen from wastewater have to be implemented. In the past years, numerous studies have been carried out dealing with the application of fuzzy logic to improve the control of the activated sludge process. In this paper, fuzzy control strategies of predenitrification systems are presented that could lead to better effluent quality and, in parallel, to a reduction of chemicals consumption. Extensive experimental investigations on lab scale plant studies have shown that there was excellent correlation between nitrate concentration and ORP value at the end of the anoxic zone. Results indicated that ORP could be used as an on-line fuzzy control parameter of nitrate recirculation and external carbon addition. The optimal value of ORP to control nitrate recirculation and external carbon addition was - 86 +/- 2 mV and - 90 +/- 2 mV, respectively. The results obtained with real wastewater also showed the good performance and stability of the fuzzy controllers independently from external disturbances. The integrated control structure of nitrate recirculation and external carbon addition in the predenitrification system is also presented.     

Field emission mechanism from nanocrystalline cubic boron nitride films

An electron-emission theoretical model integrating the change in the grain size of nanocrystalline cubic boron nitride (c-BN) thin films was established. To understand better the essence of field emission, an accurate numerical scheme, the transfer matrix method, that can be used to compute the tunneling coefficients of the actual surface barrier, was also adopted. The present results show that the emission current from nanocrystalline grain films is far larger than that from regular grain films or bulk c-BN.     

地面无线三维定位系统

本文介绍了一种地面无线三维定位系统,说明了其结构、功能、硬件、软件及其实现。采用信息广播机制的无线三维定位方法,实现独立网络支持下的具有分层结构的建筑区域中的移动人员的无线三维定位,可应用于大型、中型、小型等各类系统中。     

电力工程企业引入第三方质量巡查机制的探讨

国内电力工程项目质量管理普遍存在项目多、资源少、监管难、风险大等问题,往往不能及时发现质量隐患、预防质量事故。文章立足于电力工程企业,从加强电力工程项目质量监管入手,比较传统质量巡查和第三方质量巡查两种模式,阐述引入第三方质量巡查机制的操作流程及注意事项,并结合实例分析第三方质量巡查机制的应用效果和在电力工程企业质量管理中的推广价值。     

以对标国际促进电力企业高质量发展

随着“一带一路”建设的推进,我国电力企业紧抓机遇,以市场为导向,以项目为依托,积极开拓海外市场,开展跨国经营,在更大范围、更广领域、更高层次上参与国际电力市场的开发合作与竞争。然而,在全球市场上,我国电力企业的国际化经营水平却处于较低水平。在走向国际化同时,需结合自身实际,从管理、技术上有所创新,步步为营,吸收国外先进的技术与管理经验,注重企业文化的形成,而国际对标则是提高企业国际竞争力的重要途径,是企业迈向国际尖端水平的“快捷方式”。