吡唑醚菌酯悬浮剂的研制及配方中表面活性剂的复配性能分析

[目的]开发吡唑醚菌酯悬浮剂,并对较优配方中表面活性剂复配性能进行研究。[方法]采用湿法研磨工艺,通过粒径及稳定性等指标的测试,对配方中的润湿分散剂、增稠剂和防冻剂等进行了筛选,并采用表面张力法对表面活性剂组合的复配性能进行了研究。[结果]当表面活性剂8561与G5000的用量为5%和1%时,即摩尔比为4:1时,可制得合格的15%和25%吡唑醚菌酯悬浮剂。在该比例下,2种表面活性剂具有强烈的相互作用,与宏观现象相符。[结论]将复配表面活性剂协同增效理论与农药悬浮剂的研制相结合,对农药制剂研究工作有一定的指导意义。     

SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure

Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured by oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whether the novel compound SUL-151 with mitoprotective properties can be used as a prophylactic and therapeutic treatment in a murine CS-induced inflammation model. SUL-151 (4 mg/kg), budesonide (500 μg/kg), or vehicle were administered via oropharyngeal instillation in this prophylactic and therapeutic treatment setting. The number of immune cells was determined in the bronchoalveolar lavage fluid (BALF). Oxidative stress response, mitochondrial adenosine triphosphate (ATP) production, and mitophagy-related proteins were measured in lung homogenates. SUL-151 significantly decreased more than 70% and 50% of CS-induced neutrophils in BALF after prophylactic and therapeutic administration, while budesonide showed no significant reduction in neutrophils. Moreover, SUL-151 prevented the CS-induced decrease in ATP and mitochondrial mtDNA and an increase in putative protein kinase 1 expression in the lung homogenates. The concentration of SUL-151 was significantly correlated with malondialdehyde level and radical scavenging activity in the lungs. SUL-151 inhibited the increased pulmonary inflammation and mitochondrial dysfunction in this CS-induced inflammation model, which implied that SUL-151 might be a promising candidate for COPD treatment.     

一种高压断路器伺服控制器设计方案

为进一步提升高压断路器智能化水平,在高压断路器电机直驱机构研究的基础上,分析了永磁体尺寸对电机性能的影响,设计了电机直驱高压断路器伺服控制系统。其伺服控制器硬件系统包含功率变换模块、转子位置检测模块、电压及电流采样模块以及通信模块等,同时,基于此硬件系统设计实现了各模块之间的信息交互以及系统控制的软件系统。搭建伺服控制器与高压断路器电机直驱机构的试验样机,进行高压断路器的分、合闸操作特性测试。试验结果表明：所提出的高压断路器伺服控制器设计方案可以驱动断路器动触头根据设定曲线完成分、合闸操作,具有响应速度快、实时性能好、跟踪误差小等优点,同时可以实现操作过程数据的存储及通信。     

Synthesis and XPS investigation of superdense lithium-graphite intercalation compound, LiC2

The superdense lithium-graphite intercalation compound (GIC),LiC₂, first synthesized by the author was prepared by the original technique in a piston-cylinder high-pressure chamber with internal heater. Cleaved surfaces of this compound, LiC₃, LiC₆ and pristine graphite were studied by the X-ray photoelectron spectroscopy (XPS) technique. It was shown that chemical shifts of carbon do not vary in the range LiC₆ to LiC₂ which suggests that the additional lithium intercalation into LiC₆ gives no significant change in the charge transfer rate per carbon atom. Carbon/lithium atom ratios were obtained for freshly cleaved surfaces and for the surfaces after argon ion bombardment. It was shown that the bombardment results in the surface decomposition of LiC₂-GIC.     

复合变质处理对铸造热锻模具钢力学性能的影响

研究了变质处理对铸造热锻模具钢力学性能的影响。结果表明：在相同热处理条件下，经RE和RE—Nb复合变质处理后，其冲击韧性与变质处理前相比分别提高了9．7和14．5J／cm^2，常温抗拉强度σb分别提高了82和234MPa，高温抗拉强度分别达到了976和994MPa，而硬度变化不大。     

MICROSTRUCTURE OF RAPIDLY SOLIDIFIED TiAl ALLOY POWDER

The rapidly solidified powder of Ti-34Al-2Mn alloy was obtained by means of ultrasonicgas atomisation (USGA) technique.The tupical size of the powder is 27 μm.X-ray diffractionresults show that the powder consists of major α_2-phase and minor γ-phase.Under opticalmicroscope both equiaxed and dendritical microstructure features were observed on RS pow-der sections.After annealing at 900 ℃/for 2 h in vacuum,most of α_2-phase transforms intoγ-phase,resulting in refinement of structure.     

BEHAVIOR OF Mg AND ITS EFFECT ON MECHANICAL PROPERTIES OF CAST Fe_3Al ALLOYS

Proper addition of 0.002 wt-% Mg to cast Fe_3Al alloy may obviously improve the room andhigh temperature tensile properties.Auger spectra show that Mg segregates near grainboundaries as very thin layers.Observation under TEM reveals that a suitable amount of Mgenhances ability of cooperative internal deformation so that the dislocations will ease the con-tinuous slip deformation through grain boundaries.The fracture feature of Fe_3Al alloy is oftransgranular cleavage at room temperature and cracks initiate at grain boundaries.     

硼对快凝Ni3Al组织结构及力学性能的影响

本文通过快凝及加硼合金化的方法改善金属间化合物Ni_3Al的韧性。实验表明:加入0.5-1.4at.-％的硼对Ni_3Al的塑性提高最有利。结构分析表明:在含1.37at.-％硼的Ni_3Al中,硼以Ni_(23)B_6弥散相及晶界偏聚方式存在;当硼量增至2.22at.-％时,硼以粗大的Ni_(23)B_6及NiB_(12)相在晶界处析出。无硼的Ni_3Al晶界为大角度晶界;当硼加至1.37at.-％时,Ni_3Al晶界以位错排列成亚晶界,以小角晶界形式存在。     

添加Ce与P+Sr复合变质对高硅耐热铝合金组织与性能的影响

研究了添加Ce与P＋Sr复合变质对Al-21Si-1.5Cu-0.5Mg-2.5Fe合金显微组织与性能的影响.结果表明：添加1.5?使粗大针状铁相消失,形成富Ce富Fe的鱼骨状相;P＋Sr复合变质可使初晶硅平均尺寸由70mm细化到20mm,共晶硅平均截线长降到2.1 mm,合金室温抗拉强度比未变质前提高21.5%,与P＋Sr＋Ce复合变质的Al-21Si-1.5 Cu-1.5Ni-2.5Fe-0.5Mg合金相当.     

化合物TbMn6Sn6的磁性和磁相变

采用分子场理论模型对稀土-过渡族金属间化合物的磁性、自旋重取向相变和场诱导的一级磁相变进行了研究.从理论上计算了TbMn6Sn6的易磁化方向随温度的变化以及不同温度时的磁化曲线,描述了自旋重取向相变和场诱导的一级磁相变.基于单离子模型计算了Tb离子和化合物的一阶和二阶磁晶各向异性常数及其随温度的变化,得到了和实验数据基本一致的结果.结果表明:Mn次晶格和Tb次晶格磁晶各向异性能之间的相互竞争是导致自旋重取向相变的物理机制,而稀土离子的四阶晶场项对场诱导的一级磁相变产生很大的影响.