附加在车床上的疲劳裂纹装置

本文介绍一种作者自己设计的疲劳裂纹装置．它可以代替价格昂贵的高频疲劳试验机；用于对三点弯曲试件预制疲劳裂纹．该装置结构简单，容易制造．投资少，附加在车床上即可工作．     

球状碳单质分子的发现,研究现状及应用前景

综述了碳的第三种同素异形体──球状碳单质分子的发现、结构、性质及其应用前景。     

A singular loop transformation framework based on non-singular matrices

In this paper, we discuss a loop transformation framework that is based on integer non-singular matrices. The transformations included in this framework are called Λ-transformations and include permutation, skewing and reversal, as well as a transformation calledloop scaling. This framework is more general than existing ones; however, it is also more difficult to generate code in our framework. This paper shows how integer lattice theory can be used to generate efficient code. An added advantage of our framework over existing ones is that there is a simple completion algorithm which, given a partial transformation matrix, produces a full transformation matrix that satisfies all dependences. This completion procedure has applications in parallelization and in the generation of code for NUMA machines. This work was supported by the Cornell Theory Center, NSF Presidential Young Investigator award #CCR-8958543. by NSF Grant #CCR-9008526, and by a grant from the Hewlett-Packard Company.     

基于交流比例积分控制器的单相逆变器

提出一种电感电流、输出电压瞬时值反馈控制和负载电流前馈控制相结合的复合控制策略。在此基础上,研制了一台800W的单相逆变器。实验结果表明,提出的控制策略改善了逆变器输出电压的波形,提高了系统的暂态特性。     

A new intelligent prediction system model-the compound pyramid model

A current development trend in research on intelligent systems is to optimize a general intelligent prediction system into an individuation intelligent prediction system that is applied in specialized fields. Protein structure prediction is a challenging international issue. In this paper, we propose a new intelligent prediction system model, designed as a multi-layer compound pyramid model, for predicting secondary protein structure. The model comprises four independent intelligent interfaces and several knowledge discovery methods. The model penetrates throughout the domain knowledge, with the effective attributes chosen by Causal Cellular Automata. Furthermore, a high pure structure database is constructed for training. On the RS126 dataset, the overall state per-residue accuracy, Q3, reached 83.99%, while on the CB513 dataset, Q3 reached 85.58%. Meanwhile, on the CASP8 sequences, the results are superior to those produced by other methods, such as Psipred, Jpred, APSSP2 and BehairPred. These results confirm that our method has a strong generalization ability, and that it provides a model for the construction of other intelligent systems.     

Novel technology of purification of copper electrolyte

The effects of arsenic with different valence states on the purification of copper electrolyte were studied and a novel technology of purification of copper electrolyte by copper arsenite was proposed. The results show that the purification performance of As（Ⅲ） compounds is better than that of As（Ⅴ） compounds. The purification technology by copper arsenite has the advantages of simple operation, high purification performance and low cost in comparison with other technologies and its appropriate purification conditions are that copper arsenite concentration is 18 g/L, reaction temperature is 65 ℃ and reaction time is 8 h. The removal rates of Sb and Bi are 53.22% and 58.67% respectively under these conditions. The purification principle show that a kind of yellow precipitate mainly composed of arsenic, antimony （ Ⅴ ）, bismuth and oxygen forms in electrolyte after copper arsenite is added, and consequently antimony and bismuth are removed from electrolyte.     

COLLMANN2824轮胎检测X光机U形探测器及硬件升级

轮胎X射线检测机随着使用年限的增加,故障会逐步增多,维护费用和维护难度也在增长,特别是设备最核心的成像系统会出现电路板和传感器老化现象,使轮胎X射线图像出现模糊、区域过亮或过暗、黑条或白条(传感器整块宽度图像丢失)、竖线(传感器像素宽度图像丢失)等故障,导致检测效果变差甚至会出现检测盲区,最终出现漏检现象。     

一种雪地轮胎的结构设计

本文介绍了265/70R17115S规格雪地轮胎的设计,外轮廓方面,轮胎的设计外直径797 mm,充气断面宽282 mm,轮胎的行驶面宽207 mm,设计行驶面弧高度8.5 mm,胎圈着合直径取值430 mm,轮胎的胎圈着合宽度237.8 mm,轮胎的断面水平轴位置取值0.96746;轮胎的胎面花纹设计分为长型花纹(M型、L型)与短型花纹(S型),3种花纹为交替变节距呈现,花纹深度10.4 mm,花纹饱和度68.16%。轮胎的施工设计方面:胎面挤出部件为全分层设计,可更好的区分胶种,功能性更强,胎侧挤出部件为双复合设计,冠带层的1#、2#带束层材料使用3×0.30HT钢丝帘线,胎圈部位的钢丝圈为斜六角形结构,更好的保证了成品断面钢丝圈部位,切割后呈近圆形;胎胚成型使用的设备是萨驰一次法成型机,胎胚硫化使用的设备是韩国东和液压硫化机,硫化工艺为氮气硫化。生产的成品轮胎的外缘尺寸、强度性能和耐久性能等均满足国家标准要求。     

Identification of Cyclophilin A as a Potential Anticancer Target of Novel Nargenicin A1 Analog in AGS Gastric Cancer Cells

We recently discovered a novel nargenicin A1 analog, 23-demethyl 8,13-deoxynargenicin (compound 9), with potential anti-cancer and anti-angiogenic activities against human gastric adenocarcinoma (AGS) cells. To identify the key molecular targets of compound 9, that are responsible for its biological activities, the changes in proteome expression in AGS cells following compound 9 treatment were analyzed using two-dimensional gel electrophoresis (2-DE), followed by MALDI/TOF/MS. Analyses using chemical proteomics and western blotting revealed that compound 9 treatment significantly suppressed the expression of cyclophilin A (CypA), a member of the immunophilin family. Furthermore, compound 9 downregulated CD147-mediated mitogen-activated protein kinase (MAPK) signaling pathway, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) by inhibiting the expression of CD147, the cellular receptor of CypA. Notably, the responses of AGS cells to CypA knockdown were significantly correlated with the anticancer and antiangiogenic effects of compound 9. CypA siRNAs reduced the expression of CD147 and phosphorylation of JNK and ERK1/2. In addition, the suppressive effects of CypA siRNAs on proliferation, migration, invasion, and angiogenesis induction of AGS cells were associated with G2/M cell cycle arrest, caspase-mediated apoptosis, inhibition of MMP-9 and MMP-2 expression, inactivation of PI3K/AKT/mTOR pathway, and inhibition of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) expression. The specific interaction between compound 9 and CypA was also confirmed using the drug affinity responsive target stability (DARTS) and cellular thermal shift assay (CETSA) approaches. Moreover, in silico docking analysis revealed that the structure of compound 9 was a good fit for the cyclosporin A binding cavity of CypA. Collectively, these findings provide a novel molecular basis for compound 9-mediated suppression of gastric cancer progression through the targeting of CypA.     

木质素单体模化物的热解与产物分析

采用苯酚、邻苯二酚、愈创木酚和紫丁香酚为木质素单体模化物,利用两段裂解反应器-在线气相色谱仪（GCs）进行热解实验和产物分析,采用多色谱柱对无机气体（IGs）、C₁~C₅烃（C₁~C₅ LHs）、非芳基含氧化合物、酚和芳烃进行定量分析,以确定羟基和甲氧基对木质素热解过程中开环反应及产物分布的影响. 结果显示：羟基和甲氧基可以提高模化物的转化率,且羟基和甲氧基的存在影响芳基开环反应、芳基取代反应和重排反应间的竞争关系,使热解产物分布存在明显差异. 4种模化物热解产物主要是芳环的开环反应产物,包括IGs（质量分数为27.29%~33.56%）和C₁~C₅烃（20.46%~39.51%）. 一氧化碳产率（23.82%~29.18%）随羟基数增加而升高,随甲氧基数增加而降低;二氧化碳产率（0.19%~9.61%）随甲氧基数增加而升高. 羟基和甲氧基的存在降低了C₁~C₅烃的质量选择性,促进了烷基苯、大分子化合物和焦炭的形成.