韶钢信息化建设之实践

韶钢的信息化建设主要经历了三个阶段：初步开发、规模开发、协同应用，同步实施ERP与MES，实现产销一体化、财务业务一体化、管理控制一体化．     

现代制造执行系统--管控一体化的关键

针对管控一体化系统的需求，首先，本文给出了管控一体化系统的结构，作为其中心环节，制造执行系统(Manufac-turing Execution System，MES)是管控一体化系统信息集成和实现的关键。进而基于流程工业特点对MES的体系结构和功能模块进行了探讨，并分析了相应的关键技术。     

基于MES/MRPⅡ生产成本管理系统的设计与实现

成本管理是企业管理的重要组成部分。讨论了基于MRPⅡ和制造执行系统(MES)成本管理系统，该系统可与车间管理其它子系统实现信息集成，同时给出了系统功能模型和实现流程。该系统在实际应用中取得了较好的经济效益和社会效益。     

可集成制造执行系统(I-MES)冲突消解研究

首先构造了基于多Agent的I—MES体系结构，并针对I—MES中最常见的资源冲突问题，建立了多Agent合作的冲突消解模型，同时将PERT／CPM方法引入到I—MES系统的冲突消解过程，对所发生的冲突进行分类，并以非关键路径冲突为例，讨论多代理合作的冲突消解策略，并给出基于KQML—BDI的协商协议。最后开发了该原型系统，以验证冲突消解策略和协商协议。     

钢铁企业先进生产计划和实时生产调度技术的研究

为了解决钢铁企业目前由于缺乏生产计划和调度系统而造成的宏观调控和实时监控等方面存在的问题，在对现有钢铁企业的信息化体系结构和生产管理模式等进行理论研究的基础上，提出了基于MRP II与JIT相结合的特钢行业生产管理模式；采用多层递阶计划和动态实时调度策略，构建面向企业上层管理ERP和下层执行MES系统的集成化解决方案。实现了企业生产计划和调度的整体优化，建立了适合特钢企业经营管理与生产制造一体化的信息系统。     

基于单件小批企业的制造执行系统研究及优化

作为连接企业上层生产计划管理系统和底层设备控制系统之间接口的制造执行系统,是当前管理信息系统研究和开发的热点与难点。本文探讨了适用于单件小批量生产的重型机械制造企业的制造执行系统的结构框架,详细地描述了其各个功能模块的作用,并给出了实现系统优化调度的遗传算法的问题编码、遗传操作和评价函数以及算法的整个过程。按照这种框架所构建的制造执行系统,能够实现生产作业计划的实时调度以及生产过程的实时控制。     

制造执行系统实施方实施能力综合评价技术研究

制造执行系统（MES）在制造企业信息化体系中处于重要地位，因而日益受到学术界与工业界的广泛重视。有关其实施方法论的研究，始终是该领域的热点。本文的研究对象是MES实施方实施能力的综合评价体系。首先给出综合评价体系框架，然后提出了多层次全方位的评价指标体系，并应用层次分析法（AHP）和模糊综合评价理论形成了完整的评价方法，最后给出了应用实例。     

MES的计划、调度集成问题研究

在分析制造执行系统(Manufacturing Executive System(MES))产生的背景、概念及其特点的基础上，构造了先进制造车间(Advanced Manufacturing Shopfloor(AMS))计划调度问题的集成功能模型。结合此模型，建立了AMS的作业分批与计划调度的数学模型，并在最后给出了求解此类问题的常用算法。     

Enhanced methane fermentation of municipal sewage sludge by microbial electrochemical systems integrated with anaerobic digestion

Sewage sludge from a municipal wastewater treatment plant was fed into a microbial electrochemical system, combined with an anaerobic digester (MES-AD), for enhanced methane production and sludge stabilization. The effect of thermally pretreating the sewage sludge on MES-AD performance was investigated. These results were compared to those obtained from control operations, in which the sludge was not pretreated or MES integration was absent. The soluble chemical oxygen demand (SCOD) in the raw sewage sludge after pretreatment was 31% higher than the SCOD in untreated sludge (5804.85 mg/L vs. 4441.46 mg/mL). The methane yield and proportion of methane in biogas generated by the MES-AD were higher than those of the control systems, regardless of the pretreatment process. The maximum methane yield (0.28 L CH₄/g COD) and methane production (1139 mL) were obtained with the MES inoculated with pretreated sewage sludge. Methane yield and production with this system using pretreated sewage were 47% and 56% higher, respectively, than those of the control (0.19 L CH₄/g COD, 730 mL). Additionally, the maximum SCOD removal (89%) and current generation were obtained with the MES inoculated with a pretreated substrate. These results suggested that sewage sludge could be efficiently stabilized with enhanced methane production by synergistic combination of MES-AD system with pretreatment process.     

The methionine precursor dl-2-hydroxy-(4-methylthio)butanoic acid protects intestinal epithelial barrier function

dl-2-hydroxy-(4-methylthio)butanoic acid (HMTBA) is a source of dietary methionine (Met) that is widely used in poultry nutrition. We have previously shown that HMTBA is preferentially diverted to the transsulfuration pathway, which gives antioxidant metabolites such as taurine and glutathione. Therefore, here we hypothesize that this Met source can protect epithelial barrier function in an in vitro model of intestinal inflammation of Caco-2 cells. The results show that HMTBA prevents the increase in paracellular permeability induced by H₂O₂ or tumour necrosis factor-α. This effect can be attributed to the increased production of taurine and reduced glutathione. Similar results were obtained for dl-Met, although the protective role of the amino acid was less pronounced than that of the hydroxy analogue. In conclusion, the diversion to the transsulfuration pathway means that this Met precursor is of greater value than previously thought, due to its capacity to improve intestinal homeostasis and the quality of poultry products destined for human consumption.