Bioactive Ca-P scaffolds used for bone reconstruction

1　INTRODUCTIONSkeletalreconstructionorregenerationisre quiredincasesinvolvinglargedefectscreatedbytu morresection ,trauma ,andskeletalabnormalities .Graftsandflapsofautogenoustissuearetwoofthemostsuccessfulmeansofreconstructionbecausetheyallowthetransplantationofbonecontainingbioactivemolecules,livecells ,andfrequently ,avascularsup plythatallowthetransplanttosurviveandremodeleveninhostileradiatedenvironments .However ,onlyaminimalamountoftissuecanbeharvestedforauto grafts,anditisverydiff…     

Thermodynamics of Fe-Cu alloys as described by a classic potential

The Fe-Cu system is of relevance to the nuclear industry because of the deleterious consequences of Cu precipitates in the mechanical properties of Fe. Several sets of classical potentials are used in molecular dynamics simulations studies of this system, in particular that proposed by Ludwig et al. [M. Ludwig, D. Farkas, D. Pedraza, S. Schmauder, Model. Simul. Mater. Sci. Eng. 6 (1998) 19]. In this work we extract thermodynamic information from this interatomic potential. We obtain equilibrium phase diagram and find a reasonable agreement with the experimental phases in the regions of relevance to radiation damage studies. We compare the results with the predicted phase diagram based on other potential, as calculated in previous work. We discuss the disagreements found between the phase diagram calculated here and experimental results, focusing on the pure components and discuss the applicability of these potentials. Improved potentials, primarily for the pure components, should be developed to account for proper phase stability in the solid phase up to melting. Finally we suggest an approach to improve existing potentials for this system.     

Identifying a putative common binding site shared by substance P receptor and an anti-substance P monoclonal antibody

Substance P G-protein coupled receptor and the antigen recognitionsite of a monoclonal antibody raised against substance P sharea stretch of five contiguous identical amino acids. This observationprompted us to build an atomic model of both the receptor andthe antibody and to analyse their common features. In particular,we report here that a pocket of similar size and compositionis present in both proteins, strongly suggesting a similarityin the mode of binding of both macromolecules to substance P.From the analysis of our models, the available data on the modeof binding of the antibody to substance P and recent data onsubstance P receptor mutants, we concluded that the pocket isvery likely to be involved in binding of the C-terminal 'messagesequence' of the tachykinin. This allowed us to suggest specificsite-directed mutants of the receptor which should shed somelight on the mechanism of peptide recognition by G-protein coupledreceptors.     

元数据在P2P网络下查询改进中的应用

针对P2P网络中由于查询条件的弱语义和粗粒度、检索效率低下以及网络带宽消耗的问题提出了一个基于元数据的高效查询算法,通过在任意P2P数据管理层的基础上建立一个统一的元数据层,各个节点自动抽取共享数据的详细的元数据信息,每个节点不仅保存本地共享数据的元数据信息,而且存储访问过的最感兴趣的数据的元数据信息,并使用数据库对元数据信息进行高效管理,从而使所有节点都具有自我学习的能力,充分利用元数据信息提高检索效率。     

对等网络的仿真研究

P2P网络和P2P相关技术一直是计算机网络研究的一大热点。P2P网络具有大规模、高动态性的特点,这使得在真实环境中实际运行、测试一个它需要付出巨大的努力和昂贵的开销。而P2P模拟器具有的优势能为P2P网络研究带来很大的方便,研究者们只需要将精力集中于想要关注的性能,丽不必花费大量的时间和精力去编写实验工具。文中深入研究了PeerSim模拟平台上模拟P2P环境的构建方法,并在其上实现了一个简单的负载平衡算法。最后,通过实验来说明PeerSim模拟器的使用方法,展示了PeerSim组件化的构造思想和灵活的配置机制。     

兴趣和蚁群相结合的非结构化P2P搜索算法

针对传统flooding搜索算法面临的效率低下和网络流量过大等问题,提出了一种改进的基于兴趣和蚁群相结合的资源搜索算法（IASA）。该算法将TTL机制加以改进,并将兴趣相似度引入到蚁群算法的路径概率选择中,同时结合信息素的多样性和正反馈机制,积累历史搜索经验,获得路由指引信息,从而有效地指导查询请求消息的转发,将请求消息尽量发往资源可能存在的节点上。仿真实验表明：该算法能有效地指导资源搜索的方向,提高查询命中率,减少冗余消息包,其整体搜索效果较好。     

基于可编程协议无关报文处理的分布式拒绝服务攻击检测

传统软件定义网络（SDN）中的分布式拒绝服务（DDoS）攻击检测方法需要控制平面与数据平面进行频繁通信,这会导致显著的开销和延迟,而目前可编程数据平面由于语法无法实现复杂检测算法,难以保证较高检测效率。针对上述问题,提出了一种基于可编程协议无关报文处理（P4）可编程数据平面的DDoS攻击检测方法。首先,利用基于P4改进的信息熵进行初检,判断是否有可疑流量发生;然后再利用P4提取特征只需微秒级时长的优势,提取可疑流量的六元组特征导入数据标准化—深度神经网络（data standardization-deep neural network,DS-DNN）复检模块,判断其是否为DDoS攻击流量;最后,模拟真实环境对该方法的各项评估指标进行测试。实验结果表明,该方法能够较好地检测SDN环境下的DDoS攻击,在保证较高检测率与准确率的同时,有效降低了误报率,并将检测时长缩短至毫秒级别。     

基于SkypeP2P混合模式网络的流量控制技术的研究

Skype是一款基于新一代P2P通讯技术的全球性互联网通讯软件,它通过互联网在全世界范围内向客户提供免费的高质量通话服务,Skype使用了P2P协议混合技术,这是P2P技术发展演化过程的新形式,它结合了集中式和分布式的特点,在网络的周边节点采用集中式,在超级节点之间采用分布式。文章重点通过对Skype混合P2P网络机制的研究,提出了一种针对Skype通讯网络流控阻断的实现方法。     

基于P2P的云计算模型及其安全性分析

文章通过将P2P技术和云计算相结合,提出了一种可靠的、可扩展的、低成本的文件共享模型PA-Cloud。该文介绍了PA-Cloud的文件下载和更新过程,并对系统的安全性进行了分析。通过对PA-Cloud进行对比实验表明,PA-Cloud可以有效提高系统的可扩展性,降低服务提供商的成本。