Development and in vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone-ethylcellulose matrices

To select a suitable formulation for the development of transdermal drug-delivery system of diltiazem hydrochloride. Transdermal patches of the drug, employing different ratios of polymers, ethylcellulose (EC), and povidone (PVP) were developed and evaluated for the potential drug delivery using depilated freshly excised abdominal mouse skin. The influence of different film compositions on in vitro drug permeation into receptor fluid were studied using a modified Franz diffusion cell. The cumulative amount of drug was found to be proportional to the square root of time, i.e., Higuchi kinetics. From this study, it was concluded that the films composed of povidone:ethylcellulose (1:2) should be selected for the development of transdermal drug-delivery system of diltiazem hydrochloride, using a suitable adhesive layer and backing membrane, for potential therapeutic use.     

膜控释盐酸二甲双胍缓释片的研制

制备膜控释盐酸二甲双胍缓释片并对其体外释放度的相关影响因素进行研究。以释放度作为判断原则,采用薄膜包衣法,通过正交试验确定最佳处方和工艺,制得盐酸二甲双胍缓释片,并对溶出方法、转速和溶出介质等因素进行考察,确定了制备盐酸二甲双胍包衣片的最佳处方和工艺。本制剂工艺简单,所用各种辅料成本低,制得盐酸二甲双胍包衣片释放度符合规定。     

盐酸奥布卡因的合成

以3-羟基-4-硝基苯甲酸(2)为原料,经酯化制得3-羟基-4-硝基苯甲酸乙酯(3),3与1-溴丁烷成醚后,再经水解脱保护基制得关键中间体3-丁氧基-4-硝基苯甲酸(5)。另用2-二乙胺基乙醇(6)经氯化亚砜氯化制得2-(二乙胺基)氯乙烷盐酸盐(7)。5与7经缩合制得3-丁氧基-4-硝基苯甲酸2-(二乙胺基)乙酯(8)后成盐酸盐9,最后经Pd/C催化氢化还原硝基即可得到盐酸奥布卡因(1),总收率为67.2%(以2计)。     

影响盐酸苯海拉明水溶液澄明度的原因剖析

利用高效液相色谱、红外光谱等分析测试手段，对盐酸苯海拉明中存在的各种杂质进行了全面剖析，并对各杂质含量进行了定量测定，阐述了影响产品水溶液澄明度的原因。这一剖析结果对产品的生产工艺及质量控制均有重要的指导意义。     

超微重晶石特级粉制造工艺中的制氟防腐方法

研究并提出用稀盐酸、硼酸和反应助剂作为含有萤石、方解石杂质的重晶石粉体酸漂增白的新配方。新配方可以有效抑制氟化物对酸漂设备的腐蚀；生产的超微特级粉中的硫酸钡含量达９９％以上，产品白度（Ｒ４５７标）达９３。此种特级粉的各项技术指标均优于目前国内外同类粉体。     

磷钾伴生矿酸浸液除氯过程的研究

采用蒸馏法去除磷钾伴生矿的盐酸浸出液(酸浸液)中的氯离子,同时回收盐酸。研究了不同种类盐酸盐(AlCl3、MgCl2、CaCl2、KCl)和硫酸对蒸馏过程的影响,结果表明:其它条件相同时,含不同种类盐酸盐的盐酸馏出液中HCl含量的大小顺序依次为:MgCl2AlCl3CaCl2KCl;加入硫酸后,馏出液中HCl含量增加,而不同种类盐酸盐对盐酸蒸馏的影响差异变小;向磷钾伴生矿酸浸液中加入化学计量的硫酸,当有80%的液体被蒸出时(沸程为109.2~124.4℃),体系中78%的氯离子被脱除。     

Agglomeration behavior of petal-shaped cerium carbonate with different operating conditions

Agglomeration phenomenon can often be observed during the fabrication process of petal-shaped,nano-sized Ce_2(CO_3)_3 powders. This kind of powder was produced by liquid-phase precipitation method with the template agent of polyallylamine hydrochloride(PAH). In this study, the effects of the polymer concentration, pH value, and stirring speed on the agglomeration phenomenon of cerium carbonate were investigated. On the condition that the concentration of PAH is 0.9 g·L^-1,the pH value of the adjusting solution is 3-4. the final pH value is 8-10, and the stirring speed is 300-400 r·min^-1, it is found that the agglomeration phenomenon of Ce_2(CO_3)_3 particles can be greatly prevented and the regular petalshaped particles are formed.     

Preparation of ZnFe2O4–chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics

In this study, the structural morphology and magnetic effects of magnetic ZnFe₂O₄ nanoparticles loaded with the cancer-fighting drug doxorubicin hydrochloride (DOX-HCl) were investigated. These nanoparticles have been found to have potential biomedical applications in targeted drug-delivery systems. The zinc ferrite nanoparticles were prepared by a chemical coprecipitation method and coated with chitosan. The nanoparticles were loaded with DOX-HCl and their surfaces improved by folic acid, which can be activated to target specific cancer cells. The specific absorption rate (SAR) values of the ZnFe₂O₄–chitosan–DOX-HCl nanoparticles were investigated at a frequency of 200 kHz and 1.5 kA/m amplitude in order to obtain Brownian relaxation time parameters. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and ultraviolet–visible spectrophotometry (UV–vis) were used to characterize the bulk properties of these nanoparticles. In addition, the impact of the nanoparticles under an alternating current (AC) magnetic field and their heat-generation ability were investigated using an experimental setup. The average nanoparticle size was found to be 8.5 nm. Magnetic hysteresis loops confirmed the superparamagnetism of the nanoparticles. The saturation magnetization was 6 emu/g. UV–vis was used to measure the amount of drug loaded onto the nanoparticles. The amount of drug absorption was significantly higher after 12 h, totaling 75%. The specific absorption rate parameter was 80.66 W/g, and the Brownian relaxation time was 188×10⁻⁹ s.     

CdTe/CdS量子点荧光猝灭法测定盐酸西替利嗪

建立一种基于纳米材料的荧光性质测定盐酸西替利嗪含量的新方法,盐酸西替利嗪能使硫化镉包被的碲化镉核壳型量子点(CdTe/CdS QDs)发生规律性的荧光猝灭,研究二者相互作用的最佳条件,从而建立测定盐酸西替利嗪含量的方法。结果表明:盐酸西替利嗪的浓度在0.40~42μg/m L范围内有良好的线性关系(r=0.9992),检测限为2.50×10-2μg/m L,回收率为93.80%~97.00%。结论:此方法简便、快捷、可靠,适用于盐酸西替利嗪的含量测定。     

3,5-二氯-2-戊酮的合成研究

以α-氯-α-乙酰基-γ-丁内酯、固体光气为原料,N,N-二甲基哌啶盐酸盐为催化剂合成了3,5-二氯-2-戊酮。考察了催化剂种类、氮气通入速率、物料配比、滴加时间、滴加温度等因素对反应的影响。优化条件下,3,5-二氯-2-戊酮的含量94.0%,收率81.5%(以α-氯-α-乙酰基-γ-丁内酯计)。