强化反应器中厌氧颗粒污泥的形成过程

本文就啤酒废水处理过程中厌氧颗粒驯化过程及微生物群落等进行光学显微镜和扫描电镜跟踪观察和研究。结果表明，厌氧序批式反应器(Anaeroibc Sequencing Batch Reactor．ASBR)在处理啤酒废水过程中，厌氧颗粒污泥的形成过程分五个阶段，即细菌增殖阶段、小颗粒污泥形成阶段、小颗粒污泥聚合阶段、初生颗粒污泥阶段和成熟颗粒污泥阶段。     

中国植物空间分异规律

以省级行政区为分析单元,借助ArcGIS空间分析功能对中国行政分区图、中国森林覆盖率图、中国植物区系图、中国植被分区图进行叠加分析。通过对同一植被分区下分析单元数据进行整合,给出全国不同植物区系、植被分区、森林覆盖率信息。采用二阶聚类综合判别法,提取中国植被分区总体信息,探求植被空间分异规律,发现一类、二类、三类植被的比例为30∶37∶23,反映出植被的区域分布特性较强;四类植被比例大致占10%,反映出大区域内部的局地小生境造成的植被分布的整体差异。另外,一类植被多分布在中高纬度地带,二类植被贯穿中国全纬度,三类植被多分布在低纬度地带。     

基于肠道菌群探讨葛根芩连汤治疗湿热型2型糖尿病研究进展*

摘 要: 近年来世界范围内2型糖尿病(Diabetes Mellitus type 2,T2DM)的发病率不断上升。微生态学研究证实,T2DM疾病的发生与肠道菌群数量及比例的失调有很大的关联性,这成为研究热点。现有实验发现:肠道菌群紊乱可通过短链脂肪酸学说、胆汁酸代谢学说、内毒素学说、支链氨基酸学说等机制来影响T2DM的发生发展。湿热证T2DM患者在临床最为常见,该类患者胰岛素抵抗最为严重,而动物实验研究发现葛根芩连汤可通过特定的分子机制及通路作用于肠道菌群,通过调节胰岛β细胞的功能、提高胰岛素敏感性、减轻氧化应激反应,从而调节血糖,减轻胰岛素抵抗,为临床治疗T2DM患者提供更科学的依据。但由于菌群数量庞杂,现有数据多偏重于动物实验,且研究菌群特异性不足,为此今后需进一步加强对T2DM特定菌群的研究,以及增加临床大样本数据统计。     

Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal‐of‐Entry

Although numerous toxicological studies have been performed on carbon nanotubes (CNTs), a few studies have investigated their secondary and indirect effects beyond the primary target tissues/organs. Here, a cascade of events are investigated: the initiating event and the subsequent key events necessary for the development of phenotypes, namely CNT‐induced pro‐inflammatory effects on iron homeostasis and red blood cell formation, which are linked to anemia of inflammation (AI). A panel of CNTs are prepared including pristine multiwall CNTs (P‐MWCNTs), aminated MWCNTs (MWCNTs‐NH₂), polyethylene glycol MWCNTs (MWCNTs‐PEG), polyethyleneimine MWCNTs (MWCNTs‐PEI), and carboxylated MWCNTs (MWCNTs‐COOH). It has been demonstrated that all CNT materials provoke inflammatory cytokine interleukin‐6 (IL‐6) production and stimulate hepcidin induction, associated with disordered iron homeostasis, irrespective of exposure routes including intratracheal, intravenous, and intraperitoneal administration. Meanwhile, PEG and COOH modifications can ameliorate the activation of IL‐6‐hepcidin signaling. Long‐term exposure of MWCNTs results in AI and extramedullary erythropoiesis. Thus, an adverse outcome pathway is identified: MWCNT exposure leads to inflammation, hepatic hepcidin induction, and disordered iron metabolism. Together, the combined data depict the hazardous secondary toxicity of CNTs in incurring anemia through inflammatory pathway. This study will also open a new avenue for future investigations on CNT‐induced indirect and secondary adverse effects.     

禹州华夏植物群与含煤地层研究

通过对河南禹州华夏植物群与含煤地层的研究可知,河南省禹州市神垕镇与磨街乡之间的大风口一带,石炭二叠纪含煤地层出露总厚度超过950 m,最多含煤层数达89层,华北与华南所有的含煤层位在这里几乎都可以找到天然露头,成为研究我国华北晚古生代聚煤盆地的一根"铁柱子",对对比河南省煤田地质勘查和地层具有重要的标杆作用.所产植物化石已鉴定有112属306种;其中,137个为新种,分属12个植物类别.此外,剖面上还有多层可用于烧制钧瓷的黏土矿层.     

臭氧对生物增强活性炭系统中菌群稳定性影响研究

为提高生物增强活性炭(BEAC)工艺的生物稳定性,进行臭氧工艺对固定的优势菌群稳定性的影响研究。结果表明,臭氧投加量1.5～2.5mg/L,接触时间大于10min时,可有效杀灭进水中的杂菌,且产生的余臭氧量(小于0.25mg/L)不会影响后续工艺中优势菌群的生物活性。通过对比臭氧—BEAC和单独BEAC工艺滤料表面菌群组成随运行时间的变化规律,臭氧—BEAC工艺优势菌在活性炭表面始终占主导地位,菌种组成及生态结构未发生改变,有较好的生物稳定性。单独BEAC工艺运行至6个月时,菌群组成发生较大变化,优势菌数量减少。通过扫描电镜观察,运行6个月的臭氧—BEAC炭上形成菌体重叠的菌团结构,并有较多未被生物覆盖的滤料表面和空缺的地方。单独BEAC工艺活性炭表面粗糙结构较少,被大量污染物与菌团相互包裹的颗粒所覆盖。     

星座卫星通信系统资源动态平衡模型的研究

资源动态平衡在星座卫星通信系统中具有重要的作用。针对目前星座卫星通信系统中影响资源平衡的因素,将宏观经济理论原理应用到资源平衡调配领域。从通信任务满足度出发,提出了基于虚拟工厂的资源动态平衡模型,详细阐述了模型中的3C评估指标体系,并以铱系统为例进行评估,验证了3C评估的可行性和有效性。通过模型的构建与求解,得出了星座卫星通信系统内、外部环境、用户需求及资源使用释放随时间推移和空间转换发生改变的关联关系,以及整个星座卫星通信系统达到帕累托最优的具体条件。资源动态平衡问题的研究,为解决星座卫星通信系统中的资源调配问题奠定了基础。     

Optimal homeostasis necessitates bistable control

Bistability is a fundamental phenomenon in nature. In biology, a number of fine properties of bistability have been identified. However, these properties are only consequences of bistability at the physiological level, which do not explain why it had to emerge during evolution. Using optimal homeostasis as the first principle, I find that bistability emerges as an indispensable control mechanism. It is the only solution to a dilemma in glucose homeostasis: high insulin efficiency is required to confer rapidness in plasma glucose clearance, whereas an insulin sparing state is required to guarantee the brain''s safety during fasting. The optimality consideration renders a clear correspondence between the molecular and physiological levels. This new perspective can illuminate studies on the twin epidemics of obesity and diabetes and the corresponding intervening strategies. For example, overnutrition and sedentary lifestyle may represent sudden environmental changes that cause the lose of optimality, which may contribute to the marked rise of obesity and diabetes in our generation. Because this bistability result is independent of the parameters of the mathematical model (for which the result is quite general), some other biological systems may also use bistability to control homeostasis.     

The Innate Immune Glycoprotein Lactoferrin Represses the Helicobacter pylori cag Type IV Secretion System

Chronic infection with Helicobacter pylori increases risk of gastric diseases including gastric cancer. Despite development of a robust immune response, H. pylori persists in the gastric niche. Progression of gastric inflammation to serious disease outcomes is associated with infection with H. pylori strains which encode the cag Type IV Secretion System (cag T4SS). The cag T4SS is responsible for translocating the oncogenic protein CagA into host cells and inducing pro-inflammatory and carcinogenic signaling cascades. Our previous work demonstrated that nutrient iron modulates the activity of the T4SS and biogenesis of T4SS pili. In response to H. pylori infection, the host produces a variety of antimicrobial molecules, including the iron-binding glycoprotein, lactoferrin. Our work shows that apo-lactoferrin exerts antimicrobial activity against H. pylori under iron-limited conditions, while holo-lactoferrin enhances bacterial growth. Culturing H. pylori in the presence of holo-lactoferrin prior to co-culture with gastric epithelial cells, results in repression of the cag T4SS activity. Concomitantly, a decrease in biogenesis of cag T4SS pili at the host-pathogen interface was observed under these culture conditions by high-resolution electron microscopy analyses. Taken together, these results indicate that acquisition of alternate sources of nutrient iron plays a role in regulating the pro-inflammatory activity of a bacterial secretion system and present novel therapeutic targets for the treatment of H. pylori-related disease.