Absorption of materials by or through the living skin

The skin comes into contact with a large range of materials either deliberately or inadvertently. It should be possible to predict the exact transport rates of these materials through the skin as a function of the physicochemical properties of the different compounds. With this sort of knowledge it is possible to predict the exact disposition of compounds and use this in the formulation of new products both in the pharmaceutical and cosmetic field. The information will also be useful from the standpoint of skin toxicology and environmental health. In order to be able to predict this complex process it is necessary to split the overall transport into different component parts. This article will identify these components and provide illustrations. The major areas discussed will be barrier function of the skin, the release properties of different topical formulations and how these may be monitored. Novel means of enhancing the penetration of drugs will be discussed and how some additives that are incorporated into formulations will perhaps alter the barrier function of skin. A mathematical model describing skin penetration has been developed and its use in predicting blood levels will be described. This model has been tested both in animal experiments and in limited human studies and its relevance to these situations will be highlighted.
Absorption cutanée et transcutanée in vivo     

介质周期结构色散特性的严格分析：一种三维边值问题的求解方法

本文以耦合模理论和Ｆｌｏｑｕｅｔ理论为基础，把本征模展开与空间谐波展开巧妙地结合起来，严格分析了斜入射情况下介质周期结构的色散特性－三维边值问题。这种新方法既避免了通常耦合模方法分析此类问题所引入的微扰近似，又比Ｆｌｏｑｕｅｔ方法简单方便。通过对斜入射情况下一些介质结构滤波特性的数值分析，证实了本文方法的有效性，精确性和实用性。     

临南油田夏52块沙三中泥质砂岩油层精细评价

临南油田夏 5 2块沙三中泥质砂岩油层分布广 ,未动用程度高 ,为了稳定产量 ,急需寻找可直接投产的泥质砂岩油层。本文利用相渗实验资料建立油相相对渗透率与含水饱和度关系 ,从而建立有效渗透率的解释模型。依据有效渗透率和有效厚度将泥质砂岩油层划分等级 ,分区评价 ,这不仅有利于合理开采和保护此类油层 ,降低其生产成本 ,也为预测此类油层产能提供依据     

27keV Ar~+斜入射时的Cu-Au合金溅射实验角分布

用27keV Ar~+分别在垂直和倾斜入射情况下,轰击了Cu-Au(30wt％)合金样品,测量了Cu和Au原子的溅射角分布。角分布是用卢瑟福背散射(RBS)技术分析Al捕获膜上的Cu-Au沉积成分而定量得到的。结果表明:(1)在Ar~+倾斜(θ=40°)入射时,Cu原子择优发射,且程度比垂直入射(θ_r=O°)时增强:(2)倾斜入射时,Cu原子的角分布显示出在接近于样品表面法线方向的发射角范围内(θ<45°),发射机率比垂直入射时减小。     

钢板侵彻过载的三维数值模拟

利用LS—DYNA有限元程序，用弹塑性模型建立材料模型，对高速弹丸侵彻均质钢板问题进行了数值模拟，并与测试结果进行了比较，说明了有限元分析的有效性，为引信设计提供参考。     

QP19-L型PDC钻头在TK320井的应用

针对塔河地区的地层特点和PDC钻头的破岩机理，优选了适合于该地层钻进的QP19-L型PDC钻头，总结了PDC钻头的使用技术措施。在TK320井二开井段的应用表明，该钻头能明显提高机械钻速，缩短钻井周期，值得推广应用。     

Subsurface Characterization at Ground Failure Sites in Adapazari, Turkey

Ground failure in Adapazari, Turkey during the 1999 Kocaeli earthquake was severe. Hundreds of structures settled, slid, tilted, and collapsed due in part to liquefaction and ground softening. Ground failure was more severe adjacent to and under buildings. The soils that led to severe building damage were generally low plasticity silts. In this paper, the results of a comprehensive investigation of the soils of Adapazari, which included cone penetration test (CPT) profiles followed by borings with standard penetration tests (SPTs) and soil index tests, are presented. The effects of subsurface conditions on the occurrence of ground failure and its resulting effect on building performance are explored through representative case histories. CPT- and SPT-based liquefaction triggering procedures adequately identified soils that liquefied if the clay-size criterion of the Chinese criteria was disregarded. The CPT was able to identify thin seams of loose liquefiable silt, and the SPT (with retrieved samples) allowed for reliable evaluation of the liquefaction susceptibility of fine-grained soils. A well-documented database of in situ and index testing is now available for incorporating in future CPT- and SPT-based liquefaction triggering correlations.     

模拟爆炸成形弹丸对大间隔靶的侵彻实验研究

为考察爆炸成形弹丸(EFP)的飞行特性及侵彻威力，用火炮发射长径比为1．5的钢EFP模拟弹丸，其着靶速度在1300m/s左右。对大间隔的多层A3薄钢靶板进行侵彻，利用高速摄影了EFP在靶间飞行姿态变化，对其侵彻过程及机理进行了分析，实验结果和分析表明，所设计的EFP具有较为理想的飞行稳定性，对多层间隔靶的侵彻能力强，为设计攻击舰艇等装甲目标的战斗部提供了较重要的参数。     

Estimation of Load Capacity of Pipe Piles in Sand Based on Cone Penetration Test Results

Pipe piles can be classified as either closed- or open-ended piles. In the present paper, the load capacity of both closed- and open-ended piles is related to cone penetration resistance qc through an experimental program using calibration chamber model pile load tests and field pile load tests. A total of 36 calibration chamber pile load tests and two full-scale field pile load tests were analyzed. All the test piles were instrumented for separate measurement of each component of pile load capacity. Based on the test results, the normalized base resistance qb/qc was obtained as a function of the relative density DR for closed-ended piles, and of both the relative density DR and the incremental filling ratio (IFR) for open-ended piles. A relationship between the IFR and the relative density DR is proposed as a function of the pile diameter and driving depth. The relationship between IFR and DR allows the estimation of IFR and thus of the pile load capacity of open-ended piles at the design stage, before pile driving operations.