药用辅料对CYP3A活性的影响及其对仿制药质量和疗效一致性评价的指导作用

药物制剂的处方和工艺是保证药物质量和疗效的基础，药用辅料是药物制剂处方的重要组成部分。部分药用辅料可影响CYP3A的活性，继而可能影响其底物在体内的代谢和生物利用度。在中国和美国，相对生物利用度是仿制药研究的关键内容。我国正在推进仿制药质量和疗效一致性评价。因此，了解药用辅料对CYP3A的影响及其对一致性评价的指导作用具有十分重要的现实意义。     

Annealing and doping-dependent magnetoresistance in single layer poly(3-hexyl-thiophene) organic semiconductor device

We compare the current density–voltage (J–V) and magnetoconductance (MC) response of a poly(3-hexyl-thiophene) (P3HT) device (Au/P3HT(350 nm)/Al) before and after annealing above the glass transition temperature of 150 °C under vacuum. There is a decrease of more than 3 orders of magnitude in current density due to an increase of the charge injection barriers after de-doping through annealing. An increase, approaching 1 order of magnitude, in the negative MC response after annealing can be explained by a shift in the Fermi level due to de-doping, according to the bipolaron mechanism. We successfully tune the charge injection barrier through re-doping by photo-oxidation. This leads to the charge injection and transport transitioning from unipolar to ambipolar, as the bias increases, and we model the MC response using a combination of bipolaron and triplet-polaron interaction mechanisms.     

Simultaneous accommodation of Dy3+ at the lattice site of β-Ca3(PO4)2 and t-ZrO2 mixtures: Structural stability,mechanical, optical,and magnetic features

Structurally stable β-Ca₃(PO₄)₂/t-ZrO₂ composite mixtures with the aid of Dy³⁺ stabilizer were accomplished at 1500°C. The precursors comprising Ca²⁺, P⁵⁺, Zr⁴⁺, and Dy³⁺ have been varied to obtain five different combinations. The results revealed the fact that complete phase transformation of calcium-deficient apatite to β-Ca₃(PO₄)₂ occurred only at 1300°C, whereas the evidence of t-ZrO₂ crystallization is obvious at 900°C. The dual occupancy of Dy³⁺ at β-Ca₃(PO₄)₂ and t-ZrO₂ structures was evident; however, Dy³⁺ initially prefers to occupy β-Ca₃(PO₄)₂ lattice until its saturation limit and thereafter accommodates at the lattice site of ZrO₂. The typical absorption and emission behavior of Dy³⁺ were noticed in all the systems and, moreover, the surrounding symmetry of Dy³⁺ domains has been determined from the luminescence study. All the systems ensured paramagnetic response that is generally contributed by the presence of Dy³⁺. A gradual increment in the phase content of t-ZrO₂ in the composite mixtures ensured a significant improvement in the hardness and Young's modulus of the investigated compositions.     

垦71井区三维VSP资料波场分离方法应用研究

三维VSP资料是多偏移距VSP资料，资料中多种类型的波叠合在一起形成复杂波场。从复杂波场中分离出单一的保幅反射波波场是三维VSP波场分离的重要工作。常规二维VSP波场处理方法单一，难以适用于复杂的三维波场处理。针对三维VSP资料的波场特点，以分离上行反射P波为例，将单一波场分离方法加以适当组合，对垦71井区三维VSP实际资料进行了应用研究。结果表明，波场分离处理中叠加消去法和中值滤波相结合以及F—K滤波和中值滤波相结合的方法克服了单一方法的缺陷，波场处理后获得了波组特征明显、波场清晰单一的上行反射P波保幅波场，取得了较好的波场分离效果。     

氯甲烷在镁修饰的ZSM-5分子筛催化剂上催化转化研究

在镁修饰的ZSM-5分子筛催化剂上,氯甲烷可以被催化转化为烃类产品。分别采用了离子交换和浸渍的方法来修饰ZSM-5分子筛。离子交换的Mg-ZSM-5催化剂和浸渍的Mg/ZSM-5催化剂都可以提高反应产物中的低碳烯烃的选择性,降低烷烃的选择性,并且保持较高的反应活性,但高的浸渍量对反应活性有一定的影响。NH3-TPD的结果表明,浸渍镁的ZSM-5催化剂的强酸中心数目明显减少。镁的修饰对催化剂酸性的影响导致了产物中低碳烯烃的增加。浸渍Mg的ZSM-5催化剂是潜在氯甲烷转化生成低碳烯烃的催化剂。     

Trimble GPS接收机新技术介绍

本文结合当前物探行业的测量设备、测量技术手段及多年的工作经验，对GPSTrimble系列的5700、TrimmarkⅡ、Trimmark3、TSCe使用技巧以及测线放样的技巧做了简明扼要的描述。