桥梁美学2020度年研究进展

本文通过梳理过去一年国内外桥梁美学的发展状况,从桥梁美学思想与理论,桥梁美学设计方法与理论,桥梁景观设计与改造,桥梁规划设计,桥梁历史文化设计与研究,新技术在桥梁美学设计中的应用,桥梁美学设计应用实践等方面阐述了桥梁美学的发展成就;对将来的研究热点和发展方向进行了简要预测;提出了建议和观点,希望对桥梁美学理论和设计实践有所裨益。     

Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2

Inhibition of coronavirus (CoV)-encoded papain-like cysteine proteases (PL^pro) represents an attractive strategy to treat infections by these important human pathogens. Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl) benzamide ( 2 b ), which is known to bind into the S3 and S4 pockets of the SARS-CoV PL^pro. Moreover, we report the discovery of isoindolines as a new class of potent PL^pro inhibitors. The studies also provide a deeper understanding of the binding modes of this inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture suggesting that, due to the high structural similarities of the target proteases, inhibitors identified against SARS-CoV PL^pro are valuable starting points for the development of new pan-coronaviral inhibitors.     

课程思政理念融入“动态图形设计”课程的探索——以制作“我的足球梦”宣传片为例

思政教育在高等职业教育中的地位越来越重要,教师在教学设计过程中要将课程思政融入课程教学,坚持以人为本、立德树人,使各类专业课程与思想政治理论课同向同行。以高职“动态图形设计”课程为例,探索将思政内容融入到专业课程教学中的方法,使学生在设计动画作品的同时,接受思政教育,培养学生正确的思想观、道德观和价值观。     

275/70R22.5 BY568智能公交专用全钢载重子午线轮胎的设计

介绍275/70R22.5 BY568智能公交专用全钢载重子午线轮胎的设计。结构设计:外直径971 mm,断面宽279 mm,行驶面宽度242 mm,行驶面弧度高8.3 mm,胎圈着合直径569.2 mm,胎圈着合宽度222 mm,断面水平轴位置(H1/H2)1.011,胎面采用纵向折沟花纹变节距设计,花纹深度21 mm,花纹周节数60,花纹饱和度79.6%。施工设计:胎面采用全分层结构,胎体采用3×0.24+9×0.225CCHT钢丝帘线,1#带束层采用4+6×0.30HT钢丝帘线,2#和3#带束层采用3+8×0.33ST钢丝帘线,4#带束层采用5×0.35HI钢丝帘线,采用一次法三鼓成型机成型,双模硫化机、氮气工艺硫化。成品轮胎性能试验结果表明,成品轮胎充气外缘尺寸、强度性能和耐久性能均满足国家标准要求。     

235/75R15 FRD78非对称花纹雪地轮胎的设计

介绍235/75R15 FRD78非对称花纹雪地轮胎的设计。结构设计:外直径722 mm,断面宽241 mm,行驶面宽度179 mm,行驶面弧度高7.5 mm,胎圈着合直径375 mm,胎圈着合宽度197.8 mm,断面水平轴位置(H₁/H₂)0.97729,胎面采用4条纵向花纹沟槽设计,花纹深度9 mm,花纹饱和度69.18%,花纹周节数36。施工设计:胎面采用分层挤出,胎侧采用双复合设计,冠带层采用锦纶66帘线,1^#和2^#带束层使用3×0.30HT钢丝帘线,胎体采用高模量低收缩聚酯帘线,采用一次法成型机成型、液压硫化机和氮气硫化工艺硫化。成品性能试验结果表明,轮胎的充气外缘尺寸、强度性能、耐久性能和高速性能均达到相应设计和企业标准要求。     

综合管廊电气工程的相关问题研究

城市综合管廊是现代城市建设的重要综合系统,其电气工程设计工作需要关注供电电源、接地系统、照明设计、电气设备防潮、电缆敷设等关键环节。     

600 MW级亚临界W火焰锅炉设计优化

针对第一代600 MW级亚临界W火焰锅炉存在的过热器减温水量大、大屏过热器超温、排烟温度高、低负荷再热蒸汽温度偏低、NO x生成浓度高等问题,主要从炉膛选型、受热面积调整、节流孔设计优化、燃烧系统空气分级等方面进行方案优化,完成了第二代600 MW级亚临界W火焰锅炉开发。结果表明:第二代600 MW级亚临界W火焰锅炉主要性能较第一代锅炉有明显的提升。     

后置导叶对潮汐双向贯流式机组性能的影响

潮汐双向贯流式水轮机与常规贯流式水轮机的重要区别在于其需要兼顾正向和反向来流工况。为了均衡提升双向贯流式水轮机正反向运行条件下的性能,针对某潮汐双向贯流式水轮机,本文采用商业软件ANSYS CFX,研究了不同后置导叶位置和数量对双向贯流式水轮机性能及内部流动特性的影响。对比结果可知,后置导叶位置和后置导叶数量对机组反向发电时的性能影响较大,后置导叶安放位置系数为0.5和后置导叶数量为8时,机组总体性能较好。随着后置导叶数量增加,正向工况时尾水管水力损失减小,后置导叶通道水力损失反而增大;反向工况时转轮水力损失不断减小,转轮效率逐渐增大。研究成果为潮汐双向贯流式水轮机关键过流部件的优化设计提供技术参考。     

Exploring the methods on improving CH4 delivery performance to surpass the Advanced Research Project Ageney-Energy target

CH_4 storage associated with adsorbed natural gas(ANG) technology is an issue attracting great concern.Following the Advanced Research Project Agency-Energy(ARPA-E) targeted deliverable capacity of 315 cm~3·cm~(-3)(STP), hundreds of thousands of materials have been experimentally or theoretically evaluated,while the best results still show a 35% gap from the target. Moreover, recent theoretical research reveals that the target is beyond the possibility that real materials can be designed. To get rid of the awkward situation, we make attempts on investigating the CH_4 delivery performance under other operation conditions. Methods of raising the discharge temperature(to infinite high) or elevating the storage pressure(to 25 MPa) have been proved to show limited effectiveness. In this work, it is found that the ARPA-E target can be achieved by using a decreasing storage temperature strategy. By taking 280 Co RE(computation-ready, experimental) COFs(covalent organic frameworks) as ANG materials, when reduce the storage temperature to 190.6 K, the highest deliverable capacity can reach 392 cm~3·cm~(-3)(STP), and16.1% Co RE COFs can surpass the target. The target is also achievable when storage at 220 K. Structure performance relationships study shows strong correlation between deliverable capacity and void fraction. Hence, 120 hypothetical COFs are generated to ascertain the optimum void fraction. In addition,the performance of 2 D-COFs can be greatly enhanced by increasing the interlayer spacings, e.g. CH_4 deliverable capacity(storage at 190.6 K) of ATFG-COF can be improved from 239 to 411 cm~3·cm~(-3)(STP) when interlayer spacing is enlarged to 1.65 nm.     

计及需求响应的区域综合能源系统双层优化调度策略

需求响应聚合商通过需求响应聚合用户的可转移负荷和可削减负荷,提高区域综合能源系统运行的灵活性和经济性。考虑综合能源系统运营商和需求响应聚合商之间的交互博弈关系,建立了计及需求响应的区域综合能源系统双层优化调度模型。上下层分别以区域综合能源系统运营商和需求响应聚合商经济收益最大为目标,利用KKT条件和线性化方法将双层模型转化为单层混合整数线性优化模型进行求解。结果显示,通过分时电价和需求响应补偿价格引导用户调整用能计划,可在提高综合能源系统运营商和需求响应聚合商的利润的同时实现削峰填谷,减少对电网安全稳定运行造成的影响。