一种改进的视网膜图像中微小动脉瘤的检测算法

基于糖尿病性视网膜病变中最早出现的微小动脉瘤病症进行了研究,提出一种有效的微小动脉瘤检测算法。首先在传统模板匹配算法的基础上提出了一种动态多参数模板匹配算法,并且使用相对误差和与相关系数来共同制约匹配度,从而实现了更为精确的匹配提取;其次提出了基于分布特性的计分策略和自适应加权的汇总策略,避免了单纯采用各个特征量作为独立约束指标进行筛选时忽视各个特征量的约束力大小的弊端。实验结果表明,该检测算法能够有效地提高微小动脉瘤的检测真阳性率。     

The synthesis and characterization of the molecular sieve SAPO-16 as well as other SAPO and CoAPO phases using bis(cyclopentadienyl) cobalt(III) hydroxide as a structure directing agent

The clathrate type molecular sieve SAPO-16 was prepared via a hydrothermal synthesis using bis(cyclopentadienyl)cobalt(III) hydroxide, Cp₂CoOH, as a template and characterized by XRD, FT-IR, UV-Vis and SEM. Additionally, the preparation and characterization of possibly new isostructural SAPO-UTD-3 and CoAPO-UTD-3 materials is reported.NSF Presidential Young Investigator 1991–1996.     

基于近似弧长参数化的机器人轨迹规划

主要研究了采用近似弧长参数化的插值方法进行关节式工业机器人的轨迹规划.运用近似弧长参数化的插值方法将机器人末端轨迹参数曲线离散为等弧长的插值点序列,通过机器人逆向运动学求解各关节的位移点序列,采用极限的方法进行各关节速度和加速度规划.这种轨迹规划方法可以避免关节空间的插值计算和雅克比矩阵的计算.在 matlab7.8平台上,对近似弧长参数化的插值方法、轨迹规划及可行性验证进行了实例仿真,仿真结果表明该轨迹规划方法是可行的.     

参数线性规划问题的新型光滑精确罚函数神经网络

针对不等式约束条件下,目标函数和约束条件中含有参数的线性规划问题,提出一种基于新型光滑精确罚函数的神经网络计算方法．引入误差函数构造单位阶跃函数的近似函数,给出一种更加精确地逼近于Ll精确罚函数的光滑罚函数,讨论了其基本性质;利用所提光滑精确罚函数建立了求解参数线性规划问题的神经网络模型,证明了该网络模型的稳定性和收敛性,并给出了详细的算法步骤．数值仿真验证了所提方法具有罚因子取值小、结构简单、计算精度高等优点．     

Semiglobal synchronization of multiple generic linear agents with input saturation

This paper investigates the semiglobal synchronization problem for a group of agents with input saturation under directed interaction topology, where each agent is modeled as a generic linear system rather than the single‐integrator or double‐integrator dynamics. The main result is the construction of a feedback coupling gain that achieves semiglobal synchronization if all the agents have identically saturated linear dynamics, which can be of any order. It is shown that the coupling gain obtained via parametric Lyapunov equations can semiglobally synchronize any directed network provided that the interaction topology has a directed spanning tree. Furthermore, due to the use of parametric Lyapunov equations, a convergence rate is analytically obtained. Finally, a simulation example is provided to demonstrate the effectiveness and advantages of our theoretical findings. Copyright © 2013 John Wiley & Sons, Ltd.     

Interpolymer complex microparticles based on polymethacrylic acid‐chitosan for oral insulin delivery

In the present study, microparticles composed of polymethacrylic acid‐chitosan (PMAA‐CS) were prepared by a novel interionic gelation method. Free‐radical polymerization of methacrylic acid was carried out in the presence of CS, using a water‐soluble initiator, and application of these microparticles toward oral insulin delivery was evaluated. Microparticles obtained were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) studies. From SEM studies, it was observed that microparticles had an aggregated morphology with size ～20 μm, while FTIR confirmed the presence of ionic interaction between PMAA and CS chains. Protein loading was done by diffusion filling method, and from in vitro release study, it was observed that insulin‐loaded microparticles displayed a pH depended release profile at alkaline/acidic pH. Microparticles exhibited sustained release of insulin for 3–4 h at neutral pH, and enzyme linked immunosorbent assay (ELISA) proved that encapsulated protein maintained 100% biological activity at neutral pH. Preliminary study suggests that these microparticles can serve as good candidate for oral protein delivery. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 506–512, 2006     

基于Pro/TOOLKIT异步模式特征识别方法

对Pro／Engineer（Pro／E）二次开发工具Pro／TOOLKIT（PTC公司为Pro／E软件提供的二次开发工具包）的异步模式进行了研究，充分利用参数化技术，开发了实体模型的特征识别系统。系统可以控制Pro／E的自动启动及关闭，使其在后台运行。通过模型的调用实现实体特征的快速识别提取，为模具估价系统的智能化设计做好了准备。     

Viscoelastic properties and morphology of sulfonated poly(styrene-b-ethylene/butylene-b-styrene) block copolymers (sBCP), and sBCP/[silicate] nanostructured materials

Self-assembled organic/inorganic hybrid materials were created via domain targeted sol-gel reactions of tetraethylorthosilicate in solution with sulfonated poly(styrene-b-[ethylene-co-butylene]-b-styrene) (sSEBS) copolymers. Dynamic mechanical analyses (DMA) of these hybrid materials suggest that the silicate component preferentially incorporates within the sulfonated polystyrene (PS) domains. An irreversible order-order transition (OOT) for unmodified SEBS, sSEBS, and the organic/inorganic hybrids was identified using DMA in shear mode. The OOT temperature increases with sulfonation as well as by adding a silicate phase by the sol-gel process. The DMA results imply a morphological shift with sulfonation, and reflect modified interactions within and between phases. Atomic force microscopy (AFM) indicated a shift from hexagonally packed cylinders in unmodified SEBS to a lamellar morphology in the sulfonated materials, but silicate incorporation did not affect the morphology or domain dimensions. The latter result is evidence for sol-gel polymerization templating in a self-assembly process. The phase-separated morphology is stable up to the degradation temperature of the polymer and thermogravimetric analysis revealed that the degradation temperature is unaffected by silicate incorporation. Small angle X-ray scattering data are in harmony with the structures revealed by AFM in terms of degree of order and scale of features. These results are largely rationalized in terms of chain mobility restrictions due to hydrogen-bonding interactions between different sulfonated PS blocks, an increase in the PS-ethylene/butylene block mixing parameter, increased interfacial surface tension and chain restrictions posed by inserted silicate nanostructures in the case of the hybrid materials.     

Synthesis and characterization of porous media produced by a sol-gel method

Mesoporous silica materials were synthesized by sol-gel method using tetraethoxysilane (TEOS) as precursors and surfactants i.e., cetyltrimethyl ammonium bromide (CTAB), sodium dodecyl sulfate (SDS), and polyoxyethylene cetyl ether (Brij 56) as templates. Surfactant templates were completely removed by calcination to form mesoporous structure. The effects of type and amount of surfactants on the characteristics of samples were studied. The textural characteristics such as surface area, pore volume, pore size, and pore size distribution were determined by nitrogen sorption isotherms. Fourier transform infrared (FTIR) spectroscopy was employed to qualitatively identify the chemical functionality and to confirm the removal of surfactant template. Scanning electron microscope (SEM) and transmission electron microscope (TEM) were used to directly observe surface morphology and mesoporous structure, respectively. The adsorption capacity of the synthesized adsorbent for toluene vapor was examined. We found that the pore volume and pore size of mesoporous materials affected the adsorption capacity. The sample prepared with high content of CTAB under basic condition (pH ∼7) yielded large pore volumes and pore sizes and subsequently possessed the high adsorption capacity for toluene vapor.     

Preparation of Mesoporous Ni–alumina Catalyst by One-step Sol–gel Method: Control of Textural Properties and Catalytic Application to the Hydrodechlorination of o-dichlorobenzene

Mesoporous Ni–alumina catalysts (Ni–alumina-pre and Ni–alumina-post) were synthesized by one-step sol–gel method using micelle complex comprising lauric acid and nickel ion as a template with metal source and using aluminum sec-butoxide as an aluminum source. The Ni–alumina catalysts showed relatively high surface areas (303 m²/g for Ni–alumina-pre and 331 m²/g for Ni–alumina-post) and narrow pore size distributions centered at ca. 4 nm. Highly dispersed Ni particles were observed in the Ni–alumina catalysts (ca. 5.2 nm for Ni–alumina-pre and ca. 6.8 nm for Ni–alumina-post) after reduction at 550 °C, while a catalyst prepared without a template (NiAl-comp) exhibited inferior porosity with large metal particles (ca. 12.3 nm). Mesoporous Ni–alumina catalysts with different porosity were obtained by employing different hydrolysis step of aluminum source. When aluminum source was hydrolyzed under the presence of micelle complex, a supported Ni catalyst with highly developed framework mesoporosity was obtained (Ni–alumina-post). On the other hand, when aluminum source was pre-hydrolyzed followed by mixing with micelle solution, the resulting catalyst (Ni–alumina-pre) retained high portion of textural porosity. It was revealed that the hydrolysis method employed in this research affected not only textural properties but also metal-support interaction in the Ni–alumina catalysts. It was also found that the Ni–alumina-pre catalyst exhibited weaker interaction between nickel and alumina than the Ni–alumina-post, leading to higher degree of reduction in the Ni–alumina-pre catalyst. In the hydrodechlorination of o-dichlorobenzene, the Ni–alumina catalysts exhibited better catalytic performance than the NiAl-comp catalyst, which was attributed to higher metal dispersion in the Ni–alumina catalysts. In particular, the Ni–alumina-pre catalyst showing 1.5 times higher degree of reduction and larger amounts of o-dichlorobenzene adsorption exhibited better catalytic performance than the Ni–alumina-post catalyst.