视频处理器软硬件协同设计

为了提高视频图像处理速度与硬件资源利用,针对一种基于精简指令集处理器与数字信号处理器（RISC/DSP）混合体系结构的媒体处理器：浙大数芯（MD32）,给出了一种软硬件协同设计策略.所给策略结合视频处理核心算法,研究分析MPEG视频编码标准的处理过程,进行了视频处理指令扩展设计,提高了数据的并行处理能力,利用了指令内并行执行特性.为有效实现扩展指令,处理器执行级采用了可扩展流水级技术.实验结果表明,指令扩展硬件成本仅占MD32的2.7%,逆离散余弦变换实现性能比MMX/SSE指令集实现的性能分别提高31%和23%,运动补偿性能比MMX指令集实现的性能提高了40%.     

基于事件触发的电力系统H∞优化控制

针对大规模集中用电导致电力系统负荷端激增从而影响电力系统稳定性的问题,提出一种基于事件触发的H_∞优化控制方式。本文采用扇区法对单机无穷大电力系统进行线性化处理,之后通过模糊逻辑建立电力系统的T-S模糊模型。通过事件触发理论和模糊逻辑利用并行分布补偿(parallel distribution compensation,PDC)的方法设计系统控制器。H∞优化控制相比于传统的控制方法提高了系统的稳定性及抗干扰能力,因此本文根据李雅普诺夫稳定性理论和H∞优化控制理论,基于线性矩阵不等式(linear Matrix Inequality,LMI),给出了保证单机无穷大电力系统闭环渐进稳定的充分条件,并采用MATLAB仿真软件对系统进行仿真,从而证明稳定条件的存在。     

Elucidation of the Clustered Nano-Architecture of Radiation-Induced DNA Damage Sites and Surrounding Chromatin in Cancer Cells: A Single Molecule Localization Microscopy Approach

In cancer therapy, the application of (fractionated) harsh radiation treatment is state of the art for many types of tumors. However, ionizing radiation is a “double-edged sword”—it can kill the tumor but can also promote the selection of radioresistant tumor cell clones or even initiate carcinogenesis in the normal irradiated tissue. Individualized radiotherapy would reduce these risks and boost the treatment, but its development requires a deep understanding of DNA damage and repair processes and the corresponding control mechanisms. DNA double strand breaks (DSBs) and their repair play a critical role in the cellular response to radiation. In previous years, it has become apparent that, beyond genetic and epigenetic determinants, the structural aspects of damaged chromatin (i.e., not only of DSBs themselves but also of the whole damage-surrounding chromatin domains) form another layer of complex DSB regulation. In the present article, we summarize the application of super-resolution single molecule localization microscopy (SMLM) for investigations of these structural aspects with emphasis on the relationship between the nano-architecture of radiation-induced repair foci (IRIFs), represented here by γH2AX foci, and their chromatin environment. Using irradiated HeLa cell cultures as an example, we show repair-dependent rearrangements of damaged chromatin and analyze the architecture of γH2AX repair clusters according to topological similarities. Although HeLa cells are known to have highly aberrant genomes, the topological similarity of γH2AX was high, indicating a functional, presumptively genome type-independent relevance of structural aspects in DSB repair. Remarkably, nano-scaled chromatin rearrangements during repair depended both on the chromatin domain type and the treatment. Based on these results, we demonstrate how the nano-architecture and topology of IRIFs and chromatin can be determined, point to the methodological relevance of SMLM, and discuss the consequences of the observed phenomena for the DSB repair network regulation or, for instance, radiation treatment outcomes.     

方波工况下PMSM单电流调节器控制策略的研究

轨道交通领域中的永磁同步电机PMSM(permanent magnet synchronous motor)在高速区通常运行在方波工况,电机电压幅值达到最大值时失去调节能力,仅有电压矢量角可供调节,导致传统的基于双电流环的控制策略失效。通过对方波工况下转矩与电压相角、d轴和q轴电压以及电流与电压相角、d轴和q轴电压关系的推导,可得方波工况下有6种不同的单电流环控制策略,目前应用于方波工况下的单电流环控制策略属于这6种控制策略之一。通过建立小信号模型,对这6种控制策略的稳态性能以及动态性能进行分析比较。最后通过仿真以及实验研究证明了理论分析的正确性。     

Characterization of the Functional Cross-Talk between Surface GABAA and Dopamine D5 Receptors

The γ-aminobutyric acid type A receptor (GABA_AR) plays a major role in fast inhibitory synaptic transmission and is highly regulated by the neuromodulator dopamine. In this aspect, most of the attention has been focused on the classical intracellular signaling cascades following dopamine G-protein-coupled receptor activation. Interestingly, the GABA_AR and dopamine D5 receptor (D5R) have been shown to physically interact in the hippocampus, but whether a functional cross-talk occurs is still debated. In the present study, we use a combination of imaging and single nanoparticle tracking in live hippocampal neurons to provide evidence that GABA_ARs and D5Rs form dynamic surface clusters. Disrupting the GABA_AR–D5R interaction with a competing peptide leads to an increase in the diffusion coefficient and the explored area of both receptors, and a drop in immobile synaptic GABA_ARs. By means of patch-clamp recordings, we show that this fast lateral redistribution of surface GABA_ARs correlates with a robust depression in the evoked GABAergic currents. Strikingly, it also shifts in time the expression of long-term potentiation at glutamatergic synapses. Together, our data both set the plasma membrane as the primary stage of a functional interplay between GABA_AR and D5R, and uncover a non-canonical role in regulating synaptic transmission.     

窑尾框架主次梁单夹板连接关键问题研究

主次梁的单夹板连接在窑尾框架的主次梁连接中使用广泛,本文对这种连接形式的关键问题,如是否对长节点抗剪承载力进行折减,摩擦型高强螺栓如何界定是否产生滑移以及有限元模拟下的真实承载力进行了研究,给出了可供参考的结论。     

单晶高温合金定向凝固过程中初生碳化物的上浮现象SCIEI

本文在一种抗热腐蚀单晶镍基高温合金平面及胞状液-固界面定向凝固条件下,发现了初生碳化物(TiC)的上浮现象并分析了其形成原因。     

海洋平台大厚度焊接接头断裂韧度

依据BS7448断裂韧度试验标准(ISO／TC164／SC4-N400)，对采用埋弧焊(SAW)工艺施焊的、板厚为54mm的海洋石油平台大厚度对接接头试样进行了低温裂纹尖端张开位移(CTOD)试验。分别测试了-15℃下单丝和双丝埋弧焊工艺下焊缝金属和热影响区的CTOD值。试验表明，除双丝埋弧焊热影响区试件外，其余试件均满足挪威船级社DNV规定的最小特征CTOD为0．15mm的要求，为指导海洋平台的施工建造提供了科学依据。     

单级单开关不连续导电模式功率因数校正电路新方案

分析了几种单级单开关不连续导电、带输出电压隔离的功率因数校正电路，分别讨论了其优缺点，并提出了一种新的功率因数校正电路。     

热型连铸单晶铜工艺参数对铸棒表面质量的影响

在自行设计，制造的横引式热型连铸设备上对影响连铸过程的各工艺参数进行试验，并就各工艺参数对铸件表面质量的影响机理进行了分析。结果表明，各工艺参数主要是通过影响固液界面在型口中的位置来影响铸棒的表面质量，只有对各工艺参数进行合理匹配，才能得到表面光滑的铸棒，此外，液位高度变化即液位波动，也会对铸棒的表面质量产生 一定影响。