药用硫酸钙的研制

本文首次报道以贝壳为原料制造药用硫酸钙的实验过程,研究了影响硫酸钙品质的主要因素,指出硫核钙作为片剂辅料的优良性能。     

近红外反射光谱分析在抗生素片剂质量控制中的应用

本文讨论了近红外反射光谱分析在头孢片剂固体样品物理化学性质测定方面的应用，分析结果显示该方法可以很好的确认生产过程中的原料及其制品的质量，同时还可以得到满意的水分含量测定结果。     

主成分分析法神经网络及其在瑞培林片剂测定中的应用

介绍了主成分分析法神经网络的基本原理，对瑞培林片剂进行了测定，回收率令人满意，讨论了此法在复方制剂多组分同时测定中的优越性，并研究了网络拓扑结构、学习速率等对结果的影响。     

Evaluation and comparison of five matrix excipients for the controlled release of acrivastine and pseudoephedrine

For treatment of allergic rhinitis, acrivastine with pseudoephedrine in Semprex®-D conventional capsules requires dosing every 6-8 hours. This study was designed to develop a controlled release matrix tablet of acrivastine and pseudoephedrine and evaluate 5 different matrix excipients for their in vitro controlled-release profiles. Compritol® 888ATO, Eudragit® RS, Methocel® K100M, Polyox® WSR301 and Precirol® ATO5 were used alone or in varying combinations for the formulation of controlled release matrix tablets. In vitro drug dissolution and mathematical modeling were used to characterize drug release rate and extent. All tablet formulations yielded quality matrix preparations with satisfactory tableting properties. Due to the aqueous solubility of pseudoephedrine and the size of the dose, none of the matrix excipients used alone prolonged drug release significantly to meet the desired twice-daily administration frequency. The use of two excipients in combination, however, significantly decreased the dissolution rate of both active ingredients. A combined lipid-based Compritol® and hydrophilic Methocel® produced optimal controlled drug release for longer than 8 hours for both acrivastine and pseudoephedrine.     

Learning to use new technologies by older adults: Perceived difficulties,experimentation behaviour and usability

This paper examines the factors and theoretical frameworks for the adoption of technology for older adults, and proposes two models of technology acceptance and rejection, one from an ease of learning perspective, and one from a system and user perspective. Both models are supported from reports on two case studies of older adults using handheld touchscreen tablet devices; one in which the participants are supported during tasks primarily related to walking and navigation, and one in which participants are unsupported in communication related tasks. The first study shows the powerful role that facilitating conditions have for learning how to use digital technologies for this user group, whether supporting through step by step guidance, providing a friendly space to use trial and error methods, and/or provision of a manual. The second study shows the pitfalls of a lack of facilitating conditions during initial use, and highlights potential for appropriate design in helping to avoid some user errors during this phase.     

Evaluation of dibutyrylchitin as new excipient for sustained drug release

Dibutyrylchitin (DBC), a lipophilic chitin diester, has been synthesized from chitin and butyric anhydride with methanesulfonic acid as catalyst. Exhaustive esterification of free alcoholic groups of chitin was assessed by FT-IR and ¹H-NMR spectroscopy. High degree of alkyl substitution allowed DBC to acquire an almost completely lipophilic character. Tablets of paracetamol and metformin employing DBC as major excipient, in comparison with starch, microcrystalline cellulose, lactose and polyvinylpyrrolidone, were prepared and rates of drug release were checked by dissolution test assays. DBC released drug at a lower rate than that of the other tested materials. A comparison study of rate release of metformin from DBC tablets and from metformin-hydroxypropyl methylcellulose prolonged release oral formulation available on the market has been also curried out. Under the same conditions and in the presence of the same amount of loaded drug, DBC released 64% of metformin whereas hypromellose-based tablets released 87%.     

基于数码平板的GAP视觉自动检测系统设计

针对目前数码平板的边框与屏幕之间的缝隙对其外观质量的影响和缝隙检测精度的要求,设计开发了数码平板的GAP视觉自动检测系统。首先根据待检测平板的结构特征,给出了检测系统的机械结构简图,并对该系统的检测流程作简单阐述。再借助计算机视觉理论,采用二次滤波、膨胀与腐蚀算法,并借助图像处理软件,实现了数码平板的GAP图像自动检测与质量分类,加强了检测的可靠性。     

激光超声波无损检测片剂硬度方法的研究

为了清楚地了解片剂的硬度与超声波速度之间的关系,利用激光照射到片剂上,通过测定出反射的声表面波速度,且对实验数据进行分析,从而得出片剂的硬度与声表面波速度之间的关系曲线。实验结果表明,随着片剂硬度的增加,反射的声表面波速度会减小。因此在片剂无损检测或在线快速检测等方面会有一定的研究价值。     

二甲硝咪唑盐片剂的制备及体外溶出度

采用紫外分光光度法，对用淀粉、糊精和微晶纤维素等辅料制备的二甲硝咪唑盐片剂和二甲硝咪唑片剂，进行了体外溶出度和释药动力学的比较研究，结果表明：在人工肠液中，两者累积释药50％的时间分别为7.59min和18.26min，前者的溶出速率明显快于后者，本品在45min内可溶解805以上，释药规律符合Weibull方程。     

炭黑分散度检测标准GB/T 18251应用过程中遇到的问题浅析

主要对GB/T 18251—2019《聚烯烃管材、管件和混合料中颜料或炭黑分散度的测定》标准中给出的炭黑分散度检测过程中试样厚度范围、厚度测量方法及切片法中试样形状、试样幅宽、试样制备过程中遇到的问题做了讨论研究。试样厚度是制备试样的一个重要参数,标准中未给出具体测量方法,应予以补充,建议采用显微镜测量法。标准中给出的炭黑分散度试样厚度范围（20±10）μm不合适,实际检测过程中发现能用于试验的试样厚度小于10μm。标准中未给出切片法制备试样的形状和幅宽,建议使用正方形试样,幅宽4 mm,切片过程中可能会遇到无法切到指定厚度范围的试样,可以采用低温冷冻后再切样的办法解决。