全文获取类型
收费全文 | 271篇 |
免费 | 24篇 |
专业分类
电工技术 | 1篇 |
化学工业 | 118篇 |
金属工艺 | 6篇 |
机械仪表 | 9篇 |
建筑科学 | 13篇 |
矿业工程 | 2篇 |
能源动力 | 4篇 |
轻工业 | 49篇 |
水利工程 | 2篇 |
石油天然气 | 1篇 |
无线电 | 3篇 |
一般工业技术 | 55篇 |
冶金工业 | 10篇 |
自动化技术 | 22篇 |
出版年
2023年 | 4篇 |
2022年 | 2篇 |
2021年 | 29篇 |
2020年 | 13篇 |
2019年 | 9篇 |
2018年 | 10篇 |
2017年 | 21篇 |
2016年 | 14篇 |
2015年 | 12篇 |
2014年 | 9篇 |
2013年 | 28篇 |
2012年 | 18篇 |
2011年 | 28篇 |
2010年 | 16篇 |
2009年 | 18篇 |
2008年 | 19篇 |
2007年 | 13篇 |
2006年 | 5篇 |
2005年 | 4篇 |
2004年 | 4篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 5篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1986年 | 1篇 |
1981年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有295条查询结果,搜索用时 376 毫秒
31.
Monika Šupová Tomáš Suchý Zbyněk Sucharda Elena Filová Job N. L. M. der Kinderen Marie Steinerová Lucie Bačáková Gražyna Simha Martynková 《Journal of the American Ceramic Society》2019,102(5):2882-2904
Eight different calcium phosphate nanoparticles, namely bovine bone bioapatite calcined at 500, 600, and 700°C, Mg-doped brushite, fluorinated calcium phosphate, Ca-deficient hydroxyapatite, hydroxyapatite, and tricalcium phosphate, were characterized employing physico-chemical methods. Their cytocompatibility was evaluated under human osteoblast-like cell line MG-63 culture conditions in elution media and via the direct interaction of cells with calcium phosphate nanoparticles. The main objective was to determine the correlation of the cell indices with the differently determined physical and chemical parameters of the calcium phosphates. Chemical composition, which contributes toward pH changes, and the calcium ion concentration in the medium appear to make up particularly significant factors; moreover, it was proved that the number of material types represents a further important aspect. In the case of a large number of material types, almost no correlation was determined between the analyzed parameters; however, in the case of a small number of apatite types, several positive correlations were found. It can be concluded that it is not possible to identify any monitored parameters that had a major impact on cell behavior or, at least, such an effect which can be generalized. It appears more likely that cell behavior is affected by the interplay of various parameters. 相似文献
32.
Temporal trends of synthetic musk compounds in mother's milk and associations with personal use of perfumed products 总被引:3,自引:0,他引:3
Lignell S Darnerud PO Aune M Cnattingius S Hajslova J Setkova L Glynn A 《Environmental science & technology》2008,42(17):6743-6748
We analyzed two nitro musks (musk xylene and musk ketone) and five polycyclic musks (HHCB, AHTN, ADBI, ATII, and AHDI) in mother's milk from primiparae women (N = 101) living in Uppsala County, Sweden, 1996-2003. Possible temporal trends in musk concentrations and associations with lifestyle/medical factors, such as use of perfumed products during pregnancy were studied. HHCB showed the highest median concentration (63.9 ng/g lipid) followed by AHTN (10.4 ng/g) and musk xylene (MX) (9.5 ng/g). Concentrations of the other substances were, in most cases, below the quantification limit (2.0-3.0 ng/g). Women with a high use of perfume during pregnancy had elevated milk concentrations of HHCB, and elevated concentrations of AHTN were observed among women reporting use of perfumed laundry detergent. This strongly suggests that perfumed products are important sources of musk exposure both among the mothers and the nursed infants. Concentrations of AHTN and MX declined significantly between 1996 and 2003, suggesting a decline in the industrial use of the compounds in consumer products, or alterations in the consumer use pattern of perfumed products. No temporal trend in HHCB concentrations was seen. The lack of toxicity data makes it difficult to generalize about the safety of musk exposure of breast-fed infants. 相似文献
33.
Patrick Borel Faiza Hammaz Lucie Lecourt Grégory Marconot Guillian Gillet Camille Rozier Charles Desmarchelier 《Molecular nutrition & food research》2023,67(12):2200798
Scope
Turmeric curcuminoids mainly consist of curcumin (CUR), demethoxycurcumin (dCUR), and bisdemethoxycurcumin (bdCUR). CUR displays low bioavailability, partly due to poor solubilization in the intestinal lumen during digestion, while data for dCUR and bdCUR are scarce. The study aims to investigate the bioaccessibility of curcuminoids from turmeric extracts or from gamma-cyclodextrins, considering potential interactions with food.Methods and results
Using an in vitro digestion model (correlation with CUR bioavailability: r = 0.99), the study shows that curcuminoid bioaccessibility from turmeric extract without food is low: bdCUR (11.5 ± 0.6%) > dCUR (1.8 ± 0.1%) > CUR (0.8 ± 0.1%). Curcuminoids incorporated into gamma-cyclodextrins display higher bioaccessibilities (bdCUR: 21.1 ± 1.6%; dCUR: 14.3 ± 0.9%; CUR: 11.9 ± 0.7%). Curcuminoid bioaccessibility is highest without food (turmeric extract: 2.0 ± 0.1%; gamma-cyclodextrins: 12.4 ± 0.8%) and decreases with a meat- and potato-based meal (turmeric extract: 1.1 ± 0.2%; gamma-cyclodextrins: 2.4 ± 0.3%) or a wheat-based meal (turmeric extract: 0.1 ± 0.0%; gamma-cyclodextrins: 0.3 ± 0.1%). Curcuminoids exhibit low (<10%) incorporation efficiencies into synthetic mixed micelles (bdCUR > dCUR > CUR).Conclusions
bdCUR and dCUR show greater bioaccessibilities versus CUR. Food diminishes curcuminoid bioaccessibility, likely by adsorption mechanisms. Gamma-cyclodextrins improve curcuminoid bioaccessibility. 相似文献34.
Lucie Čechovská Karel Cejpek Michael Konečný Jan Velíšek 《European Food Research and Technology》2011,233(3):367-376
Despite available reports on phenolic composition and antioxidant capacity (AOC) of fresh plums and prunes, there is a scarcity
of published knowledge on the antioxidants formed and/or released during the drying process in the literature. To evaluate
the compounds participating in reducing capacity of prunes, we compared aqueous and methanol extracts of fresh plums, commercial
prunes and home-made prunes prepared at different drying temperatures using an HPLC method with amperometric detection (HPLC-ECD).
The prunes dried at high temperature (90 °C, 18 h) in kitchen or laboratory oven with restricted ventilation gave up to 3.3 times
higher electrochemical capacity (EC) than fresh plums (dry matter; P. domestica cv. Domestica) in dependence on production protocol. Drying at 60 °C (low-temperature drying) for 18 h did not change the
EC significantly. Yet, lower EC was found in commercial tenderized prunes with sorbate; they were by a factor of 1.1–8.2 lower
in EC than the prepared low-temperature prunes. The principle responsible for the increase in EC in the prunes prepared at
high temperatures is 2,3-dihydro-3,5-dihydroxy-6-methyl-(4H)-pyran-4-one (DDMP). It was not detected until 74 °C was set during isothermal 18 h drying or until 6 h of drying passed
at 90oC drying. The ultimate acceptable dwell-time for the preparation of conveniently eatable prunes dried at 90oC under
the conditions used was assessed to 12 h. The EC of plums and prunes as well as the role of DDMP was confirmed by the use
of several methods for the assessment of AOC-DPPH• assay, β-carotene bleaching method, Oxipres test and Schaal oven test. 相似文献
35.
Oxana Kazakova Irina Smirnova Elena Tretyakova Ren Csuk Sophie Hoenke Lucie Fischer 《International journal of molecular sciences》2021,22(4)
Semi-synthetic triterpenoids, holding an amino substituted seven-membered A-ring (azepano-ring), which could be synthesized from triterpenic oximes through a Beckmann type rearrangement followed by a reduction of lactame fragment, are considered to be novel promising agents exhibiting anti-microbial, alpha-glucosidase, and butyrylcholinesterase inhibitory activities. In this study, in an attempt to develop new antitumor candidates, a series of A-ring azepano- and 3-amino-3,4-seco-derivatives of betulin, oleanolic, ursolic, and glycyrrhetinic acids were evaluated for their cytotoxic activity against five human cancer cell lines and non-malignant mouse fibroblasts by means of a colorimetric sulforhodamine assay. Azepanoallobetulinic acid amide derivative 11 was the most cytotoxic compound of this series but showed little selectivity between the different human tumor cell lines. Flow cytometry experiments showed compound 11 to act mainly by apoptosis (44.3%) and late apoptosis (21.4%). The compounds were further screened at the National Cancer Institute towards a panel of 60 cancer cell lines. It was found that compounds 3, 4, 7, 8, 9, 11, 15, 16, 19, and 20 showed growth inhibitory (GI50) against the most sensitive cell lines at submicromolar concentrations (0.20–0.94 μM), and their cytotoxic activity (LC50) was also high (1–6 μM). Derivatives 3, 8, 11, 15, and 16 demonstrated a certain selectivity profile at GI50 level from 5.16 to 9.56 towards K-562, CCRF-CEM, HL-60(TB), and RPMI-8226 (Leukemia), HT29 (Colon cancer), and OVCAR-4 (Ovarian cancer) cell lines. Selectivity indexes of azepanoerythrodiol 3 at TGI level ranged from 5.93 (CNS cancer cell lines SF-539, SNB-19 and SNB-75) to 14.89 for HCT-116 (colon cancer) with SI 9.56 at GI50 level for the leukemia cell line K-562. The present study highlighted the importance of A-azepano-ring in the triterpenic core for the development of novel antitumor agents, and a future aim to increase the selectivity profile will thus lie in the area of modifications of azepano-triterpenic acids at their carboxyl group. 相似文献
36.
Lucie Vitejnov Vclav Lika Arvind Kumar Jana Ke
kov Ondej Vy
ítal Jan Brha Jan Bene Yaroslav Kolinko Tereza Blassov Zbynk Tonar Michaela Brychtov Marie Karlíkov Jaroslav Racek Hynek Mírka Petr Hoek Daniel Lysk Milena Krlí
kov 《International journal of molecular sciences》2021,22(9)
In liver surgery, biliary obstruction can lead to secondary biliary cirrhosis, a life-threatening disease with liver transplantation as the only curative treatment option. Mesenchymal stromal cells (MSC) have been shown to improve liver function in both acute and chronic liver disease models. This study evaluated the effect of allogenic MSC transplantation in a large animal model of repeated biliary obstruction followed by partial hepatectomy. MSC transplantation supported the growth of regenerated liver tissue after 14 days (MSC group, n = 10: from 1087 ± 108 (0 h) to 1243 ± 92 mL (14 days); control group, n = 11: from 1080 ± 95 (0 h) to 1100 ± 105 mL (14 days), p = 0.016), with a lower volume fraction of hepatocytes in regenerated liver tissue compared to resected liver tissue (59.5 ± 10.2% vs. 70.2 ± 5.6%, p < 0.05). Volume fraction of connective tissue, blood vessels and bile vessels in regenerated liver tissue, serum levels of liver enzymes (AST, ALT, ALP and GGT) and liver metabolites (albumin, bilirubin, urea and creatinine), as well as plasma levels of IL-6, IL-8, TNF-α and TGF-β, were not affected by MSC transplantation. In our novel, large animal (pig) model of repeated biliary obstruction followed by partial hepatectomy, MSC transplantation promoted growth of liver tissue without any effect on liver function. This study underscores the importance of translating results between small and large animal models as well as the careful translation of results from animal model into human medicine. 相似文献
37.
Nielsen Guillaume Coudert Lucie Janin Amelie Blais Jean Francois Mercier Guy 《Mine Water and the Environment》2019,38(1):104-118
Mine Water and the Environment - Acid mine drainage (AMD) is a major environmental challenge for the mining industry in northern climates. Laboratory-scale experiments were conducted to test... 相似文献
38.
Ira Jiří Hasalová Lucie Šálek Vojtěch Jahoda Milan Vystrčil Václav 《Fire Technology》2020,56(3):1099-1132
Fire Technology - Engineered wood products (EWPs) are a group of materials having a very similar chemical composition but having different and non-uniform thermo-physical properties throughout... 相似文献
39.
40.
Fluorine containing self‐crosslinking acrylic latexes with reduced flammability and their application as polymer binders for heterogeneous cation‐exchange membranes 下载免费PDF全文
Jana Machotova Eliska Stranska Jiri Skornok Lucie Zarybnicka Klara Melanova Jozef Rychly Adela Ruckerova 《应用聚合物科学杂志》2017,134(43)
In this study, self‐crosslinking core–shell latexes comprising copolymerized perfluorethyl groups and a novel flame retardant based on phosphazene derivative were prepared by the semi‐continuous non‐seeded emulsion polymerization of 2,2,2‐trifluorethyl methacrylate, methyl methacrylate, butyl acrylate, methacrylic acid, and hexaallylamino‐cyclo‐triphosphazene as main monomers. For interfacial crosslinking, diacetone acrylamide was copolymerized into the shell layer of latex particles to provide sites for subsequent reaction with adipic acid dihydrazide. The heterogeneous cation‐exchange membranes were obtained by dispersing commercial strong acid cation‐exchange resin powder in the latex binder and casting the mixture followed by keto‐hydrazide crosslinking reaction. It was found that the increased concentration of fluorine atoms and phosphazene units in the macromolecular structure of interfacially crosslinked emulsion polymers resulted in a significant enhancement of their flame resistance and shape stability in aqueous environment. Moreover, the easily prepared heterogeneous cation‐exchange membranes based on latexes with higher amounts of fluorine and phosphazene units were shown to exhibit satisfactory physicochemical and electrochemical properties. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 45467. 相似文献