正常角膜和圆锥角膜的特征提取

基于角膜测量仪器Corvis ST采集的图像视频,提出提取新特征参数以便准确区分正常角膜和圆锥角膜。首先对图像进行滤波、分割等预处理,检测角膜上下边界,并计算前角膜曲率值;用小波变换分析角膜曲率变化,获取与角膜运动趋势相关的特征,包括角膜运动的整体趋势和角膜振动的范数和标准差。然后,基于均方误差最小化法,提取特征参数,构建最优参数。最后,用支持向量机(SVM)对正常角膜和圆锥角膜进行分类。从频率的角度实施的实验显示角膜在基本运动趋势上存在着振动过程。此外,提出的参数优于形变幅度(DA)、峰值距离(PD)等传统参数,使准确度、灵敏度和特异性分别提高了10.2%,5.7%和6.9%。受试者工作特征曲线(ROC)下面积为0.948,接近于1。结果显示本文方法自动提取的特征参数可提高正常角膜和圆锥角膜区分的准确性,对临床诊断有辅助作用。     

Structural dependence of corrosion resistance of amorphous carbon films against nitric acid

To investigate the structural dependence of the corrosion resistance of amorphous carbon (a-C:H) films, three different types of a-C:H films etched by nitric acid were evaluated using a surface plasmon resonance (SPR) device with a multilayer structure consisting of an a-C:H layer on Ag. Two non-hydrogenated amorphous carbon (a-C) films and one hydrogenated a-C:H film were synthesized to estimate the effects of the sp²/sp³ ratio and hydrogenation, respectively. A flow cell for the introduction of nitric acid solution was placed on the amorphous carbon layer of the multilayer structure. A 0.3 mM nitric acid solution was used in the etching tests. The Kretschmann configuration was used for SPR measurement, and the SPR angle was determined as the angle with minimum reflectivity. The SPR angle decreased with increasing duration of nitric acid injection into the flow cell, indicating that the film was corroded by the nitric acid. The thickness of the films was calculated from the SPR angle. The rates of decrease in the thickness were 2.2, 0.8, and 1.6 nm/h for the a-C films with lower and higher sp² contents and the 17 at.% hydrogenated a-C:H film, respectively. Although the hydrogen content had little effect on the rate of change in the film thickness, the film thickness clearly decreased with decreasing sp²/sp³ ratio. These results indicate that the sp²/sp³ ratio is an important factor determining the chemical resistance to nitric acid solution.     

The Mixture of Salvianolic Acids from Salvia miltiorrhiza and Total Flavonoids from Anemarrhena asphodeloides Attenuate Sulfur Mustard-Induced Injury

Sulfur mustard (SM) is a vesicating chemical warfare agent used in numerous military conflicts and remains a potential chemical threat to the present day. Exposure to SM causes the depletion of cellular antioxidant thiols, mainly glutathione (GSH), which may lead to a series of SM-associated toxic responses. MSTF is the mixture of salvianolic acids (SA) of Salvia miltiorrhiza and total flavonoids (TFA) of Anemarrhena asphodeloides. SA is the main water-soluble phenolic compound in Salvia miltiorrhiza. TFA mainly includes mangiferin, isomangiferin and neomangiferin. SA and TFA possess diverse activities, including antioxidant and anti-inflammation activities. In this study, we mainly investigated the therapeutic effects of MSTF on SM toxicity in Sprague Dawley rats. Treatment with MSTF 1 h after subcutaneous injection with 3.5 mg/kg (equivalent to 0.7 LD₅₀) SM significantly increased the survival levels of rats and attenuated the SM-induced morphological changes in the testis, small intestine and liver tissues. Treatment with MSTF at doses of 60 and 120 mg/kg caused a significant (p < 0.05) reversal in SM-induced GSH depletion. Gene expression profiles revealed that treatment with MSTF had a dramatic effect on gene expression changes caused by SM. Treatment with MSTF prevented SM-induced differential expression of 93.8% (973 genes) of 1037 genes. Pathway enrichment analysis indicated that these genes were mainly involved in a total of 36 pathways, such as the MAPK signaling pathway, pathways in cancer, antigen processing and presentation. These data suggest that MSTF attenuates SM-induced injury by increasing GSH and targeting multiple pathways, including the MAPK signaling pathway, as well as antigen processing and presentation. These results suggest that MSTF has the potential to be used as a potential therapeutic agent against SM injuries.     

Triphenyl phosphine oxide-bridged bipolar host materials for green and red phosphorescent organic light-emitting diodes

Two wide band gap functional compounds of phenylbis(4-(spiro [fluorene-9,9'-xanthen]-2-yl)phenyl)phosphine oxide (2SFOPO) and (4-(9-ethyl-9H- carbazol-3-yl)phenyl)(phenyl)(4-(spiro[fluorene-9,9′-xanthen]-2-yl)phenyl)phosphine oxide (SFOPO-CZ) were designed, synthesized and characterized. Their thermal, photophysical, electrochemical properties and device applications were further investigated to correlate the chemical structure of bipolar host materials with the electroluminescent performance for phosphorescent organic light-emitting diodes (PhOLEDs). Both of them show high thermal stability with glass transition temperatures in a range of 105–122 °C and thermal decomposition temperatures at 5% weight loss in a range of 406–494 °C. The optical band gaps of compound 2SFOPO and SFOPO-CZ in CH₂Cl₂ solution are 3.46 and 3.35 eV, and their triplet energy levels are 2.51 eV and 2.52 eV, respectively. The high photoluminescent quantum efficiency of emissive layer of doped green device up to 50% is obtained. Employing the developed materials, efficient green and red PhOLED in simple device configurations have been demonstrated. As a result, the green PhOLEDs of compound SFOPO-CZ doped with tris(2-phenylpyridine) iridium shows electroluminescent performance with a maximum current efficiency (CE_max) of 52.83 cd A⁻¹, maximum luminance of 34,604 cd/m², maximum power efficiency (PE_max) of 39.50 lm W⁻¹ and maximum external quantum efficiency (EQE_max) of 14.1%. The red PhOLED hosted by compound 2SFOPO with bis(2-phenylpyridine)(acetylacetonato) iridium(III) as the guest exhibits a CE_max of 20.99 cd A⁻¹, maximum luminance of 33,032 cd/m², PE_max of 20.72 lm W⁻¹ and EQE_max of 14.0%. Compound SFOPO-CZ exhibits better green device performance, while compound 2SFOPO shows better red device performance in PhOLEDs.     

木-混凝土梁柱组合节点的受力性能试验研究与理论分析

为探索木-混凝土组合梁在框架结构中运用的可行性,借鉴钢结构顶底翼缘角钢连接,提出了角钢混合连接木-混凝土梁柱组合节点形式,并就其受力性能展开了试验与理论研究。试验中共设计了3个节点试件,即木梁-木柱节点、木-混凝土组合梁与木柱组合节点和木-混凝土组合梁与钢柱组合节点,并对其进行低周反复荷载试验。结果表明：提出的角钢混合连接木-混凝土梁柱组合节点具有良好的受力性能,顶底角钢作为最薄弱组件对节点受力性能起关键作用;相较于木梁-木柱节点,在正弯矩作用下,木-混凝土组合梁与木柱组合节点、木-混凝土组合梁与钢柱组合节点的承载力皆提高了约18%,而初始转动刚度分别提高了40.1%和33%。通过引入“组件法”对节点的受力性能进行了理论分析,并将理论结果与试验结果进行了对比,结果表明,采用组件法预测木-混凝土梁柱组合节点的屈服弯矩和初始转动刚度的误差皆低于15%,具有较高精度。     

探地雷达在承压水条件下盾构进出洞环箍注浆质量检测中的应用

上海市轨道交通14号线某区间盾构进出洞时面临承压含水层问题,为保证盾构顺利施工,采用探地雷达探测环箍注浆效果,指导判断衬砌与盾构机之间、衬砌与周围加固土之间的间隙填充情况,以期形成有效的“瓶塞”效应,防止承压水沿管片界面渗入盾构机内部。结合工程实际情况,充分验证了采用探地雷达进行环箍注浆质量检测的可行性,可为类似项目施工提供借鉴。     

Enhanced electrochemical performance of supercapattery derived from sulphur-reduced graphene oxide/cobalt oxide composite and activated carbon from peanut shells

Sulphur-reduced graphene oxide/cobalt oxide composites (RGO-S/Co₃O₄) were successfully synthesized by varying mass loading of Co₃O₄ through a simple hydrothermal method. Structural, morphological, chemical compositional and surface area/pore-size distribution analysis of the materials were obtained by using XRD, Raman spectroscopy, SEM, TEM, EDX, FTIR, XPS and BET techniques, which reveal an effective synthesis of the RGO-S/Co₃O₄ composites. Electrochemical performance of the materials was evaluated using a three- and two-electrode system in 1 M KOH electrolyte. An optimized RGO-S/200 mg Co₃O₄ composite displayed the highest specific capacity of 171.8 mA h g⁻¹ and superior cycling stability of 99.7% for over 5000 cycles at 1 and 5 A g⁻¹, respectively, in a three-electrode system. A fabricated supercapattery device utilizing RGO-S/200 mg Co₃O₄ (positive electrode) and activated carbon from peanut shells (AC-PS) (negative electrode), revealed a high specific energy and power of 45.8 W h kg⁻¹ and 725 W kg⁻¹, respectively, at 1 A g⁻¹. The device retained 83.4% of its initial capacitance for over 10, 000 cycles with a columbic efficiency of 99.5%. Also, a capacitance retention of 71.6% was preserved after being subjected to a voltage holding test of over 150 h at its maximum potential of 1.45 V.