硅钙合金电炉的大型化

简要回顾了我国硅钙合金开发生产的历史过程,特别提到"分层加料法"工艺的创新,为中国硅钙合金的发展做出了贡献,文章对硅钙电炉的大型化提供了定性的理论依据,并提出中国硅钙电炉大型化应走建新炉和利用现有的大型硅铁电炉转炼硅钙合金的可行路线。     

高面密度纤网水刺加固分层与褶皱效应分析

用水刺工艺加固面密度在300g/m2以上的高面密度纤网时,为保证纤维缠结充分,需采用高压水针。若只提高水刺压力,不提高抽吸负压,则会因水针无法穿透纤网造成分层现象,还会因滞留水的影响产生表面褶皱效应。通过试验证实了在提高水刺压力的同时提高抽吸负压的重要性。     

惠南庄泵站计算机监控系统结构及特点

惠南庄泵站是南水北调中线工程唯一的泵站,担负着向北京市供水的重要任务。文中从泵站的工程背景及运行方式出发,提出了泵站计算机监控系统的设计原则,详细阐述了系统的开放式分层分布结构、主要设备的配置及功能,并对系统的主要特点进行了分析与总结,可供大中型泵站计算机监控系统的设计及施工借鉴。     

Improved dissolution rate and bioavailability of fenofibrate pellets prepared by wet-milled-drug layering

Objective: The objective of this study is to investigate the wet-milled-drug layering process which could significantly improve the dissolution rate and oral bioavailability of fenofibrate pellets.

Methods: Fenofibrate was milled with HPMC-E5 to prepare a uniform suspension in the micrometer and nanometer range, and this suspension was then layered on to sugar spheres to form the pellets (F1, F2).

Results: The particle size was significantly reduced (from 1000 µm to 1–10 µm and 400?nm) but the fenofibrate in suspension retained its crystallinity from the results of DSC and PXRD investigations. The dissolution rate of F1-F2 and Antara® capsules was 55.47 %, 61.27 % and 58.43 %, respectively, in 0.01?mol/L SDS solution over 60?min. In addition, F1, F2, and Antara® capsules were given orally to 6 beagle dogs to determine the bioavailability. The C_max of F1, F2 (8.21?±?2.55 and 9.33?±?2.37 μg/mL)and the AUC_(0?t) of F1, F2 (152.46?±?78.89 and 172.17?±?67.58 μg/mL·h)were higher than those of Antara® (6.02?±?3.34 μg/mL and 89.82?±?46.46 μg/mL·h) and, F1, F2 reached their C_max earlier than Antara® (F1: 2.0?±?1.1?h; F2: 1.8?±?1.2?h; Antara®: 6.0?±?8.9?h).

Conclusion: These results show that the wet-milled-drug layering technique is a powerful method to improve the dissolution rate and the bioavailability of fenofibrate.     

Pellet layering: scale-up considerations using different kinds of processing equipment

Objective: In this study an aqueous suspension of poorly water-soluble HCT (hydrochlorothiazide) was layered on small spherical starter cores with a drug content in the final pellets of 30%. The aim was to compare different kinds of processing equipment (Wurster fluid-bed, CPS rotor fluid-bed and drum coater) in view of process efficiency, process duration and feasibility to scale-up.

Results: In a pilot scale drum coater, it was possible to achieve the desired LE (layering efficiency) and yield specifications (both >95%), but the process duration was at least 202?min. In the small scale Wurster fluid-bed machine, it was possible to reduce the process time for an optimized process from 67?min to 41?min. However, the acceleration of the process led to an increase of agglomerates and the same process took at least 114?min in the scale-up experiments. A small scale CPS rotor processor with a cone-shaped disc was superior to the conventional planar rotor disc design, regarding yield and agglomerates. This rotor process was both, fast and highly efficient (yield: 98.4%; LE: 99.3%). The high quality of the process was also observed for the pilot scale batches, in which neither considerable losses of drug (LE ≥ 98.6%) nor formation of agglomerates occurred. The absolute spray rate in this pilot scale process was 85?kg/h.

Conclusion: Best results were achieved with the CPS rotor technology. With a duration of 29?min (small scale) and 44?min (pilot scale) it was the fastest option to produce layered pellets.     

光传送网分层结构与原子功能模型

本文首先介绍光传送网的功能分层结构，然后讲述设备规范方法的演变和原子功能模型，最后简要介绍用原子功能模型描述的光传送网功能块特性。     

地图自动识别系统中按颜色分层的算法及实现

本文研究对彩色地图图象按颜色分层问题．按颜色对地图图象分层是计算机对地图图象进行自动化识别的重要步骤．本文讨论了按颜色分层的算法，探讨了一些影响分层效率和效果的问题，给出了解决这些问题的办法，这些算法已经编程实现，效果理想．     

谈高职院校学生层次化导读服务

导读工作是高校图书馆为学生服务中的一项重要内容,占有特殊的地位。文章从高职院校学生的阅读趋势和就业需要指出了导读的必要性,提出了以建立读者信息库为基础,建立学科信息资源导航的层次化导读服务策略,分析了学生读者阅读类型,有针对性提出了导读服务的措施。     

高集油田高效稳产技术及效果分析

高集油田是江苏油田西斜坡中部的一个中低渗的小断块油藏，针对其特点，在不同的开采阶段采取了不同的井网调整和挖潜措施。实施了初期开发概念设计、稳产过程中局部井网调整、分层注水、递减期井网重组和挖掘剩余油等具体做法．油田连续稳产6年，取得了较好的开发效果。     

纯化油田高压注水井套管损坏原因及防治措施

针对纯化油田实施高压注水以来,注水井套管损伤日益增多的现象,通过现场调研,找出该油田套管损害的主要原因,并从物理和化学两方面提出了防治措施,即在管柱上加设套管保护封隔器和环空保护液,对已发生套损的井应用套管补贴、换套管、注水泥等方法进行治理,矿场已取得较好效果。