表面粗糙度对太赫兹反射测量的影响

材料表面粗糙度会影响太赫兹无损检测结果。当材料表面粗糙度在微波区可以忽略不计时,在波长更短的太赫兹频段则需要考虑在内。研究讨论了在太赫兹频率下粗糙表面散射对反射谱的影响。通过考虑单个样品的反射模型,利用基尔霍夫近似可以将粗糙表面的反射信号与光滑表面的反射信号进行关联。此外,采用太赫兹时域光谱(THz-TDS)系统对不同粗糙度的葡萄糖片进行了测量,并对其反射光谱进行了分析。反射光谱结果表明,由于表面粗糙度引起的漫散射减弱了接收端反射光谱的强度。为了减小粗糙度对光谱的影响,提出了一种能恢复光谱功率的补偿方法。在0.5 THz和1 THz时,具有360目粗糙度规格样品的功率谱分别增加了约3 dB和9 dB。因此,可以认为所提出的粗糙表面光谱补偿方法在未来太赫兹无损检测技术的发展中具有一个特定的参考价值。     

Investigation of the binding free energies of FDA approved drugs against subtype B and C-SA HIV PR: ONIOM approach

Human immune virus subtype C is the most widely spread HIV subtype in Sub-Sahara Africa and South Africa. A profound structural insight on finding potential lead compounds is therefore necessary for drug discovery. The focus of this study is to rationalize the nine Food and Drugs Administration (FDA) HIV antiviral drugs complexed to subtype B and C-SA PR using ONIOM approach. To achieve this, an integrated two-layered ONIOM model was used to optimize the geometrics of the FDA approved HIV-1 PR inhibitors for subtype B. In our hybrid ONIOM model, the HIV-1 PR inhibitors as well as the ASP 25/25' catalytic active residues were treated at high level quantum mechanics (QM) theory using B3LYP/6-31G(d), and the remaining HIV PR residues were considered using the AMBER force field. The experimental binding energies of the PR inhibitors were compared to the ONIOM calculated results. The theoretical binding free energies (?G_bind) for subtype B follow a similar trend to the experimental results, with one exemption. The computational model was less suitable for C-SA PR. Analysis of the results provided valuable information about the shortcomings of this approach. Future studies will focus on the improvement of the computational model by considering explicit water molecules in the active pocket. We believe that this approach has the potential to provide much improved binding energies for complex enzyme drug interactions.     

现代水网建设的区域生态效应可变模糊评价

现代水网建设旨在解决区域水资源短缺、地下水超采以及生态恶化等问题,为了评估现代水网建设的生态功能,对现代水网建设产生的生态效应进行评价。以青州市为研究区域,以2013年为基准年,2020年和2025年为规划年,在50%、75%和95%保证率下,通过青州市现代水网进行水资源优化配置和调度,根据配置和调度结果,选取5个生态效应评价指标,构建生态效应评价指标体系,采用可变模糊评价法,对青州市现代水网建设产生的生态效应进行评价。结果表明,青州市现代水网建设后,生态状况等级比建设前提升了1~3级,生态环境明显改善。因此,区域现代水网建设和生态调度对生态环境改善有重要作用。     

基于FPGA内存数据保护技术的设计与实现

为了提高内存数据的可靠性,内存保护技术正广泛应用在高端容错计算机中。为此,提出了以现场可编程门阵列（FPGA）为控制器实现一拖二的内存热备份技术,对内存数据进行高效的保护。分析FPGA内部接口IP的延时后,提出了采用FPGA原语实现双倍数据速率（DDR）数据的采集与处理方法。搭建了以镁光的同步动态随机存取存储器（SDRAM）颗粒为控制对象的仿真模型,验证了该方法的有效性。阐述了以赛灵思公司的FPGA芯片做主控器,实现内存热备份功能的应用实例。该方法不仅可有效保护内存数据,由于FPGA的可编程性,使计算机系统具备了在线扩展（容量）、在线升级内存的功能,可以满足特殊行业不宕机、实时容错的要求。     

Optimized mobile cloud resource discovery architecture based on dynamic cognitive and intelligent technique

In current world, the Mobile Cloud Computing (MCC) will undergo a dramatic upgrade with integrating of mobile cloud resources in small regions to provide a better MCC service. This paper considers the MCC resource availability problem in integrated mobile cloud environment to optimization resources availability with a better effectiveness, accuracy, reliable, low latency and low complexity. The DCICRD architecture is proposed in this paper optimizes the resource discover process with better resource availability. The proposed DCICRD architecture runs various operations such Resource demand prediction to find the required level of resources, Cloudlet Resource Discovery process which discovers resources based on the requirement predicted using two states expand and shrink. The expand state is used to discover resources on-demand in resource scarcity situation and the shrink state is called when abundant resource available to the required level.  Further, Resource reliability check is performed to identify the reliable resource with energy level and signal strength above the threshold level. Finally, Local Resource Information Management Table is used to store the local resource provider information and Central Resource Information Management Table is used to store all local resource information for handover of resource provider. The implementation and evaluation is conducted by comparing the HARD architecture. The comparison result shows that proposed DCICRD architecture is better than HARD architecture by optimizing the resource discovery process and produce reliable resources on demand as per the required level with a better effectiveness using expand and shrink state, accuracy by making resource available for required level, reliable by sending message for frequent checking of Resource with required energy level and signal strength, low latency by making resource available locally and reduce complexity by performing only on-demand resource discovery operation after initial startup. Thus, the proposed DCICRD architecture is better when compared to HARD architecture.     

堆石混凝土技术在邢家峪水库的应用

通过重力坝结构的设计方案优化,充分利用当地河道的天然石材筑坝,采用自密实堆石混凝土结构。具有工期短、节约工程建设投资和节能低碳环保等优点,不但使坝体强度性能满足C30混凝土的设计要求,施工工期缩短1/3．工程造价节约20％,具有显著的经济效益和社会效益和较大的推广应用前景。     

臭氧/复合吸附深度处理饮用水试验研究

针对水中污染物的特性,从污染物极性角度考虑,将极性无机吸附剂——多孔性软陶粒与活性炭组成复合滤料,提出了臭氧/无机＋有机吸附剂组合强化去除水中污染物的作用机制,开发了臭氧/复合吸附组合工艺,将臭氧氧化、滤料的物理、化学吸附技术有机结合,充分发挥了三者协同作用,对水中污染物具有去除效率高、效果稳定等特点.臭氧/复合吸附组合工艺在最佳工艺条件下,对经常规处理后的济南狼猫山水库水中的浊度、CODMn、UV254、NH3-N和NO2-1-N的去除率分别达到92.2%、87.7%、86.3%、88.6%和92.3%.     

基于VPN技术实现区域性卫生信息系统资源共享的探讨

建设区域性医疗卫生信息系统是我国卫生信息化建设的第三阶段,是实现预防保健、医疗服务和卫生管理为一体化的信息化应用系统.着重探讨如何基于VPN技术,较好地实现软硬件资源的共享及数据传输的安全,同时借助VPN技术,打造“共享协同”的医疗服务模式,实现区域性卫生信息系统资源共享.     

基于支持向量机的纹理图像分类算法

研究纹理图像的分类问题,纹理特征提取和分类器设计是决定分类正确率高低的关键。由于库存图像较多,且质量受到噪声影响,使图像特征提取比较困难。针对传统特征提取和分类算法分类正确率不高的难题,提出一种基于支持向量机的纹理图像分类算法。首先采用Gabor滤波器对纹理特征进行提取,采用主成分分析对提取后的特征进行选择,最后采用支持向量机进行纹理图像的分类。采用Brodatz纹理库进行测试实验,实验结果表明,支持向量机分类算法提高了纹理图像的分类正确率,降低了误分率和拒分率,且分类速度加快,适用于更为复杂的纹理分类,为图像提取提供了参考。