大采高综放工作面强动压端头顶板控制技术

为了解决大采高综放工作面回风侧端头顶板控制问题,针对马道头矿8211工作面的地质情况,通过对回风顺槽超前注浆加固,提高超前支护范围和支护强度,并对回风侧端头三角区煤壁和顶板进行化学浆加固的技术方案,有效控制了顺槽超前区围岩变形和工作面回风侧端头三角区煤壁片帮,保证了工作面端头区顶板安全。     

耦合让均压支护在综采面端头维护的应用

为了提高综采工作面端头超前应力区顶板稳定性,降低顶板支护费用,对8309工作面端头应力区提出了耦合让均压支护技术,控制了端头应力区顶板下沉、破碎现象,可降低支护成本费用320元/m。     

热效应对高速圆锥动静压轴承静特性的影响

为研究热效应对高速圆锥动静压轴承静特性的影响,建立具有深浅腔结构的圆锥动静压轴承的Reynolds方程、能量方程、深腔流量平衡方程及相关控制方程;采用有限元法和有限差分法对其进行离散,运用正系数法则对能量方程系数及常数项的离散系数进行处理,联立求解得到油膜压力分布与温度分布,计算出高速圆锥动静压轴承的静参数,并分析热效应对高速圆锥动静压轴承静特性的影响。结果表明:热效应使高速圆锥动静压轴承油膜压力减小,且转速越大,压力减幅越大,油膜温升越明显;计入热效应后,润滑油黏度降低,引起高速圆锥动静压轴承偏位角增大,轴向、径向承载力减小,端泄流量增大,摩擦力减小,且转速越高变化越显著。     

脂质氧化对肉制品中4 类有害物质形成影响的研究进展

肉制品加工过程中往往伴随着脂质氧化的发生，现有研究表明，脂质氧化能影响肉制品中杂环胺、N-亚硝基化合物、晚期糖基化终末产物及多环芳烃等有害物质的生成，这些物质的积累会降低肉制品的食用安全性并危害人体健康。本文综述了肉制品中脂质氧化的机制及氧化产物的反应活性、脂质氧化对肉制品中上述4 类有害物质形成的影响及相关控制措施，以期从控制脂质氧化的角度出发为肉制品安全性生产工艺提供参考。     

综采工作面端面破碎顶板控制技术应用

针对8103综采工作面过断层应力区期间出现端面距加大,端面破碎现象严重,降低了工作面回采效率,影响支架支护效果,局部区域出现冒落现象,北辛窑矿通过技术研究,对过断层应力区端面破碎顶板维护方案进行了探讨,决定采用注浆锚杆支护技术。通过实际应用,控制了端面顶板破碎现象,降低了端面距,保证了工作面安全高效回采。     

Disseminated tuberculosis: A neglected entity in immunocompromised hemodialysis patients

End‐stage renal disease is considered a factor predisposing to increased risk of tuberculosis with frequent extrapulmonary localization. Although extrapulmonary tuberculosis has been observed for decades, disseminated tuberculosis, a major cause of morbidity and mortality in immunocompromised hosts, remains rather neglected. We report an unusual case of an immunocompromised patient with a late diagnosis and delayed treatment of genitourinary tuberculosis that subsequently led to the diagnosis of vertebral and miliary tuberculosis (disseminating tuberculosis). Therefore, increased awareness is warranted from physicians dealing with hemodialysis patients in order to avoid delays in diagnosis and treatment initiation.     

RB Regulates DNA Double Strand Break Repair Pathway Choice by Mediating CtIP Dependent End Resection

Inactivation of the retinoblastoma tumor suppressor gene (RB1) leads to genome instability, and can be detected in retinoblastoma and other cancers. One damaging effect is causing DNA double strand breaks (DSB), which, however, can be repaired by homologous recombination (HR), classical non-homologous end joining (C-NHEJ), and micro-homology mediated end joining (MMEJ). We aimed to study the mechanistic roles of RB in regulating multiple DSB repair pathways. Here we show that HR and C-NHEJ are decreased, but MMEJ is elevated in RB-depleted cells. After inducing DSB by camptothecin, RB co-localizes with CtIP, which regulates DSB end resection. RB depletion leads to less RPA and native BrdU foci, which implies less end resection. In RB-depleted cells, less CtIP foci, and a lack of phosphorylation on CtIP Thr847, are observed. According to the synthetic lethality principle, based on the altered DSB repair pathway choice, after inducing DSBs by camptothecin, RB depleted cells are more sensitive to co-treatment with camptothecin and MMEJ blocker poly-ADP ribose polymerase 1 (PARP1) inhibitor. We propose a model whereby RB can regulate DSB repair pathway choice by mediating the CtIP dependent DNA end resection. The use of PARP1 inhibitor could potentially improve treatment outcomes for RB-deficient cancers.     

压力室结构对断油阶段空化及气体倒流的影响

断油阶段的空化现象对喷油间隔期的流场有重要影响,空化引起的高温燃气倒流会造成孔内结焦,进而影响缸内射流雾化.基于可视化试验和流体体积(VOF)方法两相三组分多相流求解器,对柴油喷嘴断油阶段的流动过程进行试验和模拟,分析3种不同压力室壁面曲率结构的喷嘴对断油阶段空化及气体倒流的影响.结果表明:在断油阶段喷孔和压力室依次发生空化现象,其中压力室内空化量较大,并呈现为涡空化和带状空化两种形态,壁面曲率小的狭直结构以带状空化为主;压力室结构较为狭直的喷嘴空化体积变大,但其低压持续时间延长使柴油流出量变小,最终导致倒流气体量下降;在发生涡空化时,速度梯度张量第二不变量Q与涡空化体积呈正相关,涡核区域越小则流场中磨擦耗散越少,越易于压力室内空化的形成.     

密实度对桩端承载力影响的离散元分析

为探究土体密实度对桩基的滑动面和破坏机理产生的影响,采用PFC3D软件模拟浅埋条件下的单桩在密实和松散砂土中的载荷试验,从微观角度揭示密实和松散两种状态对桩端承载机理的影响。结果表明,在桩端承载力与沉降位移的关系曲线中,密实地基的桩端阻力存在明显的峰值并出现沉降软化,松散地基的桩端阻力不断增大;通过颗粒速度场随桩体位移的变化,密实地基的破坏面与MEYERHOF G G提出的破坏面类似,松散地基的破坏面与VESIC A S提出的冲剪破坏面和局部剪切破坏面类似;通过颗粒位移场随桩体位移的变化,密实地基桩端附近土体发生侧向挤压和隆起而松散地基桩端土体仅发生严重的侧向挤压;通过分析地基破坏后的颗粒接触力,密实地基的力链有沿桩端向桩端以上的地基边界和桩身发展的趋势,松散地基的力链集中在桩底以下并向下传递;通过孔隙比和应力状态随加载过程的变化可知,密实地基发生土体剪胀,松散地基发生土体剪缩。     

新型8MN/3MN钢管管端加厚机的开发

介绍新型8MN3 MN钢管管端加厚机的整体结构,重点分析其肘杆增力机构原理;通过与传统钢管管端加厚机的对比发现,研发的新型肘杆增力机构式钢管管端加厚机具有结构简单,生产效率高,性能稳定,节能降耗效果显著等优势。