Systemic Inflammation and the Breakdown of Intestinal Homeostasis Are Key Events in Chronic Spinal Cord Injury Patients

Our aim was to investigate the subset distribution and function of circulating monocytes, proinflammatory cytokine levels, gut barrier damage, and bacterial translocation in chronic spinal cord injury (SCI) patients. Thus, 56 SCI patients and 28 healthy donors were studied. The levels of circulating CD14^+highCD16⁻, CD14^+highCD16⁺, and CD14^+lowCD16⁺ monocytes, membrane TLR2, TLR4, and TLR9, phagocytic activity, ROS generation, and intracytoplasmic TNF-α, IL-1, IL-6, and IL-10 after lipopolysaccharide (LPS) stimulation were analyzed by polychromatic flow cytometry. Serum TNF-α, IL-1, IL-6 and IL-10 levels were measured by Luminex and LPS-binding protein (LBP), intestinal fatty acid-binding protein (I-FABP) and zonulin by ELISA. SCI patients had normal monocyte counts and subset distribution. CD14^+highCD16⁻ and CD14^+highCD16⁺ monocytes exhibited decreased TLR4, normal TLR2 and increased TLR9 expression. CD14^+highCD16⁻ monocytes had increased LPS-induced TNF-α but normal IL-1, IL-6, and IL-10 production. Monocytes exhibited defective phagocytosis but normal ROS production. Patients had enhanced serum TNF-α and IL-6 levels, normal IL-1 and IL-10 levels, and increased circulating LBP, I-FABP, and zonulin levels. Chronic SCI patients displayed impaired circulating monocyte function. These patients exhibited a systemic proinflammatory state characterized by enhanced serum TNF-α and IL-6 levels. These patients also had increased bacterial translocation and gut barrier damage.     

Botulinum Toxin: From Poison to Possible Treatment for Spasticity in Spinal Cord Injury

Botulism has been known for about three centuries, and since its discovery, botulinum toxin has been considered one of the most powerful toxins. However, throughout the 20th century, several medical applications have been discovered, among which the treatment of spasticity stands out. Botulinum toxin is the only pharmacological treatment recommended for spasticity of strokes and cerebral palsy. Although its use as an adjuvant treatment against spasticity in spinal cord injuries is not even approved, botulinum toxin is being used against such injuries. This article describes the advances that have been made throughout history leading to the therapeutic use of botulinum toxin and, in particular, its application to the treatment of spasticity in spinal cord injury.     

聚酯帘线的发展趋势

从聚酯的结构设计、帘线浸胶工艺和在轮胎中的应用3个方面阐述聚酯结构特点与产品性能的关系。聚酯帘线行业应该密切关注汽车行业的发展态势,把握市场先机,进一步发展壮大;在新能源汽车逆势增长的形势下,高性能聚酯帘线需求量较大,帘线企业应拓展高性能聚酯帘线在轮胎冠带层、带束层和胎体等部件中的应用,同时联合轮胎企业开发特种聚酯材料和混纺材料等新产品。     

松辽盆地南部深层火山岩识别及成藏条件分析

松辽盆地北部徐深1井在营城组火山岩获得油气突破后，在松辽盆地南部长岭断陷针对火山岩部署了长深1井。在长深1井营城组火山岩地层测试获4.6×105m3/d的工业气流，推算无阻流量1.5×106m3/d以上，预示松辽盆地南部深层火山岩气藏是下步勘探开发的主要领域。通过大量的火山岩岩心资料，利用岩石学、矿物学、测井和地震地层学等多学科技术，首次在松辽盆地南部建立了火山岩识别标准，在东南隆起区部署探井1口，在火山岩中见到了较好的气显示，取得很好的效果。     

正确选择气顶油藏高效开发模式

通过对不同类型气顶油藏的油气水分布特征及气顶和边水能量的研究分析，计算水侵量与边水体积及合理的弹性产率。提出适合气顶油藏特点的开发模式是先开采油区后开采气顶，并以唐家河油田港深18—2断块为例，证明采用该模式可以高效开发气顶油藏。图3表1参6     

桩帽处理对灌注桩高应变检测的影响

本文给出砼灌注桩高应变检测中桩帽的施工工艺 ,并讨论其对测试结果的影响。     

Experimental Study on the Effect of Steel-fibre in Conerete Thick Cap

The effect of steel fibre used in concrete was systematically analyzed by model testing of 30 2-pile thick caps of steel-fibre reinforced concrete, in which the model scale was 1：5. The experiment system composed of a loading device, strain measurement system and a data-acquisition system was used, also an electromechanic centigrade scale, a lens and a Y J-25 static resistance strainometer were used.The experimental results show that the volumetric rate of steel fibre and draw ratio have an important influence on its load-bearing capacity. The incorporation of steel fibre can effectively improve the extension and reduce the thickness of the caps.     

Perceived risk for influenza in veterans with spinal cord injuries and disorders.

Objective: Guided by the extended parallel process model (EPPM), the objective was to assess control processes dominant in influenza behavior decisions. Design: Cross-sectional survey. Results: Response rate was 31% (n=968). Regarding influenza risk, 59% were in danger control. Those in fear control were more likely to report influenza infection (p=.000). In the nonvaccinated, those in fear control were more likely to indicate not knowing where to get the vaccine (p=.016) and that it was unavailable (p=.027), and those in danger control believed they did not need it (p=.023). Zero critical values were more likely to indicate that no health provider recommended the shot (p=.002). Conclusions: Most perceived efficacy to be stronger than threat related to influenza; according to the EPPM, they are aware of their risk but recognize their ability to avert it. For those in danger control, messages should focus on increasing perceptions of severity and susceptibility to positively affect behavior change. For those in fear control, messages should focus on efficacy only. With a critical value of zero, no threat is induced, and a high-threat/high-efficacy approach should be taken. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

氟挥发对氟化物乳白玻璃瓶罐生产的影响

氟挥发对氟化物乳白玻璃瓶罐生产的影响陆德明，周俊梅，付希英（山东轻工业学院２５０１００）（山东德州玻璃厂２５３０１９）ＴｈｅＩｎｆｌｕｅｎｃｅｏｆＦｌｕｏｒｉｎｅＶｏｌａｔｉｌｉｚａｔｉｏｎｏｎＰｒｏｄｕｃｔｉｏｎｏｆＦｌｕｏｒｉｄｅｏｐａｌＧｌａｓ...     

轮胎用钢丝帘线及在山东省的发展

介绍了钢丝帘线子午线轮胎的优点和国际上的发展情况。生产钢丝帘线的典型工艺及山东省的生产近况。