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排序方式: 共有2456条查询结果,搜索用时 34 毫秒
1.
David Diaz Elisa Lopez-Dolado Sergio Haro Jorge Monserrat Carlos Martinez-Alonso Dimitrios Balomeros Agustín Albillos Melchor Alvarez-Mon 《International journal of molecular sciences》2021,22(2)
Our aim was to investigate the subset distribution and function of circulating monocytes, proinflammatory cytokine levels, gut barrier damage, and bacterial translocation in chronic spinal cord injury (SCI) patients. Thus, 56 SCI patients and 28 healthy donors were studied. The levels of circulating CD14+highCD16−, CD14+highCD16+, and CD14+lowCD16+ monocytes, membrane TLR2, TLR4, and TLR9, phagocytic activity, ROS generation, and intracytoplasmic TNF-α, IL-1, IL-6, and IL-10 after lipopolysaccharide (LPS) stimulation were analyzed by polychromatic flow cytometry. Serum TNF-α, IL-1, IL-6 and IL-10 levels were measured by Luminex and LPS-binding protein (LBP), intestinal fatty acid-binding protein (I-FABP) and zonulin by ELISA. SCI patients had normal monocyte counts and subset distribution. CD14+highCD16− and CD14+highCD16+ monocytes exhibited decreased TLR4, normal TLR2 and increased TLR9 expression. CD14+highCD16− monocytes had increased LPS-induced TNF-α but normal IL-1, IL-6, and IL-10 production. Monocytes exhibited defective phagocytosis but normal ROS production. Patients had enhanced serum TNF-α and IL-6 levels, normal IL-1 and IL-10 levels, and increased circulating LBP, I-FABP, and zonulin levels. Chronic SCI patients displayed impaired circulating monocyte function. These patients exhibited a systemic proinflammatory state characterized by enhanced serum TNF-α and IL-6 levels. These patients also had increased bacterial translocation and gut barrier damage. 相似文献
2.
Ramiro Palazn-García Ana María Benavente-Valdepeas 《International journal of molecular sciences》2021,22(9)
Botulism has been known for about three centuries, and since its discovery, botulinum toxin has been considered one of the most powerful toxins. However, throughout the 20th century, several medical applications have been discovered, among which the treatment of spasticity stands out. Botulinum toxin is the only pharmacological treatment recommended for spasticity of strokes and cerebral palsy. Although its use as an adjuvant treatment against spasticity in spinal cord injuries is not even approved, botulinum toxin is being used against such injuries. This article describes the advances that have been made throughout history leading to the therapeutic use of botulinum toxin and, in particular, its application to the treatment of spasticity in spinal cord injury. 相似文献
3.
AbstractData mining techniques have been successfully utilized in different applications of significant fields, including medical research. With the wealth of data available within the health-care systems, there is a lack of practical analysis tools to discover hidden relationships and trends in data. The complexity of medical data that is unfavorable for most models is a considerable challenge in prediction. The ability of a model to perform accurately and efficiently in disease diagnosis is extremely significant. Thus, the model must be selected to fit the data better, such that the learning from previous data is most efficient, and the diagnosis of the disease is highly accurate. This work is motivated by the limited number of regression analysis tools for multivariate counts in the literature. We propose two regression models for count data based on flexible distributions, namely, the multinomial Beta-Liouville and multinomial scaled Dirichlet, and evaluated the proposed models in the problem of disease diagnosis. The performance is evaluated based on the accuracy of the prediction which depends on the nature and complexity of the dataset. Our results show the efficiency of the two proposed regression models where the prediction performance of both models is competitive to other previously used regression models for count data and to the best results in the literature. 相似文献
4.
压水堆核电厂启动过程中,次级中子源为堆外源量程探测器提供本底计数率,避免测量盲区,确保反应堆安全启动。但次级中子源的引入会为核电厂带来较大的经济和环境负担,同时也需承受次级中子源破损等带来的风险。为此,可使用受辐照燃料组件的自发裂变中子源进行替代,即无源启动方式。通过研究堆外源量程探测器计数率的理论计算方法,并基于运行电厂测量数据进行分析验证,为源量程探测器计数率的理论预估提供了较为完善的理论方法流程。本文结果可为无源启动源量程探测器计数率分析提供支持,同时也可用于次级中子源装载量或布置位置的优化分析等。 相似文献
5.
6.
R. T. DeHoff 《Journal of microscopy》1985,138(2):143-151
Elements of surfaces that bound a phase (β) in a two phase mixture (α+β) may be classified as: (a) convex (++) if both principal curvatures are positive; (b) concave (? ?) if both are negative; and (c) saddle (+ ?) if one is positive and the other negative. This classification excludes the limiting cases for which one or both of the principal curvatures is zero. The traces of these surfaces that form the boundaries of the β areas on a representative two dimensional section may also be: (a) convex (+) if the local curvature is positive; or (b) concave (?) if it is negative. Line intercepts may be tabulated separately for intersections with convex (+) and concave (?) segments of boundary. This paper presents a derivation of fundamental stereological formulae that relate these counting measurements to three-dimensional geometric properties of the structure they sample. 相似文献
7.
Objective: Guided by the extended parallel process model (EPPM), the objective was to assess control processes dominant in influenza behavior decisions. Design: Cross-sectional survey. Results: Response rate was 31% (n=968). Regarding influenza risk, 59% were in danger control. Those in fear control were more likely to report influenza infection (p=.000). In the nonvaccinated, those in fear control were more likely to indicate not knowing where to get the vaccine (p=.016) and that it was unavailable (p=.027), and those in danger control believed they did not need it (p=.023). Zero critical values were more likely to indicate that no health provider recommended the shot (p=.002). Conclusions: Most perceived efficacy to be stronger than threat related to influenza; according to the EPPM, they are aware of their risk but recognize their ability to avert it. For those in danger control, messages should focus on increasing perceptions of severity and susceptibility to positively affect behavior change. For those in fear control, messages should focus on efficacy only. With a critical value of zero, no threat is induced, and a high-threat/high-efficacy approach should be taken. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
用SAS9.0中的响应曲面试验设计,研究了盐浓度、水分活度、发酵温度、发酵时间和糖浓度等环境因子对发酵香肠发酵过程中细菌总数变化的影响,建立科学的数学模型,此数学模型能够表达发酵香肠发酵过程中细菌总数的变化趋势。用建立的数学模型对发酵过程中的微生物进行了预测,结果可靠。细菌总数与实验测定数据进行比较,平均误差范围是-10.20%~8.43%。此数学模型为发酵香肠发酵过程的控制,提高发酵肉制品的安全性,缩短生产周期提供了依据,也是微生物预报的重要基础。 相似文献
9.
节能降耗提高矿山效益 总被引:1,自引:0,他引:1
节能降耗是每一个矿山提高经济效益的有效途径。我们采取提高球磨机处理能力,降低单耗;利用“分时计价”政策,采用“避峰作业”;使用新设备等措施节能降耗,提高矿山经济效益。 相似文献
10.
氟挥发对氟化物乳白玻璃瓶罐生产的影响陆德明,周俊梅,付希英(山东轻工业学院250100)(山东德州玻璃厂253019)TheInfluenceofFluorineVolatilizationonProductionofFluorideopalGlas... 相似文献