In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria

Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo.     

浅析火力发电厂汽水系统中内径管与外径管的设计选择

按照管道加工工艺的不同,管道可分为内径控制管和外径控制管。通过热轧工艺生产的外径控制无缝钢管,可满足火力发电厂汽水系统中绝大部分管道的使用要求。对于超(超)临界机组的主蒸汽和高温再热蒸汽管道采用的P91/P92材质的大口径厚壁无缝钢管,由于对材料性能和加工工艺有特殊要求,因此宜采用内径控制管。     

基于主体外部轮廓的照片分割算法

在实际应用中常常需要将人像从照片的背景中有效地分割出来，通常的做法是通过提取照片中人像各部分特征来实现分割，其缺陷是计算复杂度较大，分割效果受各种干扰因素影响很大。现提出了一种基于主体外部轮廓信息的照片分割算法，通过梯度锐化、边缘保护、临近像素点相似度比较来确定图像的边界，该算法对于具有相对均匀背景的照片具有较高的计算效率。     

浅析2020年前美军事战略重点的转变--从装备发展看美国军事战略重点可能的变化

美国21世纪前期的军事战略重点将是争夺外空优势，夺取制天权和制信息权。分析了美国夺取外空优势的原因，及其为夺取外空优势在国家政策、航天发展和技术准备等方面采取的措施。     

万家寨大坝外部变形控制网综述

结合万家寨水利枢纽大坝外部变形控制网测量项目 ,从控制网的布设、标点建造、观测、数据处理及成果分析等方面进行了介绍。实际观测结果说明 ,该控制网能够准确反映大坝运行状态 ,满足工程安全运行需要     

发动机扭矩与转速关系经验公式试验研究

在对发动机外特性曲线扭矩与转速实验数据分析的基础上，对原有的经验公式进行了分析、改进，提出了新的经验公式．由这一经验公式所计算的数值，在最大扭矩与最大功率点之间，可与实验数据拟合得很好．与原经验曲线相比，新经验曲线与实验曲线的离差可下降50％以上．     

Reconfiguration Aspects and a Reconfigurable Outer Block Interleaver for 3G Applications

Reconfiguration concept represents reconfigurable functionalities of the radio interface for mobile radio systems. Particularly for the physical layer, some possible reconfigurable architectures can be identified. We focus on outer interleaving for turbo codes, which can improve their performance in flat Rayleigh fading environment. The larger the number of columns in the outer interleaver, the better is the performance, but with the penalty of more complexity and delay. Furthermore, an incorrect choice of the number of columns can increase the bit and frame error rates. Therefore, it would be advantageous to reconfigure the outer interleaver in different operating environments with the optimum number of columns. Using two different data frame lengths, in this contribution simulation results are presented for the four possible outer block interleaver configurations specified for the 3GPP mobile standard in the case of flat Rayleigh fading channel. It is shown that different operating environments require an optimum number of columns in terms of bit error rate and frame error rate performance. Finally, frame fade duration is considered and the effect of the product of the Doppler frequency with the frame duration on the performance for the four different 3GPP outer block interleaver configurations is discussed. Costas Chaikalis was born in Athens, Greece, on March 7, 1973. He received the B.Sc. degree in electrical engineering in 1995 from Technological Educational Institute of Lamia, Greece. He also received the M.Sc. and Ph.D. degrees from Department of Electronics and Telecommunications, University of Bradford, Bradford, UK in 1999 and 2003, respectively. During his doctoral studies he worked as a Research Assistant for Mobile Virtual Center of Excellence (Mobile VCE), Terminals Group, UK. Since 2003, he is a lecturer in the Department of Electrical Engineering, Technological Educational Institute of Lamia, Greece. His research interests are in all areas of mobile communications but especially in forward error correction coding, reconfigurable (software radio) architectures, cross layer architectures and DSP applications.     

磨料高压水除鳞系统设计研究

磨料高压水除鳞系统取代酸洗线，原机械部分和磨料高压水部分都作了较大改进，才能保证除鳞彻底。     

油泵柱塞和轴承外套失效分析

对断裂的油泵柱塞、轴承外套从成分、组织、工艺等方面进行了检验分析。结果表明，柱塞首先断裂，断裂后的柱塞碎片卡住了轴承外套，使轴承外套过载脆断。而柱塞的断裂是由于热处理不当，造成淬火加热温度过高，使柱塞的显微组织出现粗大的针状马氏体，并引起淬火裂纹，导致柱塞的韧性下降，脆性增大，随着载荷作用和液压油的渗入，裂纹进一步扩展，当裂纹扩展笃柱塞有效载面积承受不了全部工作应力时，发生脆性断裂。     

东荣三矿冻结段井壁破坏原因简析

介绍了东荣三矿主井、副井、东风井三个井筒冻结段井壁的施工及破坏情况,并针对破坏的原因进行了分析,同时对冻结段的井壁结构型式提出了建议。