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1.
Understanding the mechanisms leading to the rise and dissemination of antimicrobial resistance (AMR) is crucially important for the preservation of power of antimicrobials and controlling infectious diseases. Measures to monitor and detect AMR, however, have been significantly delayed and introduced much later after the beginning of industrial production and consumption of antimicrobials. However, monitoring and detection of AMR is largely focused on bacterial pathogens, thus missing multiple key events which take place before the emergence and spread of AMR among the pathogens. In this regard, careful analysis of AMR development towards recently introduced antimicrobials may serve as a valuable example for the better understanding of mechanisms driving AMR evolution. Here, the example of evolution of tet(X), which confers resistance to the next-generation tetracyclines, is summarised and discussed. Initial mechanisms of resistance to these antimicrobials among pathogens were mostly via chromosomal mutations leading to the overexpression of efflux pumps. High-level resistance was achieved only after the acquisition of flavin-dependent monooxygenase-encoding genes from the environmental microbiota. These genes confer resistance to all tetracyclines, including the next-generation tetracyclines, and thus were termed tet(X). ISCR2 and IS26, as well as a variety of conjugative and mobilizable plasmids of different incompatibility groups, played an essential role in the acquisition of tet(X) genes from natural reservoirs and in further dissemination among bacterial commensals and pathogens. This process, which took place within the last decade, demonstrates how rapidly AMR evolution may progress, taking away some drugs of last resort from our arsenal. 相似文献
2.
《Ceramics International》2022,48(18):25808-25815
The harmless disposal of lead paste in the spent lead-acid batteries (LABs) remains an enormous challenge in traditional pyrometallurgical recycling. Here, we introduced a hydrometallurgical method for the recycling of the spent LABs’ waste to obtain the β-PbO as a novel zinc ion batteries (ZIBs) active material. The obtained β-PbO exhibits ultra-flat charge/discharge voltage platforms (0.21 mV/(mAh g?1)) and stable specific capacity. During the charge/discharge, the β-PbO spontaneously triggers the formation of (ZnSO4)[Zn(OH)2]3·5H2O (ZHS) micro-sheets as a surface passivation layer. Moreover, the ex-situ X-ray spectra reveal that the reversible phase transformation occurs between PbSO4 and Pb with the assistance of ZHS by adjusting the PH value on the electrode-electrolyte interface. The synergistic two-phase-reaction mechanism generates ultra-flat voltage platforms upon the charge/discharge. This “energy-saving and environment-friendly” recycling route eliminates the major source of emission of pollution particulates/gases compared to the traditional pyrometallurgical recycling, while at the same time replacing energy-consuming and environmentally detrimental processes of synthesis of current ZIBs cathodes. 相似文献
3.
A random placement of large-scale sensor network in the outdoor environment often causes low coverage.An area coverage optimization algorithm of mobile sensor network (MSN) based on virtual force perturbation and Cuckoo search (VF-CS) was proposed.Firstly,the virtual force of the sensor nodes within the Thiessen polygon was analyzed based on the partitioning of Voronoi diagram of the monitoring area.Secondly,the force of polygon vertices and neighbor nodes was taken as the perturbation factor for updating the node’s location of the Cuckoo search (CS).Finally,the VF-CS guided the node to move so as to achieve the optimal coverage.The simulation results demonstrate that the proposed algorithm has higher coverage and shorter average moving distance of nodes than the Voronoi diagram based algorithms in literatures. 相似文献
4.
面对三维空间移动机器人从起始点到终止点的最短路径问题,提出一种新型的边缘点树启发式搜索(TreeEP)算法,该方法将地图空间进行密度可调的三维离散化处理,根据障碍安全距离筛选出障碍物的可靠边缘点信息,再利用树扩散架构选出最能引导搜索方向的潜力点进行扩散搜索,最终得出最短路径。提出局部调整策略,得到改进的Tree-EP算法。实验结果表明,在带障碍复杂地形最短路径搜索应用中,提出的Tree-EP算法与已有方法相比,能找到更短的移动路径。 相似文献
5.
基于网络零售平台与制造商的合作广告实践,运用Stackelberg博弈理论研究了平台交叉销售效应及合作广告引导作用对O2O供应链合作广告决策的影响,并通过数值算例对参与合作广告计划前后渠道成员的决策变量均衡结果和利润进行对比分析,研究发现平台交叉销售效应是影响网络零售平台合作广告计划制定和实施的关键因素,只有当其达到一定水平时,制造商才拥有参与网络零售平台合作广告计划的资格;在一定条件时,合作广告计划能够实现制造商和网络零售平台利润的提升;当平台交叉销售效应较大时,网络零售平台获得的利润大于制造商。 相似文献
6.
LUO Jin-ling LIU Luo-ren 《广东电脑与电讯》2020,1(4):11-13
In view of the problems in the construction of characteristic professional groups in higher vocational colleges, the professional group of "intelligent manufacturing" is taken as the research object, and the "platform + module" suitable for the development
of the industry will be constructed according to the content of the vocational ability planning courses of the post group. The curriculum system establishes the framework of professional groups, and explores and forms a strategic study to optimize and integrate professional group resources. 相似文献
7.
This paper analyzes the problems existing in the teaching of data structure course, and puts forward the reform from the as-
pects of strengthening basic programming, visualized explanation of abstract theory, combination of C++, Java programming, ratio-
nal use of online platform, and stratification of exercises, aiming at improving students' practical ability, learning interest and self-
confidence. 相似文献
8.
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10.
为了提高夹心式压电驱动移动系统的机械输出性能,提出了一种U型预压力调节机构,并开展了预压力对夹心式压电驱动履带移动系统输出性能影响关系的实验研究。首先,针对U型预压力调节机构的安装对夹心式压电振子的振动特性影响关系开展了有限元仿真分析,发现U型预压力调节机构始终处在夹心式压电振子的两相工作模态振动节点位置;其次,开展了夹心式压电驱动履带移动系统的原理样机的预压力调节测试实验,确定了系统的最大输出牵引力及其所对应的最佳预压力;最后,在最佳预压力工作状态下,开展了原理样机的牵引力特性、越障性能以及模拟月壤环境下的运动特性实验。研究结果表明,在最佳预压力工作状态下,夹心式压电驱动履带移动系统的机械输出性能最佳,为其进一步在月面巡视器上的应用提供了技术支持和试验基础。 相似文献