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排序方式: 共有2405条查询结果,搜索用时 15 毫秒
1.
为了减轻因流动加速腐蚀(FAC)引起的锅炉结垢加速、汽水系统管道厚度减小甚至爆裂现象,对超临界机组发生流动加速腐蚀的机理及其主要影响因素进行了研究,并讨论了管壁内表面粗糙度、蒸汽含汽率、pH值、溶氧量对FAC的影响,以及温度与pH值、温度与流速、pH值与溶解氧量、溶解氧量与氢电导率等影响因素之间的相互作用关系,最后结合实际电厂的运行数据验证了分析结果。研究表明:减小工质流速、管壁粗糙度和氢电导率,增大给水的pH值和溶解氧含量可以使FAC的腐蚀速率减小,超临界加氧处理时pH值应在8.9~9.2之间,溶解氧量范围为45~100μg/L,氢电导率的期望值在0.1μS/cm以下。由于各影响因素之间的作用十分复杂,本文只给出了大致范围和趋势,并未给出准确数据。 相似文献
2.
Ashok Mahajan Naazneen Surti Pooja Koladiya 《Drug development and industrial pharmacy》2018,44(3):463-471
The aim of the present study was to improve the dissolution and flow properties of lurasidone hydrochloride (LH) by solid dispersion adsorbate (SDA) technique. Solid dispersions (SDs) of LH were prepared by fusion method using Poloxamer P188. The melt dispersion was adsorbed onto the porous carrier Florite (calcium silicate). A 32 factorial design was employed to quantify the effect of two independent variables, namely ratio of carrier (Poloxamer 188) and LH in SD and ratio of adsorbent (Florite) to SD. SDA granules of LH were studied for flow properties and characterized using differential scanning calorimetry, scanning electron microscopy, and X-ray diffraction. Tablets of optimized composition of SDA granules (equivalent to 20?mg of drug) and plain tablets were prepared by direct compression method. The dissolution studies were carried out in Mcllvaine buffer (pH 3.8) as per USFDA guidelines and characterized for parameters such as percent dissolution efficiency, t50, and Q30. Tablets prepared from SDA granules showed almost four-fold increase in cumulative percentage drug release as compared to tablets prepared from plain LH. The value of dissolution efficiency was enhanced from 49.60% for plain tablets to 94.15% for SDA tablets. SDA granules did not show any change in drug release and X-ray diffraction pattern after storage at 40?°C/75% of RH for 3?months, which confirms that Florite prevented conversion of drug from amorphous form to crystalline form improving physical stability of the amorphous state of LH. 相似文献
3.
Kamran Zaheer 《Drug development and industrial pharmacy》2018,44(3):444-451
Food induced viscosity can delay disintegration and subsequent release of API from solid dosage form which may lead to severe reduction in the bioavailability of BCS type III compounds. Formulations of such tablets need to be optimized in view of this postprandial viscosity factor. In this study, three super disintegrants, croscarmellose sodium (CCS), cross-linked polyvinylpolypyrrolidone (CPD), and sodium starch glycolate (SSG) were assessed for their efficiency under simulated fed state. Tablets containing these disintegrants were compressed at 10 and 30?KN, while taking lactose as a soluble filler. In addition to other compendial tests, disintegration force of these formulations was measured by texture analysis. Comparison of parameters derived from force – time curves revealed a direct relation of maximum disintegration force (Fmax) and disintegration force development rate (DFDR) with compressional force in fasted state, whereas an inverse relationship of Fmax and DFDR with compressional force was observed in fed state. The gelling tendency of disintegrants influenced the rate of release of API in simulated fed and fasted states when compressional force was changed. These observations recommend the evaluation of formulations in simulated fed state, in the development stage, with an objective of minimizing the negative impact of food induced viscosity on disintegration. Use of disintegrants that act without gelling or can counteract the effect of gelling is recommended for tablet formulations with reduced disintegration time (DT) and mean dissolution time (MDT) in fed state, respectively. 相似文献
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Cellulose dissolved in ionic liquid (1‐(carboxymethyl)pyridinium chloride)/water (60/40 w/w) mixture is regenerated in various non‐solvents, namely water, ethanol, methanol and acetone, to gain more insight into the contribution of non‐solvent medium to the morphology of regenerated cellulose. To this end, the initial and regenerated celluloses were characterized with respect to crystallinity, thermal stability, chemical structure and surface morphology using wide‐angle X‐ray diffraction, thermogravimetric analysis, Fourier transform infrared spectroscopy and scanning electron microscopy. According to the results, regardless of non‐solvent type, all regenerated samples have the same chemical structure and lower crystallinity in comparison to the initial cellulose, making them a promising candidate for efficient biofuel production based on enzymatic hydrolysis of cellulose. The reduction in crystallinity of regenerated samples is explained based on the potential of the non‐solvent to break the hydrogen bonds between cellulose chains and ionic liquid molecules as well as the affinity of water and non‐solvent which can be evaluated based on Hansen solubility parameter. The latter also determines the phase‐separation mechanism during the regeneration process, which in turn affects surface morphology of the regenerated cellulose. The pivotal effect of regenerated cellulose crystallinity on its thermal stability is also demonstrated. Regenerated cellulose with lower crystallinity is more susceptible to molecular rearrangement during heating and hence exhibits enhanced thermal stability. © 2019 Society of Chemical Industry 相似文献
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在1400℃下,将平均尺寸φ15 mm?10 mm的石灰块投入CaO?SiO2?FeO及CaO?SiO2?FeO?P2O5两组渣系中,研究了静态条件下石灰在两组渣系中的溶解行为。结果表明,两组渣系在反应界面周围形成四个区域,即基体渣层、C2S渗透层、铁酸钙渗透层和石灰层。渗透层为石灰中的Ca2+与液渣中的Fe2+相互渗透所形成的一个多相共存区域,存在致密固相层影响石灰的溶解。渗透层中的铁酸钙层逐渐被C2S层取代,C2S层厚度不断增加最终溶解于液相渣中。5~60 s两组渣系石灰溶解速度相近,60~80 s含磷渣系石灰溶解速度显著加快。当渣中加入P2O5时,磷会固溶于C2S中形成C2S?C3P固溶体层,该层的形成会排挤FeO进入渣中,提高渣的渗透能力,加速石灰溶解。 相似文献
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Justin R. Hughey Justin M. Keen Ryan C. Bennett Sakae Obara James W. McGinity 《Drug development and industrial pharmacy》2015,41(8):1294-1301
While the use of amorphous solid dispersions to improve aqueous solubility is well documented, little consideration has traditionally been given to the finished dosage form. The objective of this study was to evaluate the dissolution performance of amorphous solid dispersions containing a dispersed superdisintegrant with binding properties. KinetiSol® dispersing was used to thermally process hypromellose acetate succinate-based compositions containing the drug substance nifedipine (NIF) and a highly compressible grade of low-substituted hydroxypropyl cellulose (New Binder Disintegrants; NBD-grade). Solid-state analysis demonstrated that compositions were rendered amorphous during processing. Tablets containing intra-dispersion NBD were found to exhibit non-sink dissolution performance similar to milled intermediate, demonstrating excellent disintegration characteristics. Conversely, tablets without intra-dispersion NBD were found to release significantly less NIF during dissolution analysis due to particle agglomeration. It was determined that compressibility and particle wetting increased as the level of intra-dispersion NBD increased. 相似文献
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