药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

Which states and cities protect residents from water shutoffs in the COVID-19 pandemic?

Many U.S. states and cities have imposed water disconnection moratoriums during the COVID-19 pandemic. Using logistic and Cox Proportional-Hazards models, we assess factors that differentiate which governments imposed moratoriums. States, which have economic regulation of private water utilities, were more likely to impose moratoriums, and those with higher COVID-19 case rates imposed moratoriums earlier. States with unified Republican Control and cities with more 2016 Trump voters were less likely to impose moratoriums on water disconnection. Cities in states without statewide moratoriums, were more likely to impose moratoriums if they had higher income, more minority residents, and more income inequality.     

Engineering accidents in society: A comparison of Chinese and American railway accident investigation

Based on the investigation reports for two major railway accidents in China and the USA, as well as the analysis of related systems, this paper compares the differences between Chinese and American railway accident investigation modes along different dimensions. The four aspects attended to are the investigation purpose, institutional basis, scope and process, and type of conclusion. The results reveal the role of social factors in shaping the investigation pattern of engineering accidents, and show engineering accidents can serve as a window to understanding a society and the ways that learning from engineering accidents is a socially institutionalized process. A final discussion considers possible improvements that might be introduced into the Chinese mode of engineering accident investigation.     

A tree-structured crash surrogate measure for freeways

In this paper, we propose a novel methodology to define and estimate a surrogate measure. By imposing a hypothetical disturbance to the leading vehicle, the following vehicle’s action is represented as a probabilistic causal model. After that, a tree is built to describe the eight possible conflict types under the model. The surrogate measure, named Aggregated Crash Index (ACI), is thus proposed to measure the crash risk. This index reflects the accommodability of freeway traffic state to a traffic disturbance. We further apply this measure to evaluate the crash risks in a freeway section of Pacific Motorway, Australia. The results show that the proposed indicator outperforms the three traditional crash surrogate measures (i.e., Time to Collision, Proportion of Stopping Distance, and Crash Potential Index) in representing rear-end crash risks. The applications of this measure are also discussed.     

美国海军装备计量标识管理介绍

介绍了美国海军装备计量标识管理制度。对美国海军装备计量技术活动、计量和校准计划、计量需求目录内容进行了说明,并介绍了计量标识管理的一些规定,详细说明了美海军计量标识的种类、用法、样式、注意事项等情况。     

Competitiveness of shallow water hydrocarbon development projects in Mexico after 2015 actualization of fiscal reforms: Economic benchmark of new production sharing agreement versus typical U.S. federal lease terms

Development of Mexican hydrocarbon reservoirs by foreign operators has become possible under Mexico's new Hydrocarbon Law, effective as per January 2015. Our study compares the economic returns of shallow water fields in the Gulf of Mexico applying the royalty and taxes due under the fiscal regimes of the U.S. and Mexico. The net present value (NPV) of the base case scenario is US$1.4 billion, assuming standard development and production cost (opex, capex), 10% discount rate accounting for the cost of capital and revenues computed using a reference oil price of $75/bbl. The impact on NPV of oil price volatility is accounted for in a sensitivity analysis. The split of the NPV of shallow water hydrocarbon assets between the two contractual parties, contractor and government, in Mexico and the U.S. is hugely different. Our base case shows that for similar field assets, Mexico's production sharing agreement allocates about $1,150 million to the government and $191 million to the contractor, while under U.S. license conditions the government take is about $700 million and contractor take is $553 million. The current production sharing agreement leaves some marginal shallow water fields in Mexico undeveloped for reasons detailed and quantified in our study.     

Making connections and building bridges: improving the bi-national planning process

Creating a continental transportation system that supports the efficient movement of goods between Canada and the United States is essential to the economies of both countries. However, 25 years after the passage of the Canada–US Free Trade Act and many agreements and accords later, poor connectivity, congestion and delays still plague many transborder corridors. Recent attempts to improve this situation involving several proposed new bridge projects have either been halted or significantly delayed over the last decade. This paper will review and critically examine the bi-national planning process that has been followed in an attempt to build a new bridge across the Detroit River, known as the Detroit River International Crossing (DRIC) project.     

Atomic Afterimages

This article examines the recirculation of Robert Del Tredici's photographs of the Cold War nuclear weapons complex. Originally published in his groundbreaking book, At Work in the Fields of the Bomb (1987), a number of Del Tredici's photographs have been republished in a series of post‐Cold War US Department of Energy reports. The article examines the post‐Cold War circulation of Del Tredici's images in these official government reports and analyzes shifts in their meaning across different historical periods. Ultimately, this paper raises questions about the critical stance of Del Tredici's photographs as they are republished in government reports and examines ways in which the meaning of his photographs responds to both Cold War and post‐Cold War contexts.     

I like it because I said that I like it: Evaluative conditioning effects can be based on stimulus-response learning.

Evaluative conditioning (EC) effects are often assumed to be based on a learned mental link between the CS (conditioned stimulus) and the US (unconditioned stimulus). We demonstrate that this link is not the only one that can underlie EC effects, but that if evaluative responses are actually given during the learning phase also a direct link between the CS and an evaluative response—a CS-ER link—can be learned and lead to EC effects. In Experiment 1, CSs were paired with USs and participants were asked to evaluate the pairs during the conditioning phase. Resulting EC effects were unaffected by a later revaluation of the USs, suggesting that these EC effects can be attributed to CS-ER learning rather than to CS-US learning. Experiment 2 replicated Experiment 1 with the difference that no evaluative responses were given during the learning phase. EC effects in this study were influenced by US revaluation, suggesting that these EC effects are mainly based on CS-US learning. In Experiment 3, it was shown that EC effects can be found even if the USs are entirely removed from the procedure and the CSs are only paired with enforced evaluative responses. Together the experiments show that the valence of a stimulus can change because of a contingency with an evaluative response. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Architecture Takes Time

Though condensed between the stages of design and completion, the conventional process of designing a building is time consuming, involving various stakeholders, planning processes and a wide team of consultants and contractors. What happens, though, if the time period of an architect's involvement is expanded? How might a more process-orientated approach shift the role of the architect? Tobias Armborst, Daniel D'Oca and Georgeen Theodore , principals of Interboro Partners in New York, describe how they have developed projects that have sought opportunities in expanding the timescale and remit of traditional practice.