玉米须黄酮微胶囊制备条件的研究

本实验的目的是通过制备玉米须黄酮的微胶囊,以提高玉米须黄酮的稳定性。实验以β-环糊精为壁材,研究了研磨法制备微胶囊工艺中不同因素对玉米须黄酮微胶囊化包埋率及产率的影响。研究结果表明,采用研磨法制备微胶囊,芯材与壁材的最佳配比为1:14,研磨最佳时间为35min,β-环糊精的最佳浓度为10%,微胶囊化的最佳温度为48℃。在此条件下,产品微胶囊化效率达到85.6%。     

β-Cyclodextrin/Triclosan Complex-Grafted Methacrylated Glycol Chitosan Hydorgel by Photocrosslinking via Visible Light Irradiation for a Tissue Bio-Adhesive

Accelerating wound healing with minimized bacterial infection has become a topic of interest in the development of the new generation of tissue bio-adhesives. In this study, we fabricated a hydrogel system (MGC-g-CD-ic-TCS) consisting of triclosan (TCS)-complexed beta-cyclodextrin (β-CD)-conjugated methacrylated glycol chitosan (MGC) as an antibacterial tissue adhesive. Proton nuclear magnetic resonance (¹H NMR) and differential scanning calorimetry (DSC) results showed the inclusion complex formation between MGC-g-CD and TCS. The increase of storage modulus (G’) of MGC-g-CD-ic-TCS after visible light irradiation for 200 s indicated its hydrogelation. The swollen hydrogel in aqueous solution resulted in two release behaviors of an initial burst and sustained release. Importantly, in vitro and in vivo results indicated that MGC-g-CD-ic-TCS inhibited bacterial infection and improved wound healing, suggesting its high potential application as an antibacterial tissue bio-adhesive.     

羟丙基-β-环糊精的合成

对羟丙基-β-环糊精（注射级）的合成路线进行了优化,结果显示,优化后的工艺成本较低,适用于工业生产,收率可达100%,平均取代度控制在4.0～5.0,β-环糊精残留控制在≤0.3%。     

乳化剂抑制鲜湿面老化机理的研究

本研究探讨两种不同乳化剂的添加量和储藏时间对鲜湿面淀粉热力学行为产生的影响。利用差示量热扫描(DSC)、Avrami方程和Hyper Chem软件对分别添加硬脂酰乳酸钠(SSL),β-环糊精(β-CD)两种乳化剂的鲜湿面老化动力学方程与分子结构模型进行分析。结果表明抑制老化的最佳添加量为:SSL 0.2%,β-CD 0.10%。乳化剂/鲜湿面体系较空白组具有更加有序致密的结构;乳化剂/鲜湿面体系的老化焓均小于空白组;SSL/鲜湿面体系成核方式(n1),结晶速率常数(k1)与β-CD/鲜湿面体系成核方式(n2),结晶速率常数(k2)的变化范围为:n1=0.743~0.759、k1=0.328~0.353、n2=0.748~0.785、k2=0.321~0.356,且乳化剂/鲜湿面的成核方式均不断趋近于自发成核,结晶速率常数均小于空白组;通过Hyperchem软件模拟发现乳化剂能打开并插入淀粉老化过程中形成的双螺旋结构中,牵制直链淀粉并形成无定形区。结果说明添加乳化剂能延缓鲜湿面淀粉的老化,为延长鲜湿面的货架期提供参考。     

B.t.β-环糊精包合物的制备及其杀虫效果

制备出苏云金芽孢杆菌（B．t．）β-环糊精包合物，并对包合物进行了差热分析，证明B．t．原粉被β-环糊精包合。室内生物活性测定结果表明，当B．t．原粉与β-环糊精质量比为0．5：2时，包合物对棉铃虫2龄幼虫的杀虫活性最高，确定包合物中B．t．原粉与肛环糊精的最佳质量比为0．5：2。盆栽药效试验结果表明，当B．t．原粉制成环糊精包合物后，与B．t．原粉和B．t．制剂相比，对小菜蛾的防效明显提高。药剂处理后1、3、7d，B．t．环糊精包合物对小菜蛾的防效分别为41．67％、61．54％和60．00％，而B．t．原粉和制剂的防效分别为23．61％、38．46％、32．00％和31．94％、52．31％、46．00％。     

基于水凝胶聚合物波导传感器检测盐酸吖啶黄

多功能化是光纤化学传感器的重要发展方向。为实现该目标,首先通过激光诱导波导自形成技术制备了一种光纤–水凝胶聚合物波导–光纤传感结构,并在水凝胶聚合物波导探针中成功地掺杂了纳米金颗粒。在该结构中,波导与光纤同轴无缝相连,保证了探测光和信号光的高效利用。掺金后的聚合物波导具有丰富的光谱探测能力,利用该波导探针成功实现了对盐酸吖啶黄的吸收、荧光以及拉曼光谱的检测,扩大了波导传感器的应用范围。     

茉莉精油β-环糊精包合物的结构指征

对茉莉精油 β 环糊精包合物进行鉴别。分别采用X 射线衍射线、差示扫描量热法及扫描电镜对包合物的晶体结构、焓变及形状进行分析研究。X 射线衍射法及差示扫描量热法均显示 :茉莉精油 β 环糊精包合物与两者的混合物以及 β 环糊精的本身截然不同 ;扫描电镜显示出包合物结构完整 ,颗粒大小均匀。茉莉精油被 β 环糊精包合后 ,呈现出与茉莉精油及 β 环糊精均不相同的新的物相特征。     

Beta-cyclodextrin adsorbents to remove water pollutants—a commentary

Beta-cyclodextrin-based adsorbent is a promising adsorbent because it has unique characteristics and able to form host-guest complexes with various organic compounds. Adsorption using beta-cyclodextrin-based adsorbent has continuously improved by various preparation strategies and crosslinking agents. This commentary aims to highlight the preparation strategies, properties, and adsorption mechanisms of beta-cyclodextrin-based adsorbents. The adsorbents can be generally classified according to the preparation methods and display high adsorption capacity especially for dyes. Particularly, composite/nanocomposite beta-cyclodextrin-based adsorbents exhibit outstanding adsorption capacity even though the surface area is lower than that of porous and magnetic beta-cyclodextrin-based adsorbents. The beta-cyclodextrin/chitosan functionalized graphene oxide hydrogel with specific surface of 17.6 m²·g^–1 yields an extraordinarily maximum adsorption capacity of 1499 mg·g^–1 methylene blue, while beta-cyclodextrin/chitosan modified with iron(II, III) oxide nanoparticles displays a much greater maximum adsorption capacity at 2780 mg·g^–1. The hydrophobic interaction, functional groups, hydrogen bonding, and electrostatic interaction govern the adsorption to a greater capacity. Although this commentary is not exhaustive, the preparation strategies and illustrated mechanisms provide useful insights into the adsorbent–adsorbate interactions, cost-effective analysis, challenges, and future directions of beta-cyclodextrin-based adsorbents in wastewater treatment.     

Screening of sugars and cyclodextrins as carriers in montelukast dry powder inhalers processed by spray freeze drying

The purpose of this study was to develop a site targeting montelukast sodium (MTK) microparticles as a respiratory drug delivery system using the spray freeze drying (SFD) process. A range of sugars and cyclodextrins (CDs) were screened as carrier in order to find compatible excipients for the preparation of dry powder inhalers (DPIs). The physical characteristics of collected powders were studied by scanning electron microscopy (SEM), laser light scattering, differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The aerodynamic behavior of the particles was also assessed using twin stage impinge (TSI). In the presence of simple sugars as carriers, highly porous particles in irregular shapes were produced. The use of CDs resulted in the formation of spherical particles with high porosity. Among all carriers that were used during the preparation of powders, raffinose had the best aerodynamic behavior with a fine particle fraction (FPF) of 60 % in sugar groups, while the lowest FPF was related to trehalose as carrier. Powders containing CDs mostly showed proper aerodynamic behavior, especially in formulations containing alfa-cyclodextrin (A-CD), beta-cyclodextrin (β-CD), and highly branched cyclic dextrin (HBCD). Overall, data indicated that the CDs were excellent excipients for use with MTK for respiratory drug delivery.