Advances in Transgenic Mouse Models to Study Infections by Human Pathogenic Viruses

Medical research is changing into direction of precision therapy, thus, sophisticated preclinical models are urgently needed. In human pathogenic virus research, the major technical hurdle is not only to translate discoveries from animals to treatments of humans, but also to overcome the problem of interspecies differences with regard to productive infections and comparable disease development. Transgenic mice provide a basis for research of disease pathogenesis after infection with human-specific viruses. Today, humanized mice can be found at the very heart of this forefront of medical research allowing for recapitulation of disease pathogenesis and drug mechanisms in humans. This review discusses progress in the development and use of transgenic mice for the study of virus-induced human diseases towards identification of new drug innovations to treat and control human pathogenic infectious diseases.     

俄罗斯地铁站地下空间人性化设计

通过对莫斯科地铁站地下空间设计的分析,总结了其人性化设计的经验,旨在对我国地铁站地下空间设计有一定的借鉴作用。     

Expression of Human DNAJ (Heat Shock Protein-40) B3 in Humanized UDP-glucuronosyltransferase 1 Mice

The human DNAJB3 gene encodes a DNAJ (Heat shock protein 40; Hsp40) homolog, subfamily B, member 3 chaperone protein (DNAJB3), which can be down-regulated in disease conditions, as observed in decreased expression of DNAJB3 mRNA in peripheral blood mononuclear cells (PBMC) of obese patients. Recently, humanized UDP-glucuronosyltransferase (UGT) 1 mice (hUGT1 mice) were developed, in which the introduced human UGT1 gene contained a gene encoding human DNAJB3. In the present study, we analyzed the expression of human DNAJB3 mRNA in hUGT1 mice. Among the examined tissues, the testis had the highest expression of human DNAJB3 mRNA, while the lowest expression was observed in the liver. We found that the pattern of tissue-specific expression of mouse Dnajb3 in hUGT1 mice was very similar to that of human DNAJB3. We further demonstrated that the expression of human DNAJB3 in the liver was significantly reduced in high-fat-diet-fed hUGT1 mice compared to the expression level in the control mice, indicating that the expression of human DNAJB3 in hUGT1 mice could be similarly regulated in disease conditions such as obesity. Humanized UGT1 mice might therefore be useful to investigate the physiological role of human DNAJB3 in vivo.     

基于循证的寒地综合医院的人性化设计研究

鉴于众多国家正在普遍使用循证方式去量化体验指数和指导设计,我国也正开始逐步应用循证设计理论,尝试将研究参与到设计的前期循证和实验及使用后评价的工作中去,文中将处于北方寒冷地域的综合医院为研究对象,对其进行循证评价分析指导设计,通过参照用后评价指标,印证循证指导的人性化设计策略的有效性。     

城市养老院建筑的人性化设计

老年人是一群比较特殊的群体，城市疗养院要想为老年人提供更好的生活，在建筑设计方面应该尽可能地为老人提供方便，对老人衰退的感觉机能和生理机能加以综合考虑，从而实现最为人性化的设计，为老年群体的起居生活提供便利。     

交通设施的人性化设计分析

目前，各行各业都普遍运用到了人性化理念。本文主要对我国交通设施的人性化设计进行了分析与研究，同时针对一些问题总结出了相应的处理措施。     

人性化的城市交通空间规划设计实践

长期以来,我国城市交通围绕小汽车为核心发展,对行人、自行车、公共交通等方面的关注不够,交通系统的人性化亟需完善和提升。尽管近年来随着绿色交通的兴起,交通系统的人性化逐渐被重视和关注,但人性化的交通体系规划建设仍然面临很大的挑战。本文从交通基础设施建设、交通使用者、城市管理者三个方面分析了人性化交通系统发展面临的困境,从宏观、中观、微观三个层面提出了构建人性化交通空间的对策和建议。     

谈医院健康体检中心设计心得

从医院健康体检中心的规划、流程与布局、室内设计与人性化等几个方面加以阐述,将工作中积累的一些经验与各位同行分享.     

医疗环境中的色彩设计

分析了色彩的作用,包括色彩的生理作用与心理作用以及色彩的标识作用,归纳了色彩的应用原则,提出了医疗环境中室内空间和环境小品的色彩设计方法,以期指导医疗环境设计。