Research on the relationship between cephalosporin structure,solution clarity,and rubber closure compatibility using volatile components profile of butyl rubber closures

Objective: Establish an effective experimental strategy to determine the compatibility of rubber closures for drugs.

Significance: Various types of rubber closures with different compositions are available for drug packaging. Many additives of rubber closures can be released from rubber closures and may affect the quality of drugs and pose a risk to human health. In this study, we aimed to determine the relationship between cephalosporin structure, solution clarity, and rubber closure compatibility using volatile components profile of butyl rubber closures.

Methods: Two opposite polarity gas chromatography (GC) systems and GC-mass spectrometry (MS) were used to achieve rapid qualitative determination of the main volatile components in rubber closures. Simulated adsorption experiment was performed to investigate the adsorption of main volatile components in rubber closures by cephalosporins with different side chain structures, and to determine the effects of adsorption on solution clarity.

Results: A volatile components screening library of rubber closures was established and the structures of some volatile component were confirmed. The specific adsorption of the structure of cephalosporins on volatile components from rubber closures was studied.

Conclusion: Based on the results of this study, rubber closures with good compatibility for cephalosporins with different side chain structures can be selected rapidly. This experimental strategy not only facilitates the screening of suitable rubber closures more effectively, but also enables the quick determination of volatile components adsorbed by drugs.     

基于凸闭包集的不规则三角网算法研究与实现

不规则三角网是影响土石方量计算的关键问题之一，虽然目前已有大量研究人员对Delaunay三角网进行优化，但仍然缺少对三角网生成速率和计算精度的综合研究。针对此问题，基于VB.NET平台的点、边以及三角形的结构化数据结构设计快速生成凸闭包集形成Delaunay三角网，通过四边形空圆特性以及对角线最短原则对构网结果进行检验和优化。试验计算表明，该算法的计算结果与经典DTM法、方格网法的土方量计算相对误差均在0.30%以内。该方法不仅具有较高的组网效率，并能保持较好的计算精度。     

Enriching Context Information for Entity Linking with Web Data

Journal of Computer Science and Technology - Entity linking (EL) is the task of determining the identity of textual entity mentions given a predefined knowledge base (KB). Plenty of existing...     

复杂膨胀性围岩条件下交岔点支护技术研究

针对复杂膨胀性围岩条件下交岔点高应力集中区围岩稳定性控制和支护技术难题，通过对交岔点围岩变形表现形式、交岔点围岩变形机理的研究分析，提出了交岔点支护难点及重点。基于围岩控制理论分析，提出了“有限让压的柔性支护+全断面封闭抗压的刚性支护技术”，前期柔性支护采用“高强、高预应力锚杆+锚索+喷浆”联合支护有限度控制围岩变形，允许围岩在可控范围内释放围岩应力|后期通过架设异形支架与支撑架组成的联合支护体并喷射混凝土对交岔点围岩进行全断面封闭抗压支护，有效控制巷道交岔点围岩的变形。确保了交岔点围岩变形的整体可控性、稳定性，达到了预期支护效果。     

Estimation of fatigue crack growth behavior for small-sized C-shaped inside edge-notched tension (CIET) specimen using compliance technique

Being restricted by the relative larger size requirement, traditional and standard fracture specimens are not applicable for the estimation of fatigue crack growth behavior of some very finite-sized components and precious materials. This study develops a small-sized C-shaped inside edge-notched tension (CIET) specimen which has an advantage of specimen minimization and a wide range of adaptability. A systemic compliance technique for estimating fatigue crack growth behavior of CIET specimen has been successfully constructed and experimentally verified. Groups of fatigue crack propagation rate tests of both CIET specimen and CT specimen for 5083-H112 aluminum alloy were carried out. The resulted da/dN ∼ ΔK curves are heavy affected by specimen configuration and load ratio, and the difference between these da/dN ∼ ΔK curves has been successfully removed by introducing the correction of plasticity-induced crack closure effect. Consequently, the feasibility of CIET specimen for estimating fatigue crack propagation behavior for small-sized components and precious materials has been evidently confirmed.     

Data-driven modeling of mesoscale solids stress closures for filtered two-fluid model in gas–particle flows

This study performs data-driven modeling of mesoscale solids stress closures for filtered two-fluid model (fTFM) in gas–particle flows via an artificial neural network (ANN) based machine learning method. The data used for developing the ANN-based predictive data-driven modeling framework is systematically filtered from fine-grid simulations. The loss function optimization result reveals that coupling two loss functions promotes more accurate predictions of the mesoscale solids stresses than using a single loss function. Further comprehensive assessments of closure markers demonstrate a systematic dependence of the mesoscale solids stresses on the filtered particle velocity and its gradient as additional anisotropic markers, instead of using the conventional isotropic filtered rate of solid phase deformation as a closure marker. An optimal three-marker mesoscale closure is thus proposed. Comparative analysis of the conventional filtered model and present three-marker model shows that the data-driven model can substantially enhance the prediction accuracy.     

建筑类型学在建筑设计教学中的运用

当今的建筑教育仍遵从功能主义的指导思想，忽视对学生进行形式创作方法与技巧的培养，已明显滞后于当今建筑发展的要求。本文基于建筑类型学在建筑设计中厂泛的影响以及其兼具认识论与方法论基础的特点，提出在建筑设计教学中采用类型学的方法对学生进行系统、科学的形式教育。     

主跨602m的杨浦大桥主桥安装施工技术

杨浦大桥主桥结构形式为双塔双索面全漂浮体系迭合梁斜拉桥，主跨６０２ｍ，其钢梁安装，斜索张拉和桥面合龙技术是整个工程的关键。     

结构优化的APDL语言面向对象程序设计

引入面向对象技术机制，将结构优化问题运用类，对象，成员等概念进行数据抽象处理，在此基础上，编制APDL程序模块进行求解，算例表明，本文思想准确可行。     

试析"萨伏伊别墅"中的非理性因素

萨伏伊别墅集中表现了勒·柯布西耶早期的建筑思想和理想.它所体现的机器美学一直被认为是理性主义的代表.本文试图从支撑体系、内部空间、立面、环境中来找出其非理性因素,试图呈现该建筑的另一面.