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Paola Leonor Quan Marina Sabat-Bresc Yanru Guo Margarita Martín Gabriel Gastaminza 《International journal of molecular sciences》2021,22(9)
Recent research on mast cell biology has turned its focus on MRGPRX2, a new member of the Mas-related G protein-coupled subfamily of receptors (Mrgprs), originally described in nociceptive neurons of the dorsal root ganglia. MRGPRX2, a member of this group, is present not only in neurons but also in mast cells (MCs), specifically, and potentially in other cells of the immune system, such as basophils and eosinophils. As emerging new functions for this receptor are studied, a variety of both natural and pharmacologic ligands are being uncovered, linked to the ability to induce receptor-mediated MC activation and degranulation. The diversity of these ligands, characterized in their human, mice, or rat homologues, seems to match that of the receptor’s interactions. Natural ligands include host defense peptides, basic molecules, and key neuropeptides such as substance P and vasointestinal peptide (known for their role in the transmission of pain and itch) as well as eosinophil granule-derived proteins. Exogenous ligands include MC secretagogues such as compound 48/80 and mastoparan, a component of bee wasp venom, and several peptidergic drugs, among which are members of the quinolone family, neuromuscular blocking agents, morphine, and vancomycin. These discoveries shed light on its capacity as a multifaceted participant in naturally occurring responses within immunity and neural stimulus perception, as in responses at the center of immune pathology. In host defense, the mice Mrgprb2 has been proven to aid mast cells in the detection of peptidic molecules from bacteria and in the release of peptides with antimicrobial activities and other immune mediators. There are several potential actions described for it in tissue homeostasis and repair. In the realm of pathologic response, there is evidence to suggest that this receptor is also involved in chronic inflammation. Furthermore, MRGPRX2 has been linked to the pathophysiology of non-IgE-mediated immediate hypersensitivity drug reactions. Different studies have shown its possible role in other allergic diseases as well, such as asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. In this review, we sought to cover its function in physiologic processes and responses, as well as in allergic and nonallergic immune disease. 相似文献
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身份基加密(IBE)需要提供一种有效的成员撤销机制,然而,现有可撤销成员的IBE方案存在密钥更新和加密运算量过大的问题,可能使执行该操作的设备成为系统的瓶颈。将完全子树方法和在线离线技术相结合,通过修改指数逆类型IBE的密钥生成和加密算法,提出了一种高效可撤销的身份基在线离线加密方案。方案利用完全子树方法生成更新钥,使得撤销用户无法获得更新钥,进而失去解密能力;利用在线离线技术,将大部分加密运算在离线阶段进行预处理,使得在线阶段仅执行少量简单计算即可生成密文。与相关知名方案相比,该方案不仅提高密钥生成中心的密钥更新的效率,而且极大减少了轻量级设备的在线加密工作量,适合于轻量级设备保护用户隐私信息。 相似文献
4.
针对货运车辆在配送调度过程中产生大量碳排放的问题,建立模型将多种影响碳排放量的因素协同优化。模型中考虑了不同载重量的异质车队,两个节点之间有多条道路的柔性路径,以及车辆重量随卸货而减少的动态负载等因素,以碳排放量、行驶时间和行驶路程为优化目标,并加入了节点需求时间窗、根据速度变化划分路段、交接和卸货时间的约束。提出了一种混合蚁群算法,利用蚁群算法信息素强度更新方式保持群体记忆性,利用粒子群算法的快速收敛特性增加计算效率。通过随机数值算例的仿真优化与对比分析,验证了算法和模型的有效性。 相似文献
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This paper presents a control design for the one‐phase Stefan problem under actuator delay via a backstepping method. The Stefan problem represents a liquid‐solid phase change phenomenon which describes the time evolution of a material's temperature profile and the interface position. The actuator delay is modeled by a first‐order hyperbolic partial differential equation (PDE), resulting in a cascaded transport‐diffusion PDE system defined on a time‐varying spatial domain described by an ordinary differential equation (ODE). Two nonlinear backstepping transformations are utilized for the control design. The setpoint restriction is given to guarantee a physical constraint on the proposed controller for the melting process. This constraint ensures the exponential convergence of the moving interface to a setpoint and the exponential stability of the temperature equilibrium profile and the delayed controller in the norm. Furthermore, robustness analysis with respect to the delay mismatch between the plant and the controller is studied, which provides analogous results to the exact compensation by restricting the control gain. 相似文献
6.
The airline industry is a representative industry with high cost and low profitability. Therefore, airlines should carefully plan their schedules to ensure that overall profit is maximized. We review the literature on airline planning and scheduling and focus on mathematical formulations and solution methodologies. Our research framework is anchored on three major problems in the airline scheduling, namely, fleet assignment, aircraft routing, and crew scheduling. General formulation, widely used solution approaches, and important extensions are presented for each problem and integrated problems. We conclude the review by identifying promising areas for further research. 相似文献
7.
在埋地管道研究工作中,关于其腐蚀的防护一直是研究的焦点问题,但现阶段常用的防护手段多为防腐层与阴极防护。为此,在文中主要对二者的保护措施展开了相应地阐述,并重点分析了2种保护手段存在的问题,旨在为后续的管道防腐研究提供相应的参考。 相似文献
8.
采用伪布尔模型和启发式算法来求解无容量设施选址问题。首先给出了问题的伪布尔(pseudo-Boolean)表示,然后基于Khumawala规则对问题进行预处理,最后提出两种启发式分支准则来求解问题。实验结果表明所提算法简单有效。 相似文献
9.
Tundong Liu Linjing Liu Jing Chen Hao Jiang Qiao Sun 《Journal of Modern Optics》2018,65(14):1680-1687
This paper introduces an evolutionary algorithm, Shuffled Frog Leaping Algorithm (SFLA), to solve the optimization problem in designing the multi-pumped Raman Fibre Amplifier (RFA). SFLA is a powerful optimizer tool because of its efficient mathematical expressions and global search capability. We utilize SFLA to determine the optimal pump wavelengths and pump powers by minimizing the gain ripple of RFA. To accelerate calculations, a terminal value optimization strategy (TVOS) is incorporated into the evolution of SFLA. This proposed strategy takes the terminal power values of pumps as the decision variables in optimization. Then, the optimal original power values of the pumps are obtained by solving the Power Coupled Equations once, without using the traditional method of repetitive guesses.The combination of SFLA and TVOS enhances the efficiency of optimization and accelerates calculation, while satisfying the design requirements of RFA.The simulation results show that nearly 65% of computational time has been saved compared with the traditional average power analysis. The 4-pumped C+L band of backward multi-pumped RFA with the average net gain of 0 dB, 1 dB and 2 dB are designed individually, where the gain ripple is less than 0.64 dB. The combination of SFLA and TVOS enhance the optimization efficiency and improve the performance of RFA with good gain profile. 相似文献
10.
论三峡水库“蓄清排浑”运用方式及其优化 总被引:1,自引:0,他引:1
泥沙问题是三峡工程的关键技术问题之一,在三峡工程论证和初步设计阶段提出水库采取"蓄清排浑"的运用方式,可以解决泥沙问题。2003年水库蓄水运用以来的实践表明,水库基本遵循了"蓄清排浑"调度运用原则,并根据上游来水来沙减少等新情况对水库运用方式进行了优化调整。本文系统分析了三峡水库"蓄清排浑"运行方式及其优化调整的利弊,包括提前5年实施175 m试验性蓄水、汛期水位动态变化、汛末提前蓄水等对水库淤积和坝下游河道演变的影响,提出了进一步优化水库调度方式,形成"蓄清排浑"运用的新模式,保持水库长期使用的建议,试图为三峡水库科学高效安全运用提供科技支撑。 相似文献