Pharmacological Evidence on Augmented Antiallodynia Following Systemic Co-Treatment with GlyT-1 and GlyT-2 Inhibitors in Rat Neuropathic Pain Model

The limited effect of current medications on neuropathic pain (NP) has initiated large efforts to develop effective treatments. Animal studies showed that glycine transporter (GlyT) inhibitors are promising analgesics in NP, though concerns regarding adverse effects were raised. We aimed to study NFPS and Org-25543, GlyT-1 and GlyT-2 inhibitors, respectively and their combination in rat mononeuropathic pain evoked by partial sciatic nerve ligation. Cerebrospinal fluid (CSF) glycine content was also determined by capillary electrophoresis. Subcutaneous (s.c.) 4 mg/kg NFPS or Org-25543 showed analgesia following acute administration (30–60 min). Small doses of each compound failed to produce antiallodynia up to 180 min after the acute administration. However, NFPS (1 mg/kg) produced antiallodynia after four days of treatment. Co-treatment with subanalgesic doses of NFPS (1 mg/kg) and Org-25543 (2 mg/kg) produced analgesia at 60 min and thereafter meanwhile increased significantly the CSF glycine content. This combination alleviated NP without affecting motor function. Test compounds failed to activate G-proteins in spinal cord. To the best of our knowledge for the first time we demonstrated augmented analgesia by combining GlyT-1 and 2 inhibitors. Increased CSF glycine content supports involvement of glycinergic system. Combining selective GlyT inhibitors or developing non-selective GlyT inhibitors might have therapeutic value in NP.     

The effect of feedstock and process conditions on the synthesis of high purity CNTs from aromatic hydrocarbons

High purity multi-walled carbon nanotubes were synthesized from aromatic hydrocarbons (benzene, toluene, xylene and trimethyl benzene) using ferrocene as the source of Fe catalyst. Screening studies of aromatic feeds at 675 °C, residence time of 14 s and Fe/C atom ratio of 1.07%, resulted in feedstock carbon conversion of 20-31%, CNT yield of 19.8-30.5%, and catalyst yield of 5.3-8.3 (g CNT/g catalyst). While the quality of the CNTs as determined by TGA, SEM, TEM and Raman spectroscopy, were high and comparable for different feedstocks; their carbon conversion, CNT yield and catalyst yield differed noticeably. A process optimization study for toluene feed showed that carbon conversion of more than 39%, CNT yield of 38.7% and catalyst yield of 18.3 can be achieved at temperature of 800 °C, Fe/C atom ratio of 0.47%, and residence time of 10-20 s.     

Input-parallel output-parallel configuration of boost half bridge DC-DC converter with control strategy

The concept of connecting two boost half bridge DC-DC converter modules in input-paral- lel output-parallel configuration is presented. The input-parallel-output-parallel （IPOP） converter consists of multiple boost half bridge （BHB） DC-DC converter modules which are connected in par- allel at the input and output side. This kind of converter is an attractive solution for high power ap- plications. The correlation between input current sharing （ICS） and output current sharing （OCS） of the IPOP converter basic modules is described. Two loop control strategies, consisting of input cur- rent loop and output voltage loop, have been developed to achieve equal ICS and OCS in this present work. The control strategy for the IPOP configuration of boost haft bridge DC-DC converter has been verified for different load conditions （half load and full load）, The IPOP system proposed here is comprising of two modules but it can be extended to three or more. The performance of the pro- posed system along with the control strategy is verified by simulation in MATLAB using Simpower tool. Finally the satisfactory simulation results are obtained.     

大规模MIMO系统下的低复杂度迫零预编码技术

针对大规模天线技术导致传统迫零(zero-forcing, ZF)预编码复杂度上升的问题,提出了一种低复杂度预编码技术。首先利用对称超松弛迭代(semi-iteration symmetric successive overrelaxation method, SSOR)技术优化信道矩阵求逆复杂度的问题;然后利用切比雪夫半迭代法(semi-iteration, SI)加速SSOR迭代(semi-iteration symmetric successive overrelaxation method, SI-SSOR)的收敛速度,使得ZF预编码可以快速的收敛。实验结果表明,SI-SSOR预编码在误码率和传输速率上都有非常好的性能。切比雪夫半迭代法加速的SSOR预编码技术通过2次迭代就可以近似达到传统ZF预编码性能的95%以上,同时利用相对于迫零预编码更少的计算资源,因此,SI-SSOR预编码技术可以作为无线通信抑制干扰的重要手段。     

Siting park-and-ride facilities using a multi-objective spatial optimization model

Park-and-ride services are an important component of many public transportation systems in the United States. Locating park-and-ride facilities is an essential step when planning for these services. In this research we focus on three major siting/modeling concerns that need to be addressed when siting park-and-ride facilities: covering as much potential demand as possible, locating park-and-ride facilities as close as possible to major roadways, and siting such facilities in the context of an existing system. Unfortunately, existing models do not enable each of these concerns to be simultaneously addressed. This paper presents a multi-objective spatial optimization model for integrating these considerations. This model is applied for siting park-and-ride facilities in Columbus, Ohio. Application results show the usefulness of the developed model in supporting transit planning in an urban region.     

Giant Anomalous Hall and Nernst Conductivities in Magnetic All-d Metal Heusler Alloys

All-d Heuslers are a category of novel compounds combining versatile functionalities such as caloric responses and spintronics with enhanced mechanical properties. Despite the promising transport properties (anomalous Hall (AHC) and anomalous Nernst (ANC) conductivities) shown in the conventional Co₂XY Heuslers with p-d hybridization, the all-d Heuslers with only d-d hybridization open a new horizon to search for new candidates with outstanding transport properties. In this work, the AHC and ANC are evaluated for thermodynamically stable ferro/ferri-magnetic all-d-metal regular Heusler compounds based on high-throughput first-principles calculations. It is observed that quite a few materials exhibit giant AHCs and ANCs, such as cubic Re₂TaMn with an AHC of 2011 S cm^-1, and tetragonal Pt₂CrRh with an AHC of 1966 S cm^-1 and an ANC of 7.50 A m^-1K^-1. Comprehensive analysis on the electronic structure reveals that the high AHC can be attributed to the occurrence of the Weyl nodes or gapped nodal lines in the neighborhood of the Fermi level. The correlations between such transport properties and the number of valence electrons are also thoroughly investigated, which provides a practical guidance to tailor AHC and ANC via chemical doping for transverse thermoelectric applications.     

Copper/copper oxide nanoparticles synthesis using Stachys lavandulifolia and its antibacterial activity

Nanoparticles of copper/cuprous oxide (Cu/Cu₂ O) were successfully synthesised by a green chemistry route. The synthesis process was carried out using an extract of Stachys lavandulifolia as both reducing and capping agents with a facile procedure. The nanoparticles were characterised by different techniques including X‐ray diffraction, indicating that the synthesised sample comprised both copper and cuprous oxide entity. The nanoparticles had a mean size of 80 nm and represented an impressive bactericidal effect on Pseudomonas aeruginosa.Inspec keywords: copper, copper compounds, nanoparticles, nanofabrication, nanomedicine, antibacterial activity, X‐ray diffractionOther keywords: nanoparticles synthesis, Stachys lavandulifolia, antibacterial activity, green chemistry route, reducing agents, capping agents, X‐ray diffraction, bactericidal effect, Pseudomonas aeruginosa, Cu‐Cu₂ O     

Senti‐CS: Building a lexical resource for sentiment analysis using subjective feature selection and normalized Chi‐Square‐based feature weight generation

Sentiment analysis involves the detection of sentiment content of text using natural language processing. Natural language processing is a very challenging task due to syntactic ambiguities, named entity recognition, use of slangs, jargons, sarcasm, abbreviations and contextual sensitivity. Sentiment analysis can be performed using supervised as well as unsupervised approaches. As the amount of data grows, unsupervised approaches become vital as they cut down on the learning time and the requirements for availability of a labelled dataset. Sentiment lexicons provide an easy application of unsupervised algorithms for text classification. SentiWordNet is a lexical resource widely employed by many researchers for sentiment analysis and polarity classification. However, the reported performance levels need improvement. The proposed research is focused on raising the performance of SentiWordNet3.0 by using it as a labelled corpus to build another sentiment lexicon, named Senti‐CS. The part of speech information, usage based ranks and sentiment scores are used to calculate Chi‐Square‐based feature weight for each unique subjective term/part‐of‐speech pair extracted from SentiWordNet3.0. This weight is then normalized in a range of ?1 to +1 using min–max normalization. Senti‐CS based sentiment analysis framework is presented and applied on a large dataset of 50000 movie reviews. These results are then compared with baseline SentiWordNet, Mutual Information and Information Gain techniques. State of the art comparison is performed for the Cornell movie review dataset. The analyses of results indicate that the proposed approach outperforms state‐of‐the‐art classifiers.     

A soft robotics nonlinear hybrid position/force control for tendon driven catheters

Minimally invasive steerable catheters, commonly implemented in cardiac ablation, are currently operated by interventionalists exposing them to X-ray radiation and requiring the dexterity for accurate steering. To conduct robot-assisted cardiac ablation, highly accurate stable control platform for precise force/position control on the moving tissue is required. This paper introduces hybrid force/position control strategy to apply a constant force to the cardiac tissue while tracking the desired trajectory. The position controller is based on a nonlinear model predictive tracking control satisfying the input constraints. Cosserat rod theory is incorporated for the distal shaft modeling of tendon-driven catheters, and the model is reformulated for controller design and stability proof. Lyapunov-based stability analysis is conducted. To apply the controller, the force-displacement mapping of the cardiac tissue is obtained through ex vivo experimental tests. The performance of the controller is evaluated, and the catheter is capable of regulating the force with the RMSE of 4.9 mN and tracking the position with the RMSE of 0.89 mm. The promising results verify the potential of the application of the introduced approach in real applications including in vitro and clinical cardiac ablation.