One-to-Many: Context-Oriented Code for Concurrent Error Detection

The paper deals with context-oriented codes for concurrent error detection. We consider a fault model for which, in the presence of a fault, the values on the circuit’s output are arbitrary. This model allows one to design an error detection code without analyzing sensitive parts or error cones in the synthesized circuit. Conventional coding schemes are based on a one-to-one mapping between an original output vector (information word) and a codeword. In this paper, we introduce a different approach, which we call one-to-many coding. In one-to-many code, each codeword comprises a predefined set of words. The functional unit is referred to as an encoder enabling each activation to map an information word to a different word. This flexible mapping system results in a lower implementation cost of the functional unit and its checker.     

Maternal N-Acetyl-Cysteine Prevents Neonatal Hypoxia-Induced Brain Injury in a Rat Model

Perinatal hypoxia is a major cause of infant brain damage, lifelong neurological disability, and infant mortality. N-Acetyl-Cysteine (NAC) is a powerful antioxidant that acts directly as a scavenger of free radicals. We hypothesized that maternal-antenatal and offspring-postnatal NAC can protect offspring brains from hypoxic brain damage.Sixty six newborn rats were randomized into four study groups. Group 1: Control (CON) received no hypoxic intervention. Group 2: Hypoxia (HYP)-received hypoxia protocol. Group 3: Hypoxia-NAC (HYP-NAC). received hypoxia protocol and treated with NAC following each hypoxia episode. Group 4: NAC Hypoxia (NAC-HYP) treated with NAC during pregnancy, pups subject to hypoxia protocol. Each group was evaluated for: neurological function (Righting reflex), serum proinflammatory IL-6 protein levels (ELISA), brain protein levels: NF-κB p65, neuronal nitric oxide synthase (nNOS), TNF-α, and IL-6 (Western blot) and neuronal apoptosis (histology evaluation with TUNEL stain). Hypoxia significantly increased pups brain protein levels compared to controls. NAC administration to dams or offspring demonstrated lower brain NF-κB p65, nNOS, TNF-α and IL-6 protein levels compared to hypoxia alone. Hypoxia significantly increased brain apoptosis as evidenced by higher grade of brain TUNEL reaction. NAC administration to dams or offspring significantly reduce this effect. Hypoxia induced acute sensorimotor dysfunction. NAC treatment to dams significantly attenuated hypoxia-induced acute sensorimotor dysfunction. Prophylactic NAC treatment of dams during pregnancy confers long-term protection to offspring with hypoxia associated brain injury, measured by several pathways of injury and correlated markers with pathology and behavior. This implies we may consider prophylactic NAC treatment for patients at risk for hypoxia during labor.     

Posterolateral approach. An alternative strategy in laparoscopic splenectomy

Laparoscopic splenectomy (LS) is effective and technically feasible for treating various hematological diseases, especially idiopathic thrombocytopenic purpura (ITP). An anterior approach to the vascular pedicle is usually described. However, in this approach to the splenic hilum, the dissection of the splenic artery is often difficult. A total of 13 patients with ITP underwent elective laparoscopic splenectomy. We utilized a laparoscopic posterolateral approach involving dissection of the suspensory ligaments at the lower pole, then dissection and division of the posterolateral attachments, followed by the dissection and ligation of all splenic branches near the splenic parenchyma. This procedure was completed in 11 of our 13 patients and converted to open surgery in the other two patients. Mean operative time was 3 h; mean postoperative stay was 3 days. No blood transfusion was required, and no complications were noted in the postoperative period. The posterolateral approach provides better visualization and control of branches of the splenic vein and artery in the splenic hilum. It also permits visualization and control of surgical hemorrhage through the operating ports.     

Adaptations for Wear Resistance and Damage Resilience: Micromechanics of Spider Cuticular “Tools”

In the absence of minerals as stiffening agents, insects and spiders often use metal‐ion cross‐linking of protein matrices in their fully organic load‐bearing “tools.” In this comparative study, the hierarchical fiber architecture, elemental distribution, and the micromechanical properties of the manganese‐ and calcium‐rich cuticle of the claws of the spider Cupiennius salei, and the Zn‐rich cuticle of the cheliceral fangs of the same animal are analyzed. By correlating experimental results to finite element analysis, functional microstructural and compositional adaptations are inferred leading to remarkable damage resilience and abrasion tolerance, respectively. The results further reveal that the incorporation of both zinc and manganese/calcium correlates well with increased biomaterial's stiffness and hardness. However, the abrasion‐resistance of the claw material cross‐linked by incorporation of Mn/Ca‐ions surpasses that of many other non‐mineralized biological counterparts and is comparable to that of the fang with more than triple Zn content. These biomaterial‐adaptation paradigms for enhanced wear‐resistance may serve as novel design principles for advanced, high‐performance, functional surfaces, and graded materials.     

Nurses’ reactions to alarms in a neonatal intensive care unit

Neonatal intensive care units (NICUs), like other intensive care units, are intended to provide immediate responses to any change in the patients condition. Patient-monitoring alarms and alarms from other medical equipment are very common in these units, and most alarms have no clinical significance. This study addresses the question of how alarms affect nurses actions by measuring the occurrence of alarms from different causes in a NICU, recording the nurses reactions, and analyzing the relationship between the alarms and the actions. The results show that nurses often do not respond directly to alarms, but, rather, use them as additional sources of information in their ongoing flow of actions. The probabilities for their responding to an alarm depend on the causes of the alarm, its duration, and the characteristics of the patient. These findings support the view that experienced nurses dynamically adjust their activities according to the information they receive from alarm systems and other sources, and that they combine their reactive actions with the periodic performance of routine tasks.     

Observed sibling interaction: Links with the marital and the mother–child relationship.

The study examines whether the link between the marital relationship and sibling interaction is direct or mediated by the mother–child relationship. Seventy-three same-sex sibling pairs aged 3 years 6 months to 8 years 6 months were observed during free play. Mothers completed questionnaires assessing marital functioning and their relationship with their 2 children. Results indicated that older siblings' negative behavior is linked with negative dimensions of the marital and the mother–child relationship, whereas younger siblings' negative behavior is linked with the mother–child and the differential mother–child relationship. Siblings' positive behavior, although linked with spacing, is not linked with positive dimensions of family interaction. Most important, the linkage between negative marital relations and older siblings' negative behavior was found to be mediated by maternal power assertion, thereby supporting the indirect model of negative family interaction. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On inference for threshold autoregressive models

We provide a complete Bayesian method for analyzing a threshold autoregressive (TAR) model when the order of the model is unknown. Our approach is based on a version (Godsill (2001)) of the reversible jump algorithm of Green (1995), and the method for estimating marginal likelihood from the Metropolis-Hasting algorithm by Chib and Jeliazkov (2001). We illustrate our results with simulated data and the Wolfe’s sunspot data set. This research is supported in part by NSF Grant SCREMS 0112219.