Active transport of nitrofurantoin across the mammary epithelium in vivo

Nitrofurantoin is a commonly used urinary tract antibiotic that has been found at high concentrations in human milk. In vivo studies in rats were carried out to determine the mechanism by which this drug crosses the mammary epithelium. Lactating rats were gavage-fed with nitrofurantoin, and their milk and plasma levels of the antibiotic were measured at intervals up to 8 hr. The average milk-to-plasma (M/P) ratio, calculated from the areas under the milk and plasma curves, respectively, was 23 compared with a ratio predicted to be about 0.3 on the basis of lipid partitioning and protein binding determinations. M/P ratios for two nitrofurantoin congeners were also calculated. The neutral compound furazolidone had a M/P ratio of about 1, as predicted, whereas the basic compound furaltadone had a M/P ratio of 3.49 compared with a predicted ratio of 1.4. These data suggest that nitrofurantoin and, to a lesser extent, furaltadone are actively transported across the mammary epithelium into milk.     

Fast and Compact 16 by 16 Cellular Neural Network Implementation

The paper presents a Cellular Neural Network implementation based on a high gain sigmoid operation. The required simplifications to the original theory are described that allow the use of high gain. With this design black and white images can be processed. The basic building blocks in a cell are described. A 16×16 cells network has been designed and processed with 1.2 micron CMOS technology. Measurement results which show the operation of the network are presented.     

A Micropower Interface ASIC for a Capacitive 3-Axis Micro-Accelerometer

In this paper, a micropower interface IC for a capacitive 3-axis micro-accelerometer implemented in a 0.13- BiCMOS process is presented. The sensor interface consists of a front-end that converts the acceleration signal to voltage, two algorithmic ADCs, two frequency references, and a voltage, current, and temperature reference circuit. Die area and power dissipation are reduced by using time-multiplexed sampling and varying duty cycles down to 0.3%. The chip with a 0.51 active area draws 62 from a 1.8 V supply while sampling temperature at 100 Hz, and four proof masses, each at 1.04 kHz. With a 4-g capacitive 3-axis accelerometer, the measured noise floors in the x-, y-, and z-directions are 482 , 639 , and 662 , respectively.     

A Web‐based and Group Learning Environment for Introductory Environmental Engineering

The use of computer‐based technology is becoming more prevalent in the classroom. As a part of an educational research project sponsored by the GE Foundation, strategies for augmenting a course, Introduction to Environmental Engineering (CE 280), were investigated including cross‐disciplinary experiences in teamwork, design, and the use of advanced teaching technologies such as the web. Interactive tools to assist student learning were developed and refined. Efforts have focused on developing an extensive website, web‐based quizzes and homework assignments, and tutorials. Base groups were used to provide both intellectual and emotional support to students. This paper summarizes the development of this course and the impact of rapid feedback on the progression of student understanding.     

A digital quadrature modulator with on-chip D/A converter

The first analog IF mixer stage of a transmitter can be replaced with this digital quadrature modulator. The modulator interpolates orthogonal input carriers by 16 and performs digital quadrature modulation at carrier frequencies f/sub s//4, -f/sub s//4,f/sub s//2 (f/sub s/ is the sampling frequency). A 12-b digital-to-analog (D/A) converter is integrated with the digital quadrature modulator. A segmented current source architecture is combined with a proper switching technique to reduce spurious components and to enhance dynamic performance. The digital quadrature modulator is designed to fulfill the spectral, phase, and EVM specifications of GSM, EDGE, and WCDMA base stations. The die area of the chip is 27.09 mm/sup 2/ (0.35-/spl mu/m CMOS technology) and the total power consumption is 1.02 W with 2.8 V at 500-MHz output sampling rate (0.78-W digital modulator, 0.24-W D/A converter).     

A single-chip multimode receiver for GSM900, DCS1800, PCS1900, and WCDMA

A single-chip, multimode receiver for GSM900, DCS1800, PCS1900, and UTRA/FDD WCDMA is introduced in this paper. The receiver operates at four different radio frequencies with two different baseband bandwidths. The presented chip uses a direct-conversion architecture and consists of a low-noise amplifier (LNA), downconversion mixers with on-chip local-oscillator I/Q generation, channel selection filters, and programmable gain amplifiers. In spite of four receive bands, only four on-chip inductors are used in the single-ended LNA. The repeatable receiver second-order input intercept point (IIP2) of over +42 dBm is achieved with mixer linearization circuitry together with a baseband circuitry having approximately +100-dBV out-of-band IIP2. The noise figure of the SiGe BiCMOS receiver is less than 4.8 dB in all GSM modes, and 3.5 dB in WCDMA. The power consumption from a 2.7-V supply in all GSM modes and in WCDMA mode is 42 and 50 mW, respectively. The silicon area is 9.8 mm/sup 2/ including the bonding pads.     

Suboptimal Exposure to Facial Expressions When Viewing Video Messages From a Small Screen: Effects on Emotion, Attention, and Memory.

The authors examined the effects of suboptimally presented facial expressions on emotional and attentional responses and memory among 39 young adults viewing video (business news) messages from a small screen. Facial electromyography (EMG) and respiratory sinus arrhythmia were used as physiological measures of emotion and attention, respectively. Several congruency priming effects were found. In particular, happy facial primes prompted increased (a) pleasure ratings, (b) orbicularis oculi EMG activity, (c) perceived trustworthiness, and (d) recognition memory for video messages with a positive emotional tone. Emotional and other responses to video messages presented on a small screen can be modified with suboptimal affective primes, but even small differences in the emotional tone of the messages should be allowed for. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Potential of microbial growth control in water hydraulic systems by UV‐irradiation and filtration

Water hydraulic systems use water as a pressure medium and, thus, do not pose such adverse environmental impacts as oil hydraulics. Microbial deterioration of the pressure medium and biofouling of the surfaces restrict the applicability of the water‐based technology. The potential of microbial growth control by UV‐irradiation and filtration was studied in a pilot‐scale water hydraulic system. The UV‐irradiation (25 m Ws cm^?2) of the pressure medium reduced the total viable counts of bacteria by 1–2 log₁₀ cfu cm^?3, whereas the total microbial cell numbers and the numbers of surface‐attached microorganisms remained unaffected. Prefiltration (1.2 µm, absolute) of the pressure medium decreased the total microbial cell number in the water phase and retarded the attachment of bacteria. The filtration during the operation (2 µm, absolute) decreased the total numbers of microbial cells and the total viable counts in the pressure medium, and microbial attachment on the surfaces. Microbial attachment was not prevented by filtration. The microbial water quality obtained by pre‐ and on‐line filtration of the pressure medium was sufficient to ensure the long‐term operation of the water hydraulic system assuming that clean work practices are complied with in assembly and during the operation. © 2002 Society of Chemical Industry