Internal quality and antioxidants content of cold-stored red sweet peppers as affected by polyethylene bag packaging and hot water treatment

Physical (weight, firmness) and compositional (sugars, organic acids, ascorbic acid, phenolic compounds and carotenoids) changes of red sweet peppers (Capsicum annuum L.) were monitored during 21 days of cold storage (at 7.5 °C); fruits were stored without packaging, packaged in low density polyethylene bags, or after hot water dipping (53 °C for 4 min) and packaging. Packaging prevented water loss, and preserved the firmness of the fresh product. Sugars (fructose and glucose) content was practically constant throughout the whole storage time, for all treatments. A moderate accumulation of citric acid was observed during storage, but no marked effects of packaging and hot water dipping on citric and malic acid content. Ascorbic acid content slightly increased in unpackaged and packaged fruits, but not in treated+packaged peppers. Hydroxycinnamics total content seemed not to be affected by cold storage, packaging or hot water treatment, whereas glycosylated flavonoids showed somewhat lowered levels during storage, particularly in the case of unpackaged and packaged+treated fruits. Regarding carotenoids content, the effect of the considered storage conditions seemed to be much smaller than that due to ripening stage. Provitamin A content showed an increasing trend in unpackaged and packaged fruits; packaged+treated peppers were characterised by a lower retention of provitamin A and a higher level of capsanthin and cucurbitaxanthin A with respect to not treated fruits. On the whole, packaging and hot water treatment did not produce noticeable adverse effects on the majority of the examined compositional quality parameters.     

The nonsqueaky wheel

This paper presents a new approach, termed performance-based maintenance, can utilize past and ongoing equipment maintenance records to prioritize electrical distribution equipment with greater detail. The proposed scheme provides cost savings and useful in identifying equipment that can have a lesser level of future maintenance, or extended maintenance cycles. The integration of multiple inputs is required to minimize the risks associated with improper equipment prioritization. The savings can be redirected to areas such as predictive diagnostics, which can provide for greater improvements in reliability while also reducing the over all spend on maintenance.     

The Contribution of Small Vessel Disease to Neurodegeneration: Focus on Alzheimer’s Disease,Parkinson’s Disease and Multiple Sclerosis

Brain small vessel disease (SVD) refers to a variety of structural and functional changes affecting small arteries and micro vessels, and manifesting as white matter changes, microbleeds and lacunar infarcts. Growing evidence indicates that SVD might play a significant role in the neurobiology of central nervous system (CNS) neurodegenerative disorders, namely Alzheimer’s disease (AD) and Parkinson’s disease (PD), and neuroinflammatory diseases, such as multiple sclerosis (MS). These disorders share different pathophysiological pathways and molecular mechanisms (i.e., protein misfolding, derangement of cellular clearance systems, mitochondrial impairment and immune system activation) having neurodegeneration as biological outcome. In these diseases, the actual contribution of SVD to the clinical picture, and its impact on response to pharmacological treatments, is not known yet. Due to the high frequency of SVD in adult-aged patients, it is important to address this issue. In this review, we report preclinical and clinical data on the impact of SVD in AD, PD and MS, with the main aim of clarifying the predictability of SVD on clinical manifestations and treatment response.     

Investigation of the biogenetic reaction sequence of cholesterol in rat tissues,through inhibition with AY-9944

An inhibitor of Δ⁷-reductase, AY-9944 (trans-1,4-bis(2-dichlorobenzylaminomethyl cyclohexane dihydrochloride), was used to investigate the last steps of cholesterol formation in brain and liver of adult and newborn rats. The accumulation of different sterols in the two tissues of the same animals was observed. Δ^5,7-Cholestadien-3β-ol, Δ^7,24-cholestadien-3β-ol and Δ^5,7,24-cholestatrien-3β-ol, which are not present in detectable amounts in control brains, were identified in brains of growing rats treated with AY-9944. An accumulation of Δ^5,7-cholestadien-3β-ol only was found in adult rat tissues. These differences in sterol accumulation are discussed in relation with the possible in vivo pathways of cholesterol biosynthesis.     

Cell-protection mechanism through autophagy in HGFs/<Emphasis Type="Italic">S. mitis</Emphasis> co-culture treated with Chitlac-nAg

Silver-based products have been proven to be effective in retarding and preventing bacterial growth since ancient times. In the field of restorative dentistry, the use of silver ions/nanoparticles has been explored to counteract bacterial infections, as silver can destroy bacterial cell walls by reacting with membrane proteins. However, it is also cytotoxic towards eukaryotic cells, which are capable of internalizing nanoparticles. In this work, we investigated the biological effects of Chitlac-nAg, a colloidal system based on a modified chitosan (Chitlac), administered for 24–48?h to a co-culture of primary human gingival fibroblasts and Streptococcus mitis in the presence of saliva, developed to mimic the microenvironment of the oral cavity. We sought to determine its efficiency to combat oral hygiene-related diseases without affecting eukaryotic cells. Cytotoxicity, reactive oxygen species production, apoptosis induction, nanoparticles uptake, and lysosome and autophagosome metabolism were evaluated. In vitro results show that Chitlac-nAg does not exert cytotoxic effects on human gingival fibroblasts, which seem to survive through a homoeostasis mechanism involving autophagy. That suggests that the novel biomaterial Chitlac-nAg could be a promising tool in the field of dentistry.     

Vacuum retrofits: the process, benefits, and risks

Older circuit breakers have had an excellent reliability for the period of time intended. These circuit breakers have performed satisfactorily for at least 10 to 15 years, and most, 20 to 30 years, with a certain level of preventive maintenance performed. Unfortunately, normal age, deterioration, and wear have brought: many of these circuit breakers to the end of their useful life, from a reliability and maintainability standpoint. We address reliability and maintainability of the existing circuit breakers, as well as the improvements gained by the vacuum retrofit process. Retrofit design factors, which affect reliability and maintainability of the final product, are also addressed; as well as alternatives and cost considerations, applications, specification recommendations, and associated switchgear improvements. The gains achieved in equipment life extension are self evident. A detailed review is also provided concerning the safety interlocks, which must be properly incorporated into a retrofit     

A comparison between classical robust stability conditions

The paper is focused on the comparison between some classical robust stability conditions for continuous‐time linear time‐invariant systems. Such conditions are given as lemmas in the paper, since their statements include some generalizations, needed in order to better compare (and use) them. The analysis is carried out by comparing pairwise the families of systems whose stabilization through a given compensator is guaranteed by each of the considered robust stability conditions. Some properties of the families are formally derived and stated, and some very simple examples arc exhibited in order to illustrate the presented properties and comparisons. A theorem, representing an extension of one of the considered conditions, is proposed in order to overcome some difficulties arising in the use of the classical result. Copyright © 2004 John Wiley & Sons, Ltd.     

Integrated approach between pulsed thermography,near-infrared reflectography and sandwich holography for wooden panel paintings advanced monitoring

The durability of an exterior finish is affected by the characteristics of the wood. Satisfactory finish life is usually more difficult to achieve on woods of higher density. All wood shrinks as it loses moisture and swells as it absorbs moisture, but some species are more stable than others. Species that shrink and swell the most cause more stress on paint films than woods that are more stable [1]. To this end, let us recall that a painting on wood can be considered as a layered structure: The wood support is coated with a number of superposed priming layers made from mixtures of gesso and glue. A frequent fault resulting from such a system is the formation of detached regions inside the layered structure caused by the shrinkage process of the wood support [2]. Obviously, wood deteriorates more rapidly in warm, humid regions with respect to cool or dry places [3]. The influence of wood conditions on surface coatings is a critical point that should be monitored and that depends on environmental parameters such as microclimate. To prevent and control the effects, keeping costs down, a non-destructive monitoring of wood support behavior under thermal stress is needed. In this work, an integrated approach based on traditional and innovative (HI, PT and NIR) techniques was conducted on a primed support of poplar wood with a complex-shape surface containing areas of artificial defects at several depths due to the influence of the support on the various layers. The obtained results could be arranged, if integrated into a multidisciplinary approach, in order to define and design the conservation of the wooden artifacts.     

Physico-chemical characterisation of the inhalable particulate matter (PM10) in an urban area: an analysis of the seasonal trend

Between October 1998 and February 2000, 11 particulate samplings were conducted in an urban area of Rome to evaluate the seasonal trend of PM10 characteristics: seven samplings were made at ground-level and four 30 m above ground level. The samples were analysed by scanning electron microscopy equipped with an EDS X-ray attachment and by transmission electron microscopy and an electron energy-loss spectrometer. The airborne particulate matter was characterised from a physico-chemical point of view to provide information on the particle composition and on the compounds carried on their surface. The data sets, consisting of the atomic concentrations of the constituent chemical elements of the fine (PM3.3) and of the coarse (PM10-3.3) particulate, were subjected to cluster analysis to determine the principal components of PM10. In the particulate matter, the statistical analysis methods allowed us to identify seven groups (clusters) of particles: C-rich particles; carbonates; silica; silicates; sulfates; Fe-rich particles; and metals. Carbonaceous and silicate particles with a surface coating containing S were observed. This sulfur-enriched coating turned out to be a PM3.3 feature strongly dependent upon season.     

Angiotensin-converting enzyme gene polymorphism and reversibility of uremic left ventricular hypertrophy following long-term antihypertensive therapy

BACKGROUND: Prolonged antihypertensive therapy might be less effective in reversing the left ventricular hypertrophy (LVH) in uremics bearing the deleted (DD) allele of the angiotensin converting enzyme (ACE) gene than in patients with the inserted (II) allele or in those heterozygous (ID) for the gene. METHODS: Thirteen DD and 17 II + ID hemodialyzed uremics were followed-up with yearly echocardiography and 24-hour blood pressure (BP) monitoring over five years while on an antihypertensive therapy that included ACE inhibitors as first line drugs. RESULTS: In the II + ID group there were significant decreases of the left ventricular mass index (LVMi) and of both systolic and diastolic BPs. These changes were less pronounced in the DD group, but the difference was not statistically significant given the wide overlap between the two groups. Further analysis of the data revealed that the only factor associated to a decreased LVMi was the decrease of the systolic BP irrespective of the ACE gene genotype of each individual patient. CONCLUSIONS: The ACE-gene genotype does not necessarily predict the extent to which LVMi will be lowered by ACE-inhibitors therapy. The LVH of hypertensive uremics is amenable by long-term antihypertensive therapy provided that it results in significantly decreased systolic blood pressure.