Metal-polyphenol-network coated CaCO3 as pH-responsive nanocarriers to enable effective intratumoral penetration and reversal of multidrug resistance for augmented cancer treatments

Construction of multifunctional stimuli-responsive nanotherapeutics enabling improved intratumoral penetration of therapeutics and reversal of multiple-drug resistance (MDR) is potent to achieve effective cancer treatment. Herein, we report a general method to synthesize pH-dissociable calcium carbonate (CaCO₃) hollow nanoparticles with amorphous CaCO₃ as the template, gallic acid (GA) as the organic ligand, and ferrous ions as the metallic center via a one-pot coordination reaction. The obtained GA–Fe@CaCO₃ exhibits high loading efficiencies to both oxidized cisplatin prodrug and doxorubicin, yielding drug loaded GA–Fe@CaCO₃ nanotherapeutics featured in pH-responsive size shrinkage, drug release, and Fenton catalytic activity. Compared to nonresponsive GA–Fe@silica nanoparticles prepared with silica nanoparticles as the template, such GA–Fe@CaCO₃ confers significantly improved intratumoral penetration capacity. Moreover, both types of drug-loaded GA–Fe@CaCO₃ nanotherapeutics exhibit synergistic therapeutic efficacies to corresponding MDR cancer cells because of the GA–Fe mediated intracellular oxidative stress amplification that could reduce the efflux of engulfed drugs by impairing the mitochondrial-mediated production of adenosine triphosphate (ATP). As a result, it is found that the doxorubicin loaded GA–Fe@CaCO₃ exhibits superior therapeutic effect towards doxorubicin-resistant 4T1 breast tumors via combined chemodynamic and chemo-therapies. This work highlights the preparation of pH-dissociable CaCO₃-based nanotherapeutics to enable effective tumor penetration for enhanced treatment of drug-resistant tumors.

     

Structure, thermal-stability and reducibility of Si-doped Ce–Zr–O solid solution

The Si-doped Ce–Zr–O solid solutions have been prepared by the reverse microemulsion method. The effects of Si and its content on the structure characters, thermal-stability and reducibility of the Ce–Zr–O solid solution have been studied by N₂ adsorption, XRD, laser Raman (LR), TPR, FT-IR, NMR and XPS methods. The results indicate that, there are the bonds of Si–O–M (Ce or Zr) in the Ce–Zr–Si–O solid solutions, and the presence of Si can increase obviously the surface area, thermal-stability, crystal lattice distortion rate, and reducibility of the solid solution. The surface area of the sample with 20 wt.% Si reaches 153 m² g⁻¹ after being calcined at 900 °C for 6 h. The Ce–Zr–O solid solution with 5.2–10 wt.% Si shows excellent thermal-stability and reducibility.     

获得高熔敷速度与低稀释率的等离子粉末堆焊方法

对传统的堆焊方法而言，提高熔敷速度与降低稀释率是矛盾的，能否协调这两方面因素，是实现高效高质堆焊效果的关键，分析了提高熔敷速度，降低稀释率的各种途径，并基于理论的分析与工艺验证，提出采用小压缩孔径，拉长粉末会交点于工件距离是同时获得高熔敷速度，低稀释率堆焊效果的有效途径。     

Floating Catalyst Chemical Vapor Deposition Patterning Nitrogen-Doped Single-Walled Carbon Nanotubes for Shape Tailorable and Flexible Micro-Supercapacitors

Micro-supercapacitors (MSCs) as high-power density energy storage units are designed to meet the booming development of flexible electronics, requiring simple and fast fabrication technology. Herein, a fast and direct solvent-free patterning method is reported to fabricate shape-tailorable and flexible MSCs by floating catalyst chemical vapor deposition (FCCVD). The nitrogen-doped single-walled carbon nanotubes (N-SWCNTs) are directly deposited on a patterned filter by FCCVD with designable patterns and facilely dry-transferred on versatile substrates. The obtained MSCs deliver an excellent areal capacitance of 3.6 mF cm⁻² and volumetric capacitance of 98.6 F cm⁻³ at a scan rate of 5 mV s⁻¹ along with excellent long-term cycle stability over 125 000 circles. Furthermore, the MSCs show good performance uniformity, which can be readily integrated via connection in parallel or series to deliver a stable high voltage (4 V with five serially connected devices) and large capacitance (5.1 mF with five parallel devices) at a scan rate of 100 mV s⁻¹, enabling powering the light emitting displays. Therefore, this method blazes the trail of directly preparing flexible, shape-customizable, and high-performance MSCs.     

基于非均匀检测的机载雷达空时自适应处理方法

提出了一种新的非均匀杂波环境下的数据样本选取方法－－关联维数（ＣＤ）非均匀检测器,研究了非均匀杂波环境中改进干扰协方差矩阵的估计和自适应权的形成问题。仿真结果表明,非均匀检测器与空时自适应处理（ＳＴＡＰ）方法相结合,可显著地改进机载雷达的检测性能。     

基于内容的图象检索技术的研究和发展

多媒体技术和数字图书馆的发展和应用,使基于图象内容的检索技术,成为图象处理和计算机视觉的前沿问题。图象数据库检索查询的研究目的就是实现自动地、智能化地检索和管理图象。文章详细介绍了该技术的研究状况和具体应用,并探讨了其发展前景。     

基于Fluent的汽车空调风道仿真及结构改进

以整车空调风道系统为研究对象,采用网格前处理软件HyperMesh以及CFD流体分析软件Fluent,基于k-εRNG湍流模型,对空调各出风口分风量进行了仿真分析,得出了前排主、副驾以及后排空调出风口的分风量,结果表明,前排主、副驾空调出风口分风量满足设计要求,后排空调出风口分风量小于设计要求的分风量,不能满足设计要求;对分析结果进一步研究,找出影响后排出风口分风量的原因,经过对副仪表骨架风道结构改进,重新划分网格后进行仿真分析,分析结果表明各出风口分风量达到了设计要求.该研究对解决空调风道分风量不均的问题提供了参考.     

基于多代理的敏捷供应链管理研究

从系统的体系结构出发，建立了基于多代理的敏捷供应链管理模型。利用软件agent负责具体的信息和事务处理，通过ECA规则调度多代理的执行。该管理模型为供应链管理系统提供了快速重构和动态扩展的方法。     

Near white light emission from GaN based light emitting diode with GaN/AlGaN distributed Bragg reflector

A near white GaN-based multiple quantum well (MQW) light emitting diode (LED) was grown by metal–organic chemical vapor deposition on top of a 20-period GaN/Al_zGa_1?zN distributed Bragg reflector (DBR). Photoluminescence, electroluminescence and high resolution X-ray diffraction were performed to analyze the sample characteristics. The results show that the introduction of the DBR increases the ratio of the green to blue light intensities. Near white light emission with commission international de l’Eclairage color coordinates x=0.18, y=0.28 was achieved at injection current 20 mA for the sample with DBR.